Indications of Piravix 200 mg
Treatment of novel or re-emerging pandemic influenza virus infections (limited to cases in which other influenza antiviral drugs are ineffective or not sufficiently effective).
Theropeutic Class
Anti-viral drugs
Pharmacology
Piravix 200 mg is a new antiviral drug against influenza. It is metabolized into Piravix 200 mg ribosyl triphosphate (Piravix 200 mg RTP) by an intracellular enzyme, and Piravix 200 mg RTP selectively inhibits RNA polymerase (RNA-dependent RNA polymerase) of the influenza virus, preventing replication of the influenza virus. It is a drug with a mechanism of action different from that of the existing influenza antiviral drugs and effective against all types and sub-types of human influenza A, B, and C viruses in vitro, showing a wide range of anti-viral activity against various influenza virus strains including avian and swine viruses.
Dosage & Administration of Piravix 200 mg
The usual adult dosage is 1600 mg of Piravix 200 mg administered orally twice daily on Day 1, followed by 600 mg orally twice daily from Day 2 to Day 5 or as directed by physicians. The total treatment duration should be 5 days.
Dosage of Piravix 200 mg
The usual adult dosage is 1600 mg of Piravix 200 mg administered orally twice daily on Day 1, followed by 600 mg orally twice daily from Day 2 to Day 5 or as directed by physicians. The total treatment duration should be 5 days.
Interaction of Piravix 200 mg
In animal studies, decreased RBC production,and increases in liver function parameters such as AST, ALP, ALT and total bilirubin, and increased vacuolization in hepatocytes. Toxicity information regarding Piravix 200 mg in humans is not readily available.
Contraindications
Piravix 200 mg is contraindicated for pregnant women and women who may possibly be pregnant.
Side Effects of Piravix 200 mg
Most common side effects are Diarrhea and increase of blood uric acid levels.
Pregnancy & Lactation
Piravix 200 mg may cause delayed development or death of embryos during the early stage of pregnancy. Should not be given during pregnancy.
Precautions & Warnings
Piravix 200 mg should not be given in pregnant women, requirement of the confirmation of non-pregnancy in women of childbearing potential before use, thorough contraception measures from the start of the treatment to 7 days after the end of the treatment. Caution should be taken for Hepatic and renal impaired patient or use Piravix 200 mg as per the direction of registered Physician
Overdose Effects of Piravix 200 mg
In animal studies, decreased RBC production,and increases in liver function parameters such as AST, ALP, ALT and total bilirubin, and increased vacuolization in hepatocytes. Toxicity information regarding Piravix 200 mg in humans is not readily available.
Storage Conditions
Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.
Use In Special Populations
This drug is only approved as an experimental drug and still a lot of studies is needed about it’s efficacy and also toxic reactions and use in children.
Drug Classes
Anti-viral drugs
Mode Of Action
Piravix 200 mg is a new antiviral drug against influenza. It is metabolized into Piravix 200 mg ribosyl triphosphate (Piravix 200 mg RTP) by an intracellular enzyme, and Piravix 200 mg RTP selectively inhibits RNA polymerase (RNA-dependent RNA polymerase) of the influenza virus, preventing replication of the influenza virus. It is a drug with a mechanism of action different from that of the existing influenza antiviral drugs and effective against all types and sub-types of human influenza A, B, and C viruses in vitro, showing a wide range of anti-viral activity against various influenza virus strains including avian and swine viruses.
Pregnancy
Piravix 200 mg may cause delayed development or death of embryos during the early stage of pregnancy. Should not be given during pregnancy.
Pediatric Uses
This drug is only approved as an experimental drug and still a lot of studies is needed about it’s efficacy and also toxic reactions and use in children.