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Naprosyn Plus375 mg+20
Radiant Pharmaceuticals Ltd.
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Solivo375 mg+20 mg
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Medicine overview
Indications of Solivo 375 mg+20 mg
It is indicated for the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis and to decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers.
Theropeutic Class
Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Pharmacology
It is a preparation of Naproxen and Esomeprazole.
Absorption
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+ ATPase in the gastric parietal cell. Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.
Distribution
It inhibits prostaglandin synthesis.
Metabolism
By acting specifically on the proton pump.
Dosage & Administration of Solivo 375 mg+20 mg
The recommended dose is one tablet twice daily. Do not split, chew, crush or dissolve the tablet. This tablet is to be taken at least 30 minutes before meals.
Interaction of Solivo 375 mg+20 mg
ACE Inhibitors, diuretics and beta-blockers: may reduce the antihypertensive effect.Cyclosporin: increases the risk of nephrotoxicity.Lithium: increases plasma level of lithium.Methotrexate: may increase the serum levels of methotrexate.Warfarin: may increase the risk of bleeding complications.Digoxin: may increase the digoxin toxicity.Clopidogrel: may decrease the exposure to the active metabolite of clopidogrel.
Contraindications
It is contraindicated in patients with known hypersensitivity to any components of this products. It is also contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs and for the treatment of per-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Side Effects of Solivo 375 mg+20 mg
The most common side effects are gastritis, erosive gastritis, dyspepsia, diarrhea, gastric ulcer, upper abdominal pain and nausea etc.
Pregnancy & Lactation
The use of this tablet should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
Precautions & Warnings
Caution should be exercised in following conditions:
Fatal cardiovascular thrombotic events like myocardial infarction, stroke, hypertension, congestive heart failure and edema.
Serious GI adverse events.
Hypomagnesaemia.
Renal or hepatic insufficiency.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
Frequently Asked Questions
What is Solivo 375 mg+20 mg used for?
It is indicated for the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis and to decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers.
What is the dosage of Solivo 375 mg+20 mg?
The recommended dose is one tablet twice daily. Do not split, chew, crush or dissolve the tablet. This tablet is to be taken at least 30 minutes before meals.
What are the side effects of Solivo 375 mg+20 mg?
The most common side effects are gastritis, erosive gastritis, dyspepsia, diarrhea, gastric ulcer, upper abdominal pain and nausea etc.
Who should not take Solivo 375 mg+20 mg?
It is contraindicated in patients with known hypersensitivity to any components of this products. It is also contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs and for the treatment of per-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
What precautions should be taken with Solivo 375 mg+20 mg?
Caution should be exercised in following conditions: Fatal cardiovascular thrombotic events like myocardial infarction, stroke, hypertension, congestive heart failure and edema. Serious GI adverse events. Hypomagnesaemia. Renal or hepatic insufficiency.
Is Solivo 375 mg+20 mg safe during pregnancy and breastfeeding?
The use of this tablet should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.