Thyrox50 mcg

As replacement therapy in hypothyroidism of any aetiology. Replacement therapy should not be instituted in transient hypothyroidism during the recovery phase of subacute Thyroiditis. For the suppression of Thyroid Stimulating Hormone (TSH) levels in the presence of goitres, nodules and after radiological and/or surgical treatment of Thyroid cancer. ... Read more As replacement therapy in hypothyroidism of any aetiology. Replacement therapy should not be instituted in transient hypothyroidism during the recovery phase of subacute Thyroiditis. For the suppression of Thyroid Stimulating Hormone (TSH) levels in the presence of goitres, nodules and after radiological and/or surgical treatment of Thyroid cancer. For the suppression of the goitrogenic effects of other drugs such as Lithium. As a diagnostic aid in suppression tests.

Thyroid drugs & hormone

This tablet contains synthetic Levothyroxine (also called Thyroxine or T4) which is identical to the natural hormone T4, produced in the Thyroid gland. About 30% of T4 is converted to the much more active Triiodothyronine (T3) in peripheral tissues. TBG (Thyroxine Binding Globulin) is the major carrier of T4. This binding protects T4 from metabolism and excretion resulting in its long half-life in the circulation. Only about 0.03% of total T4 in plasma is unbound. The half-life of elimination of T4 is 6 to 7 days. In hyperthyroidism, the half-life is shortened to 3 or 4 days, whereas in hypothyroidism it may be 9 to 10 days. In conditions associated with reduced protein in plasma as in nephrosis or hepatic cirrhosis or when binding to protein is inhibited by certain drugs the half-life of T4 may be shortened. The liver is the major site of degradation of Thyroid hormones. T4 is conjugated with Glucuronic and Sulphate conjugates through the Phenolic hydroxyl group and excreted in the urine.There is an enterohepatic circulation of the Thyroid hormones, since they are liberated by hydrolysis in the intestine and reabsorbed. Because of the long half-life of T4, a steady blood level of the biologically more active T3 can be obtained from one single daily dose of Levothyroxine. Therefore, variations in the therapeutic effect are unlikely once the correct dosage has been established.

Adult dose: Initial starting dose: 25-50 meg/day, with gradual increments in dose at 6-8 week intervals, as needed. The Thyrox 50 mcg dose is generally adjusted in 12.5-25 meg increments until the patient with primary hypothyroidism is clinically euthyroid and the serum TSH has normalized. In patients with severe hypothyroidism: Initial dose is 12.5-25 meg/day with increases of 25 meg/day every 2-4 weeks, accompanied by clinical and laboratory assessment,until the TSH level is normalized. In patients with secondary (pituitary) or tertiary (hypothalamic) hypothyroidism: Thyrox 50 mcg dose should be titrated until the patient is clinically euthyroid and the serum free - T4 level is restored to the upper half of the normal range. For patients older than 50 years or for patients under 50 years of age with underlying cardiac disease: 1.7 meg/kg/day. Pediatric Dosage Newborns: The recommended starting dose is 10-15 meg/kg/day. A lower starting dose should be considered in infants at risk for cardiac failure and the dose should be increased in 4-6 weeks as needed based on clinical and laboratory response to treatment. In infants with very low (<5 mcg/dL) or undetectable serum T4 concentrations, the recommended initial starting dose is 50 meg/day of Thyrox 50 mcg. Infants and Children: In children with chronic or severe hypothyroidism, initial dose of 25 meg/day with increments of 25 meg every 2-4 weeks until the desired effect is achieved. Hyperactivity in an older child can be minimized if the starting dose is one-fourth of the recommended full replacement dose and the dose is then increased on a weekly basis by an amount equal to one-fourth the full recommended replacement dose until the full recommended replacement dose is reached. 0-3 months: 10-15 meg/kg/day 3-6 months: 8-10 meg/kg/day 6-12 months: 6-8 meg/kg/day 1-5 years: 5-6 meg/kg/day 6-12 years: 4-5 meg/kg/day >12 years but growth and puberty incomplete: 2-3 meg/kg/day Growth and puberty complete: 1.7 meg/kg/day. The dose should be adjusted based on clinical response and laboratory parameters. In the treatment of goitres, nodules and Thyroid cancer, the objective is to ensure a constant and sufficient suppression of TSH. For suppression of TSH levels, a gradual increase in dosing is usually not necessary. For adults, the usual suppressive dosage of T4 is 2.6 meg/kg of body weight daily. When Thyrox 50 mcg is used as a diagnostic aid, the dosage depends on the type of investigation.

Adult dose: Initial starting dose: 25-50 mcg/day, with gradual increments in dose at 6-8 week intervals, as needed. The Thyrox 50 mcg dose is generally adjusted in 12.5-25 mcg increments until the patient with primary hypothyroidism is clinically euthyroid and the serum TSH has normalized. In patients with severe hypothyroidism: Initial dose is 12.5-25 mcg/day with increases of 25 mcg/day every 2-4 weeks, accompanied by clinical and laboratory assessment,until the TSH level is normalized. In patients with secondary (pituitary) or tertiary (hypothalamic) hypothyroidism: Thyrox 50 mcg dose should be titrated until the patient is clinically euthyroid and the serum free - T4 level is restored to the upper half of the normal range. For patients older than 50 years or for patients under 50 years of age with underlying cardiac disease: 1.7 mcg/kg/day. Pediatric Dosage (Newborns): The recommended starting dose is 10-15 mcg/kg/day. A lower starting dose should be considered in infants at risk for cardiac failure and the dose should be increased in 4-6 weeks as needed based on clinical and laboratory response to treatment. In infants with very low (<5 mcg/dL) or undetectable serum T4 concentrations, the recommended initial starting dose is 50 mcg/day of Thyrox 50 mcg. Pediatric Dosage (Infants and Children): In children with chronic or severe hypothyroidism, initial dose of 25 mcg/day with increments of 25 mcg every 2-4 weeks until the desired effect is achieved. Hyperactivity in an older child can be minimized if the starting dose is one-fourth of the recommended full replacement dose and the dose is then increased on a weekly basis by an amount equal to one-fourth the full recommended replacement dose until the full recommended replacement dose is reached. 0-3 months: 10-15 mcg/kg/day 3-6 months: 8-10 mcg/kg/day 6-12 months: 6-8 mcg/kg/day 1-5 years: 5-6 mcg/kg/day 6-12 years: 4-5 mcg/kg/day >12 years but growth and puberty incomplete: 2-3 mcg/kg/day Growth and puberty complete: 1.7 mcg/kg/day. The dose should be adjusted based on clinical response and laboratory parameters.

Concurrent use of tri/tetracyclic antidepressants and Levothyroxine may increase the therapeutic and toxic effects of both drugs, possibly due to increased receptor sensitivity to catecholamines.Toxic effects may include increased risk of cardiac arrhythmias and CNS stimulation; onset of action of tricyclics may be accelerated. Administration of sertraline in patients stabilized on Levothyroxine may result in increased Levothyroxine requirements. Addition of Levothyroxine to antidiabetic or insulin therapy may result in increased antidiabetic agent or insulin requirements. Careful monitoring of diabetic control is recommended, especially when thyroid therapy is started, changed, or discontinued. Serum digitalis glycoside levels may be reduced in hyperthyroidism or when the hypothyroid patient is converted to the euthyroid state. Therapeutic effect of digitalis glycosides may be reduced.

Untreated subclinical or overt Thyrotoxicosis of any etiology Acute Myocardial Infarction Uncorrected Adrenal failure.

Adverse reactions associated with Levothyroxine therapy are primarily those of hyperthyroidism due to therapeutic overdose. They include the following: General: Fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating; Central nervous system: Headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia. Musculoskeletal: Tremors, muscle weakness. Cardiovascular: Palpitations, tachycardia, arrhythmias, increased pulse and blood pressure Respiratory: Dyspnea. Gastrointestinal: Diarrhea, vomiting, abdominal cramps. Dermatologic: Hair loss, flushing.

Pregnancy Category A. Pregnancy may increase Levothyroxine requirements. Although Thyroid hormones are excreted only minimally in human milk,caution should be exercised when it is administered to a nursing woman.However, adequate replacement doses of Levothyroxine are generally needed to maintain normal lactation.

In patients whose hypothyroidism is due to a decrease in pituitary gland function, there may also be adrenocortical insufficiency;before starting Levothyroxine therapy, this should be treated by adequate replacement with Corticosteroids to prevent acute adrenal insufficiency. The choice of the starting dose and of any increases in dosing should be made with great care in patients with cardiovascular disease and/or severe and long-existing hypothyroidism.Too high an initial dose or too rapid an increase in dosing may lead to development or worsening of angina complaints, arrhythmias, myocardial infarction, cardiac failure or to sudden increase in blood pressure, especially in older patients. Any marked change of body weight during treatment with T4 requires adjustment of the dosage. When monitoring blood levels of T3 and T4, it should be borne in mind that a "high" normal to slightly increased T4 level will be necessary in order to obtain a normal level of T3. The correct dosage of Levothyroxine in primary hypothyroidism should generally be established by monitoring the serum level of TSH to see whether it has normalized. Because intoxication with Thyroid preparations may have serious consequences.

The signs and symptoms of overdose are those of hyperthyroidism - agitation, confusion, irritability, hyperactivity, headache, sweating, mydriasis, tachycardia, arrhythmias, tachypnoea, pyrexia, increased bowel movements and convulsions. Cerebral embolism, shock, coma, and death have been reported. Symptoms may not necessarily be evident or may not appear until several days after ingestion of Thyrox 50 mcg. Dose of Thyrox 50 mcg should be reduced or temporarily discontinued if signs or symptoms of overdosage occur. Treatment is symptomatic.

Store below 30°C and dry place, protect from light. Keep out of the reach of children.

Thyroid drugs & hormone

This tablet contains synthetic Levothyroxine (also called Thyroxine or T4) which is identical to the natural hormone T4, produced in the Thyroid gland. About 30% of T4 is converted to the much more active Triiodothyronine (T3) in peripheral tissues. TBG (Thyroxine Binding Globulin) is the major carrier of T4. This binding protects T4 from metabolism and excretion resulting in its long half-life in the circulation. Only about 0.03% of total T4 in plasma is unbound. The half-life of elimination of T4 is 6 to 7 days. In hyperthyroidism, the half-life is shortened to 3 or 4 days, whereas in hypothyroidism it may be 9 to 10 days. In conditions associated with reduced protein in plasma as in nephrosis or hepatic cirrhosis or when binding to protein is inhibited by certain drugs the half-life of T4 may be shortened. The liver is the major site of degradation of Thyroid hormones. T4 is conjugated with Glucuronic and Sulphate conjugates through the Phenolic hydroxyl group and excreted in the urine.There is an enterohepatic circulation of the Thyroid hormones, since they are liberated by hydrolysis in the intestine and reabsorbed. Because of the long half-life of T4, a steady blood level of the biologically more active T3 can be obtained from one single daily dose of Levothyroxine. Therefore, variations in the therapeutic effect are unlikely once the correct dosage has been established.

Pregnancy Category A. Pregnancy may increase Levothyroxine requirements. Although Thyroid hormones are excreted only minimally in human milk,caution should be exercised when it is administered to a nursing woman.However, adequate replacement doses of Levothyroxine are generally needed to maintain normal lactation.

Q: What is Thyrox 50mcg used for?
Thyrox 50mcg effectively treats hypothyroidism, a condition where the thyroid gland fails to produce enough thyroid hormone. Thyroid hormone is essential for many bodily functions, including metabolism, growth, and development.

Q: How does Thyrox 50mcg work?
Thyrox 50mcg is a synthetic form of thyroid hormone. It replaces the thyroid hormone that the body is failing to produce on its own.

Q: What is the dosage of Thyrox 50mcg?
The dosage of Thyrox 50mcg will vary depending on the individual's needs. It is important to start with a low dose and increase it gradually until the desired effect is achieved.

Q: How long does it take for Thyrox 50mcg to work?
It may take several weeks or even months to see the full effects of Thyrox 50mcg. However, most people will start to feel better within a few days or weeks of starting treatment.

Q: What are the side effects of Thyrox 50mcg?
The common side effects of Thyrox 50mcg are mild and go away on their own - Headache, Insomnia, Diarrhea, Tremors, Increased appetite, Sweating, and Weight loss. These serious issues are rare - Allergic reactions ,Heart problems, Liver problems, and Bone problems. 

Q: What are the drug interactions of Thyrox 50mcg?
Thyrox 50mcg can interact with a number of other medications. It is important to tell your doctor about all of the medications you are taking before starting Thyrox 50mcg.