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Tamsulosin Hydrochloride + Dutasteride: Brands, Price & Uses in Bangladesh
Tamsulosin Hydrochloride + Dutasteride is a fixed-dose combination of an alpha-1 adrenergic receptor antagonist (tamsulosin) and a 5-alpha reductase inhibitor (dutasteride).
About Tamsulosin Hydrochloride + Dutasteride
Indications of Tamsulosin Hydrochloride + Dutasteride
Tamsulosin Hydrochloride + Dutasteride is a fixed-dose combination of an alpha-1 adrenergic receptor antagonist (tamsulosin) and a 5-alpha reductase inhibitor (dutasteride).
Established/FDA-approved use
- Treatment of the signs and symptoms of symptomatic benign prostatic hyperplasia (BPH) in adult men with an enlarged prostate.
- Used to relieve lower urinary tract symptoms of BPH (weak urinary stream, urinary frequency, urgency, nocturia, incomplete bladder emptying) and to reduce the long-term risk of acute urinary retention and the need for BPH-related surgery.
Important limitation
Tamsulosin Hydrochloride + Dutasteride is not approved or indicated for the prevention of prostate cancer, and it is not indicated for use in women or children.
Dosage & Administration of Tamsulosin Hydrochloride + Dutasteride
Adult dose (BPH)
| Population | Dose | Frequency |
|---|---|---|
| Adult men with symptomatic BPH | One capsule (dutasteride 0.5 mg / tamsulosin HCl 0.4 mg) | Once daily, approximately 30 minutes after the same meal each day |
Administration instructions
- Swallow the capsule whole; do not chew, crush, or open the capsule, as contact with the capsule contents may irritate the oropharyngeal mucosa.
- Take at approximately the same time each day, after the same meal, for consistent absorption.
- Not indicated for use in women or children under any circumstances.
Renal impairment
No dose adjustment is required in patients with renal impairment; Tamsulosin Hydrochloride + Dutasteride has not been studied in patients with end-stage renal disease.
Hepatic impairment
No dose adjustment is established for mild-to-moderate hepatic impairment; use in patients with severe hepatic impairment has not been studied and is not recommended (see Contraindications).
Side Effects of Tamsulosin Hydrochloride + Dutasteride
The most common adverse effects reported with Tamsulosin Hydrochloride + Dutasteride relate to its sexual, hemodynamic, and endocrine effects:
- Ejaculatory dysfunction (including retrograde ejaculation, decreased ejaculate volume) — the most frequently reported effect, more common with combination therapy than with either component alone.
- Erectile dysfunction / impotence
- Decreased libido
- Dizziness and, less commonly, orthostatic hypotension (related to the tamsulosin component)
- Breast disorders, including gynecomastia and breast tenderness (related to the dutasteride component; less common)
- Less common: rhinitis, headache, and postmarketing reports of hypersensitivity reactions (rash, urticaria, angioedema), priapism, and, rarely, severe skin reactions.
Contraindications of Tamsulosin Hydrochloride + Dutasteride
Tamsulosin Hydrochloride + Dutasteride is contraindicated in:
- Patients with known hypersensitivity to tamsulosin, dutasteride, other 5-alpha reductase inhibitors, or any component of Tamsulosin Hydrochloride + Dutasteride (including serious skin reactions, angioedema, urticaria, or respiratory symptoms).
- Women, particularly women who are pregnant or who may become pregnant, due to the teratogenic risk of dutasteride to a male fetus (see Pregnancy and Lactation).
- Children — Tamsulosin Hydrochloride + Dutasteride is not indicated for use in pediatric patients.
- Patients with severe hepatic impairment.
Frequently Asked Questions about Tamsulosin Hydrochloride + Dutasteride
What is Tamsulosin Hydrochloride + Dutasteride used for?
Tamsulosin Hydrochloride + Dutasteride is used to treat the symptoms of benign prostatic hyperplasia (BPH), an enlarged prostate, in adult men — including weak urine stream, frequent or urgent urination, and nighttime urination — and to reduce the long-term risk of acute urinary retention and the need for BPH-related surgery.
How should I take Tamsulosin Hydrochloride + Dutasteride?
Take one capsule of Tamsulosin Hydrochloride + Dutasteride by mouth once daily, about 30 minutes after the same meal each day. Swallow the capsule whole — do not chew, crush, or open it, as the contents can irritate the mouth and throat.
Can women take Tamsulosin Hydrochloride + Dutasteride?
No. Tamsulosin Hydrochloride + Dutasteride is not indicated for use in women and is contraindicated in pregnancy, because the dutasteride component can cause abnormalities in the genitals of a male fetus. Women who are pregnant or may become pregnant should not handle Tamsulosin Hydrochloride + Dutasteride capsules, particularly if they are leaking.
Will Tamsulosin Hydrochloride + Dutasteride affect my PSA test?
Yes. Tamsulosin Hydrochloride + Dutasteride lowers PSA levels by about half after several months of use. Tell your doctor that you are taking Tamsulosin Hydrochloride + Dutasteride before any PSA test, so the result can be interpreted correctly, and continue routine prostate cancer screening as advised.
What are the common side effects of Tamsulosin Hydrochloride + Dutasteride?
The most common side effects are related to sexual function, including retrograde or reduced ejaculation, erectile dysfunction, and decreased libido, as well as dizziness and, less commonly, breast tenderness or enlargement.
Do I need to tell my eye surgeon that I am taking Tamsulosin Hydrochloride + Dutasteride?
Yes. If you are having cataract or other eye surgery, tell your ophthalmologist that you take or have taken Tamsulosin Hydrochloride + Dutasteride, because it can cause a condition called intraoperative floppy iris syndrome (IFIS) that affects surgical planning.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.