Aceclofenac: Brands, Price & Uses in Bangladesh

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation associated with the following established indications:

• Osteoarthritis — for relief of joint pain and stiffness.
• Rheumatoid arthritis — for relief of joint pain, swelling, and inflammation.
• Ankylosing spondylitis — for relief of spinal and joint pain and inflammation.
• Acute musculoskeletal pain, including low back pain (lumbago), periarthritis, sprains, and post-traumatic pain and swelling.
• Postoperative and dental pain (e.g. toothache), as short-term symptomatic relief.

Aceclofenac provides symptomatic relief of pain and inflammation; it does not alter the underlying course of the disease. It should be used at the lowest effective dose for the shortest duration consistent with the patient's treatment goals.

Adult Dose

Pediatric Dose

Safety and efficacy of Aceclofenac have not been established in children (typically under 18 years, with some labeling specifying under 6 years); Aceclofenac is generally not recommended for pediatric use. See Use in Special Populations.

Renal/Hepatic Impairment

Aceclofenac should be used with caution and at the lowest effective dose in patients with mild renal or hepatic impairment; it should be avoided in patients with severe renal or hepatic impairment (see Precautions and Warnings).

Administration

Aceclofenac tablets should be swallowed whole with water, preferably with or after food to reduce gastrointestinal irritation. Sustained/extended-release tablets must not be crushed or chewed.

Most side effects of Aceclofenac are mild and reversible on discontinuation. Commonly reported effects include:

• Gastrointestinal: Dyspepsia, abdominal pain, nausea, diarrhea; less commonly, peptic ulcer, gastrointestinal bleeding, or perforation (class effect of NSAIDs; see Precautions).
• Nervous system: Headache, dizziness, vertigo, drowsiness.
• Skin: Rash, pruritus, urticaria.
• Other (less common): Elevated liver enzymes, edema, elevated blood pressure, and, rarely, renal impairment.

Serious but rare reactions include severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), severe hepatotoxicity, and cardiovascular thrombotic events (myocardial infarction, stroke) as seen with NSAIDs as a class. Patients should seek prompt medical attention for signs of GI bleeding (black stools, vomiting blood), unexplained rash, jaundice, or chest pain/shortness of breath.