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Adenosine: Brands, Price & Uses in Bangladesh
Paroxysmal Supraventricular Tachycardia (PSVT) Adenosine is established (FDA-approved) for the rapid conversion of paroxysmal supraventricular tachycardia (PSVT) to normal sinus rhythm and more.
About Adenosine
Indications of Adenosine
Paroxysmal Supraventricular Tachycardia (PSVT)
Adenosine is established (FDA-approved) for the rapid conversion of paroxysmal supraventricular tachycardia (PSVT) to normal sinus rhythm, including PSVT associated with accessory bypass tracts (e.g., Wolff-Parkinson-White syndrome).
Diagnostic Aid in Undifferentiated Tachycardia
Adenosine is established as a diagnostic aid when the mechanism of a wide- or narrow-complex tachycardia is uncertain; by producing transient AV block, it can unmask an underlying atrial flutter or atrial fibrillation that was previously obscured by a fast ventricular rate.
Pharmacologic Cardiac Stress Testing
A higher-dose, continuous-infusion formulation of Adenosine is established as a coronary vasodilator stress agent for myocardial perfusion imaging in patients who cannot exercise adequately for a standard exercise stress test.
Not Indicated For
Adenosine is not indicated for ongoing/maintenance antiarrhythmic therapy, and it does not convert atrial fibrillation, atrial flutter, or ventricular tachycardia to sinus rhythm, although it may transiently slow the ventricular rate enough to aid diagnosis of these rhythms.
Dosage & Administration of Adenosine
Dosing of Adenosine depends on whether it is being used to terminate an episode of paroxysmalsupraventricular tachycardia (PSVT), to aid arrhythmia diagnosis, or as a coronary vasodilator for pharmacologic cardiac stress testing.Adenosine is given only by rapid intravenous bolus or continuous IV infusion, administered by a trained healthcare professional in a settingwith continuous ECG monitoring and resuscitation equipment immediately available; it is never self-administered or taken by mouth.
Side Effects of Adenosine
Common Effects (Transient, Usually Seconds to About a Minute)
- Flushing
- Chest pain, pressure, or discomfort
- Shortness of breath (dyspnea)
- Lightheadedness or headache
- Nausea
- A sense of impending doom
- Tingling in the arms
- Brief new rhythm disturbances (extra beats, sinus bradycardia, or transient high-degree AV block) as an expected pharmacologic effect
Serious Effects (Seek Immediate Medical Attention)
- Severe or prolonged wheezing/bronchospasm, especially in patients with asthma (see Precautions and Warnings)
- Prolonged high-degree AV block or asystole that does not resolve spontaneously
- Severe or persistent low blood pressure
- Chest pain suggestive of myocardial ischemia
- A new, sustained ventricular arrhythmia
- Signs of a severe allergic reaction
Contraindications of Adenosine
- Second- or third-degree AV block, or sick sinus syndrome, in patients without a functioning artificial pacemaker.
- Symptomatic bradycardia, in patients without a functioning artificial pacemaker.
- Known hypersensitivity to Adenosine.
- For use specifically as a pharmacologic cardiac stress agent: known or suspected bronchoconstrictive or bronchospastic lung disease (e.g., asthma), because Adenosine can precipitate severe bronchospasm.
Frequently Asked Questions about Adenosine
What is Adenosine used for?
Adenosine is used in a hospital or emergency setting to rapidly stop an episode of paroxysmal supraventricular tachycardia (PSVT), to help diagnose the cause of certain fast heart rhythms, and, at a different dose and given as an infusion, as a stress agent for cardiac perfusion imaging in people who cannot exercise for a standard stress test.
How is Adenosine given, and why does it have to be so fast?
Adenosine is given as a very rapid intravenous push into a large vein, immediately followed by a fast saline flush. This speed is necessary because Adenosine is broken down by the body within seconds, so a slow injection would be broken down before it reached the heart and would not work.
Why do I feel flushing, chest pressure, or a strange sense of doom after receiving Adenosine?
These are expected, transient effects of Adenosine caused by its brief action on the heart and blood vessels. They typically last only a few seconds to about a minute and resolve on their own as the drug is broken down; your care team will monitor you closely throughout.
Is Adenosine safe during pregnancy?
Adenosine should be used in pregnancy only if a doctor determines it is clearly needed and the benefit outweighs the potential risk, and only in a monitored hospital setting. It has been used for maternal PSVT when other measures fail, but this decision is always made case by case by the treating physician. See Pregnancy and Lactation for details.
Can Adenosine be taken as a tablet at home?
No. Adenosine is only given as an intravenous injection or infusion by trained healthcare professionals in a monitored clinical setting with resuscitation equipment available; it is not available as a home or self-administered medicine.
What happens if too much Adenosine is given?
Because Adenosine's effects last only seconds, most excess effects (such as marked flushing, low blood pressure, or a slow heart rate) resolve quickly once the dose or infusion is stopped, and care is mainly supportive with close monitoring. In severe cases, a specific antagonist medicine can be given. See Overdose Effects for details.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.