5% Off
Actilyse50 mg/vial
Radiant Pharmaceuticals Ltd.
৳45600.00
Add to cart
Generic medicine
Alteplase: Brands, Price & Uses in Bangladesh
Alteplase is a recombinant tissue plasminogen activator (tPA) indicated for the emergency treatment of specific thromboembolic conditions.
About Alteplase
Indications of Alteplase
Alteplase is a recombinant tissue plasminogen activator (tPA) indicated for the emergency treatment of specific thromboembolic conditions. It must only be administered in a hospital setting by clinicians experienced in thrombolytic therapy.
FDA-Approved Indications
- Acute Ischemic Stroke (AIS): For the management of acute ischemic stroke in adults, administered within a strict time window from onset of stroke symptoms (within 3 hours per original approval; guideline bodies such as the American Heart Association/American Stroke Association support use up to 4.5 hours in appropriately selected patients). Imaging-confirmed absence of hemorrhage and exclusion of contraindications is mandatory before Alteplase is given.
- Acute Myocardial Infarction (AMI): For the lysis of thrombi obstructing coronary arteries in adults with acute MI, to reduce infarct size and reduce the incidence of heart failure and mortality.
- Acute Massive Pulmonary Embolism (PE): For the management of acute massive PE in adults, particularly when hemodynamically unstable.
- Restoration of Central Venous Access Device (CVAD) Function: For adult and pediatric patients with a CVAD (e.g., a central line) that is not functioning properly due to occlusion by a clot.
Guideline-Supported / Adjunct Use
- Extended time-window use (3-4.5 hours) of Alteplase in acute ischemic stroke is supported by AHA/ASA stroke guidelines in carefully selected patients, though this falls outside the original, narrower FDA-approved window.
Alteplase is a time-critical, specialist-administered emergency medicine and is not intended for outpatient, elective, or self-administered use.
Dosage & Administration of Alteplase
Alteplase is administered only in a hospital/emergency setting under close monitoring, with dosing individualized by indication and patient weight. The maximum total dose must never be exceeded regardless of patient weight. See Dosage for exact per-indication amounts and Administration for infusion technique.
| Indication | Typical Regimen |
|---|---|
| Acute Ischemic Stroke | 0.9 mg/kg IV (max 90 mg total); 10% as bolus, remainder infused over 60 minutes |
| Acute Myocardial Infarction | Weight-based accelerated infusion over 90 minutes, or 3-hour infusion regimen, max 100 mg total |
| Acute Massive Pulmonary Embolism | 100 mg IV infused over 2 hours |
| Occluded Central Venous Access Device | 2 mg/2 mL instilled into the catheter lumen (weight-based in children) |
Side Effects of Alteplase
The most common and most serious adverse reaction associated with Alteplase is bleeding.
Common
- Superficial or internal bleeding (e.g., at puncture/access sites, gastrointestinal, genitourinary)
- Bruising (ecchymosis)
- Hypotension
- Nausea and vomiting
Serious (require immediate medical attention)
- Intracranial hemorrhage (the most serious complication, especially in stroke treatment)
- Orolingual angioedema (more frequent with concurrent ACE inhibitor use)
- Reperfusion arrhythmias (during treatment of myocardial infarction)
- Cholesterol embolization (rare)
- Anaphylactoid/hypersensitivity reactions (rare)
Contraindications of Alteplase
Alteplase is contraindicated in patients with any of the following, because of an unacceptably high risk of serious or fatal bleeding:
- Known hypersensitivity to Alteplase or any component of the formulation.
- Active internal bleeding.
- History of intracranial hemorrhage.
- Known intracranial neoplasm, arteriovenous malformation, or aneurysm.
- Suspected or confirmed subarachnoid hemorrhage.
- Recent (within 3 months) intracranial or intraspinal surgery, or serious head trauma.
- Known bleeding diathesis.
- Severe, uncontrolled hypertension at the time of treatment.
- For the stroke indication specifically: current use of oral anticoagulants with an elevated INR (>1.7) or prolonged PT, or use of direct thrombin/factor Xa inhibitors with evidence of anticoagulant effect; and suspected aortic dissection.
Additional indication-specific exclusion criteria (e.g., precise stroke-onset time windows, recent major surgery, active peptic ulcer disease) apply per detailed clinical protocols and must be reviewed by the treating physician before Alteplase is used; these function as careful patient-selection criteria rather than universal absolute contraindications. See Precautions and Warnings.
Frequently Asked Questions about Alteplase
What is Alteplase used for?
Alteplase is an emergency thrombolytic ("clot-busting") medicine used in hospital settings to treat acute ischemic stroke, acute heart attack (myocardial infarction), acute massive pulmonary embolism, and to restore function to blocked central venous catheters.
Is Alteplase safe during pregnancy?
Alteplase has not been well studied in pregnancy. Because it is used only in life-threatening emergencies, a physician may still recommend it if the potential benefit to the mother is judged to outweigh the potential risk to the fetus. This decision should always be made by the treating physician on a case-by-case basis, never by the patient alone.
What is the most serious risk of Alteplase treatment?
The most serious risk of Alteplase is bleeding, including life-threatening bleeding inside the brain (intracranial hemorrhage). This is why Alteplase is only given in a hospital by specially experienced clinicians after careful screening.
Can Alteplase be taken at home or as a tablet?
No. Alteplase is not an outpatient or self-administered medicine. It is given only as an intravenous injection/infusion in a hospital emergency setting under continuous monitoring.
What happens if too much Alteplase is given (overdose)?
An overdose of Alteplase mainly causes bleeding, which can be serious. Because Alteplase is only given by healthcare professionals in a hospital, any signs of overdose or excessive bleeding are managed immediately by the treating medical team; the infusion is stopped and supportive treatment, including blood products, is given as needed. Patients or family members should alert hospital staff or seek emergency medical attention right away if unusual bleeding is noticed.
Are there medicines that interact with Alteplase?
Yes. Blood thinners (anticoagulants), antiplatelet medicines such as aspirin, and ACE inhibitor blood pressure medicines can increase the risk of bleeding or swelling reactions when used around the time of Alteplase treatment. Patients should tell the medical team about all medicines they take before Alteplase is given, if there is time to do so in the emergency setting.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.