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Amlodipine Besilate + Olmesartan Medoxomil: Brands, Price & Uses in Bangladesh
Amlodipine Besilate + Olmesartan Medoxomil is a fixed-dose combination indicated for the treatment of hypertension (high blood pressure).
About Amlodipine Besilate + Olmesartan Medoxomil
Indications of Amlodipine Besilate + Olmesartan Medoxomil
Amlodipine Besilate + Olmesartan Medoxomil is a fixed-dose combination indicated for the treatment of hypertension (high blood pressure). Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
- Add-on/substitution therapy: For patients whose blood pressure is not adequately controlled on monotherapy with either a calcium channel blocker (such as amlodipine) or an angiotensin II receptor blocker (such as olmesartan) alone.
- Initial therapy: May be used as initial treatment in patients who are likely to need multiple antihypertensive drugs to achieve their blood pressure goals, based on individualized risk assessment by a physician.
Amlodipine Besilate + Olmesartan Medoxomil is not indicated for initial therapy in patients whose blood pressure can likely be controlled with a single agent, and it is not approved for use in children.
Dosage & Administration of Amlodipine Besilate + Olmesartan Medoxomil
Dosing of Amlodipine Besilate + Olmesartan Medoxomil is individualized based on prior antihypertensive therapy and blood pressure response, and should be adjusted only under a physician's supervision.
| Clinical Situation | Typical Dosing Guidance |
|---|---|
| Not controlled on amlodipine monotherapy | Add olmesartan medoxomil component; combination typically started at 5 mg/20 mg once daily |
| Not controlled on olmesartan monotherapy | Add amlodipine component; combination typically started at 5 mg/20 mg once daily |
| Initial combination therapy (physician-selected) | Usual starting dose 5 mg/20 mg once daily; some patients may start at 10 mg/20 mg or 5 mg/40 mg |
| Dose titration | If blood pressure remains uncontrolled after 2-4 weeks, dose may be titrated up to a maximum of 10 mg/40 mg once daily |
See Use in Special Populations for renal and hepatic dosing considerations.
Side Effects of Amlodipine Besilate + Olmesartan Medoxomil
Common side effects of Amlodipine Besilate + Olmesartan Medoxomil include:
- Peripheral edema (swelling of the ankles/feet, dose-related, from the amlodipine component)
- Dizziness and headache
- Symptomatic hypotension, particularly after the first dose or a dose increase
- Flushing and palpitations
- Fatigue
- Hyperkalemia (elevated blood potassium)
- Upper respiratory infection symptoms
Important rare but serious effect: Olmesartan has been associated with a rare condition called sprue-like enteropathy - severe, chronic diarrhea with substantial weight loss, sometimes occurring months to years after starting treatment and often diagnosed only after other causes (such as celiac disease) have been ruled out. Symptoms generally resolve after discontinuing Amlodipine Besilate + Olmesartan Medoxomil. Patients who develop unexplained chronic diarrhea and weight loss while on this medicine should seek prompt medical evaluation.
Contraindications of Amlodipine Besilate + Olmesartan Medoxomil
Amlodipine Besilate + Olmesartan Medoxomil is contraindicated in:
- Patients with known hypersensitivity to amlodipine, olmesartan medoxomil, other dihydropyridine calcium channel blockers, or any component of the formulation.
- Pregnancy - the olmesartan component can cause injury and death to the developing fetus when used during the second and third trimesters (see Pregnancy and Lactation); discontinue as soon as pregnancy is detected.
- Concomitant use with aliskiren in patients with diabetes mellitus.
Frequently Asked Questions about Amlodipine Besilate + Olmesartan Medoxomil
What is Amlodipine Besilate + Olmesartan Medoxomil used for?
Amlodipine Besilate + Olmesartan Medoxomil is used to treat high blood pressure (hypertension), especially in patients who need more than one medicine to control their blood pressure.
Can I take Amlodipine Besilate + Olmesartan Medoxomil during pregnancy?
No. Amlodipine Besilate + Olmesartan Medoxomil is contraindicated in pregnancy because it can cause serious injury or death to the developing baby, especially if used during the second or third trimester. If you become pregnant while taking this medicine, stop taking it and contact your physician immediately.
What is the most serious rare side effect I should know about?
A rare but serious condition called sprue-like enteropathy has been reported with the olmesartan component of Amlodipine Besilate + Olmesartan Medoxomil. It causes severe, chronic diarrhea with significant weight loss that can develop months or even years after starting treatment. If you experience unexplained ongoing diarrhea and weight loss, contact your physician promptly, as this medicine may need to be stopped.
How should I take this medicine?
Amlodipine Besilate + Olmesartan Medoxomil should be taken once daily, with or without food, at the same time each day. Swallow the tablet whole with water. Do not stop taking it suddenly without consulting your physician.
What should I avoid while taking this medicine?
Avoid potassium supplements or salt substitutes containing potassium unless directed by your physician, as Amlodipine Besilate + Olmesartan Medoxomil can raise blood potassium levels. Also inform your physician about all other medicines you take, including NSAIDs, lithium, and other blood pressure medicines, due to possible interactions.
What should I do if I miss a dose or take too much?
If you miss a dose of Amlodipine Besilate + Olmesartan Medoxomil, take it as soon as you remember unless it is almost time for the next dose. If you suspect an overdose (symptoms may include severe dizziness, fainting, or very low blood pressure), seek emergency medical attention immediately.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.