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Rezor Max

Rezor Max5 mg + 20mg

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Medicine overview

Indications of Rezor Max 5 mg + 20mg

Indicated for the treatment of hypertension alone or with other antihypertensive agentsthe target goal

Dosage of Rezor Max 5 mg + 20mg

Notes:Substitute individually titrated components for patients on Amlodipine and Olmesartan Medoxomil. This combination may also be given with increased amounts of Amlodipine, Olmesartan Medoxomil, or both, as needed
Initial therapy
Dosage:Initiate with 5/20 mg once daily for 1 to 2 weeks and titrate as needed up to a maximum of 10/40 mg once daily
Notes:Due to decreased clearance of Amlodipine among elderly patients the recommended starting dose of Amlodipine is 2.5 mg in patients 75 years. The lowest dose of the combination is 5/20 mg; therefore, initial therapy with this combination drug is not recommended in patients >75 years old

Interaction of Rezor Max 5 mg + 20mg

The antihypertensive effect of angiotensin II receptor antagonists, including Olmesartan Medoxomil may be attenuated by NSAIDs including selective COX-2 inhibitors. Blood pressure, renal function and electrolytes should be closely monitored in patients on combination therapy and other agents that affect the RAS.

Contraindications

Cannot be co-administered with Aliskiren in patients with diabetes.

Side Effects of Rezor Max 5 mg + 20mg

The most common side effects include peripheral edema, headache, flushing, and dizziness. It can also cause Intestinal problems known a sprue-like enteropathy.

Precautions & Warnings

Amlodipine and Olmesartan Medoxomil combination should be used with caution because there is a risk for- Hypotension in volume- or salt depleted patients. Vasodilation in patients with severe aortic stenosis. Increased frequency, duration or severity of angina or acute Ml in patients with severe obstructive coronary artery disease.

Overdose Effects of Rezor Max 5 mg + 20mg

There is no information on over dosage in humans.

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children.

Drug Classes

Combined antihypertensive preparations

Mode Of Action

Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.

Absorption

Amlodipine has a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.

Distribution

Olmesartan Medoxomil blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues, (e.

Metabolism

Olmesartan Medoxomil does not inhibit ACE (kinase II, the enzyme that converts angiotensin I to angiotensin II and degrades bradykinin).

Excretion

It also stimulates aldosterone secretion by the adrenal cortex. vascular smooth muscle, adrenal gland).

Pregnancy

Pregnancy Category D. Amlodipine and Olmesartan Medoxomil combination should not be used in 2nd and 3rd trimester because it can cause fetal death. When pregnancy is detected this combination should be discontinued as soon as possible. It is not known whether Olmesartan and Amlodipine are excreted in human milk. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Uses

Pediatric use: The safety and effectiveness have not been established in pediatric patients.Geriatric use: No overall differences in safety or effectiveness were observed between subjects 65 years of age or older and younger subjects.Renal impairment: There are no studies in patients with renal impairment.Hepatic impairment: Initial therapy is not recommended in hepatically impaired patients.

Frequently Asked Questions

What is Rezor Max 5 mg + 20mg used for?

Indicated for the treatment of hypertension alone or with other antihypertensive agents, to lower blood pressure. This combination drug is indicated as initial therapy in patients likely to need multiple antihypertensive agents to achieve their blood pressure goals. The decision to use a combination ... Read moreIndicated for the treatment of hypertension alone or with other antihypertensive agent…

What is the dosage of Rezor Max 5 mg + 20mg?

Substitute individually titrated components for patients on Amlodipine and Olmesartan Medoxomil. This combination may also be given with increased amounts of Amlodipine, Olmesartan Medoxomil, or both, as needed.Initial therapy: Initiate with 5/20 mg once daily for 1 to 2 weeks and titrate as needed up to a maximum of 10/40 mg once daily. Due to decreased clearance of Amlodipine among elderly patie…

What are the side effects of Rezor Max 5 mg + 20mg?

The most common side effects include peripheral edema, headache, flushing, and dizziness. It can also cause Intestinal problems known a sprue-like enteropathy.

Who should not take Rezor Max 5 mg + 20mg?

Cannot be co-administered with Aliskiren in patients with diabetes.

What precautions should be taken with Rezor Max 5 mg + 20mg?

Amlodipine and Olmesartan Medoxomil combination should be used with caution because there is a risk for- Hypotension in volume- or salt depleted patients. Vasodilation in patients with severe aortic stenosis. Increased frequency, duration or severity of angina or acute Ml in patients with severe obstructive coronary artery disease.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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