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Amlodipine + Telmisartan: Brands, Price & Uses in Bangladesh
Approved Indications Amlodipine + Telmisartan is a fixed-dose combination of a calcium channel blocker (amlodipine) and an angiotensin II receptor blocker (telmisartan) that is indicated for the…
About Amlodipine + Telmisartan
Indications of Amlodipine + Telmisartan
Approved Indications
Amlodipine + Telmisartan is a fixed-dose combination of a calcium channel blocker (amlodipine) and an angiotensin II receptor blocker (telmisartan) that is indicated for the treatment of hypertension, either as:
- Initial therapy in patients whose blood pressure is likely to need multiple drugs to reach their blood pressure goal.
- Add-on/substitution therapy in patients who are not adequately controlled on amlodipine or telmisartan monotherapy alone.
Amlodipine + Telmisartan is not indicated as initial therapy for patients whose blood pressure may be controlled adequately with a single antihypertensive agent. Lowering blood pressure with Amlodipine + Telmisartan reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
Amlodipine + Telmisartan is not indicated for the initial management of hypertensive emergencies.
Dosage & Administration of Amlodipine + Telmisartan
Available Strengths
Amlodipine + Telmisartan tablets are typically supplied in the following telmisartan/amlodipine strength combinations: 40/5 mg, 40/10 mg, 80/5 mg, and 80/10 mg.
Dosing for Hypertension (Adults)
| Clinical situation | Recommended dose |
|---|---|
| Usual starting dose | Telmisartan/amlodipine 40 mg/5 mg once daily |
| Patients needing a larger initial reduction | 80 mg/5 mg once daily |
| Titration | Dose may be increased after at least 2 weeks, up to a maximum of 80 mg/10 mg once daily, based on blood pressure response |
| Patients switching from monotherapy | May be switched directly to a combination tablet containing an appropriate dose of the other component |
Most of the antihypertensive effect is generally seen within 2 weeks of starting or adjusting the dose.
Elderly (≥75 years) and Hepatic Impairment
Amlodipine + Telmisartan is not recommended for initial therapy in patients ≥75 years of age or in those with hepatic impairment; amlodipine 2.5 mg should be used as a starting dose in these patients, with slow titration.
Renal Impairment
No initial dosage adjustment of Amlodipine + Telmisartan is required in mild-to-moderate renal impairment; slower titration is advised in patients with severe renal impairment.
Pediatric Dosing
Safety and effectiveness of Amlodipine + Telmisartan in patients under 18 years of age have not been established (see Pediatric Uses).
Side Effects of Amlodipine + Telmisartan
Common Side Effects
- Peripheral (ankle/leg) edema
- Dizziness
- Headache
- Flushing
- Fatigue
- Back pain
- Upper respiratory tract infection symptoms
Less Common but Clinically Important Effects
- Symptomatic hypotension
- Hyperkalemia (elevated blood potassium)
- Palpitations
Rare but Serious Effects
- Angioedema (swelling of the face, lips, tongue, or throat) — rare but potentially life-threatening; requires immediate medical attention
- Rhabdomyolysis
- Significant liver enzyme abnormalities/hepatic dysfunction
- Worsening angina or myocardial infarction, particularly after starting or increasing the dose in patients with severe obstructive coronary artery disease
Patients should seek prompt medical attention for swelling of the face/throat, difficulty breathing, severe dizziness/fainting, chest pain, or irregular heartbeat while taking Amlodipine + Telmisartan.
Contraindications of Amlodipine + Telmisartan
Contraindications
- Known hypersensitivity to amlodipine, telmisartan, dihydropyridine calcium channel blockers, or any component of Amlodipine + Telmisartan.
- Pregnancy. Amlodipine + Telmisartan can cause injury and death to the developing fetus when used during pregnancy (see Pregnancy and Lactation); it must not be used in patients who are pregnant.
- Concomitant use with aliskiren in patients with diabetes mellitus — this combination is contraindicated due to an increased risk of hyperkalemia, hypotension, and renal impairment.
Frequently Asked Questions about Amlodipine + Telmisartan
What is Amlodipine + Telmisartan used for?
Amlodipine + Telmisartan is a combination medicine used to treat high blood pressure (hypertension), either as an initial treatment in patients likely to need more than one blood pressure medicine, or when blood pressure is not adequately controlled with a single agent.
Can I take Amlodipine + Telmisartan if I am pregnant or planning to become pregnant?
No. Amlodipine + Telmisartan is contraindicated in pregnancy because it can cause serious injury or death to the developing fetus. If you become pregnant while taking Amlodipine + Telmisartan, stop the medicine and contact your physician immediately so you can be switched to a pregnancy-appropriate alternative.
How should I take Amlodipine + Telmisartan?
Take Amlodipine + Telmisartan by mouth once daily, at about the same time each day, with or without food, and swallow the tablet whole with water. Do not stop taking it suddenly without talking to your doctor, even if you feel well, since high blood pressure often has no symptoms.
What are the most common side effects of Amlodipine + Telmisartan?
The most common side effects are swelling of the ankles or legs (peripheral edema), dizziness, headache, flushing, and back pain. Most are mild, but you should seek urgent medical care if you notice facial or throat swelling, severe dizziness, fainting, or chest pain.
Can I take Amlodipine + Telmisartan with other blood pressure medicines, NSAIDs, or potassium supplements?
Amlodipine + Telmisartan can interact with other antihypertensives (added blood-pressure-lowering effect), NSAIDs like ibuprofen (reduced effect and possible kidney strain), and potassium supplements or potassium-sparing diuretics (risk of high blood potassium). Always tell your doctor and pharmacist about every medicine and supplement you take before and during treatment with Amlodipine + Telmisartan.
Is Amlodipine + Telmisartan safe for elderly patients or those with liver or kidney problems?
Amlodipine + Telmisartan should generally not be used as a starting treatment in patients 75 years or older or in those with liver problems; treatment is usually started with a low dose of one component alone and increased slowly. Patients with severe kidney impairment also need slower dose increases and monitoring. Your doctor will individualize your dose based on your health status.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.