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Carbetocin: Brands, Price & Uses in Bangladesh
Carbetocin is a synthetic, long-acting analogue of oxytocin indicated for the prevention of postpartum hemorrhage (PPH) caused by uterine atony following delivery of the baby.
About Carbetocin
Indications of Carbetocin
Carbetocin is a synthetic, long-acting analogue of oxytocin indicated for the prevention of postpartum hemorrhage (PPH) caused by uterine atony following delivery of the baby.
Established/Approved Use
- Prevention of postpartum hemorrhage due to uterine atony following delivery of an infant, particularly after cesarean section performed under regional (spinal or epidural) or general anesthesia, given as a single dose immediately after delivery of the baby and before delivery of the placenta.
Guideline-Supported Use
- Some international guidelines (e.g., WHO) also support use of Carbetocin for prevention of PPH after vaginal delivery in appropriate hospital settings; local labeling and availability vary.
Carbetocin is not indicated for induction or augmentation of labor and must never be given before delivery of the baby.
Dosage & Administration of Carbetocin
Carbetocin is intended for use only by, or under the direct supervision of, a healthcare professional trained in obstetric care, in a setting where uterine tone and vital signs can be monitored.
| Indication | Dose | Route | Timing |
|---|---|---|---|
| Prevention of PPH after cesarean section | 100 micrograms, single dose | Slow intravenous injection over 1 minute (may also be given intramuscularly) | Immediately after delivery of the baby, before delivery of the placenta |
Only one dose of Carbetocin should be given; repeat dosing has not been established as safe or effective and is not recommended. Carbetocin must never be administered before the baby is delivered.
Side Effects of Carbetocin
Adverse effects of Carbetocin are generally transient and related to its oxytocic action.
Common
- Nausea, vomiting, abdominal pain
- Flushing, feeling of warmth
- Headache, dizziness, tremor
- Hypotension, transient tachycardia
- Pruritus (itching), chills
- Metallic taste
Less Common
- Chest pain, palpitations, dyspnea (shortness of breath)
- Anemia
- Back pain
Serious cardiovascular reactions (e.g., significant hypotension, arrhythmia) are uncommon but require prompt medical attention if they occur — see Precautions and Warnings.
Contraindications of Carbetocin
Carbetocin is contraindicated in:
- Known hypersensitivity to Carbetocin or any component of the formulation.
- Before delivery of the baby — Carbetocin must not be used to induce or augment labor, or at any time before the fetus is delivered, because it produces a sustained uterine contraction that can compromise the fetus and is inappropriate before birth.
- Situations in which oxytocic agents are generally contraindicated prior to delivery (e.g., significant cephalopelvic disproportion or unfavorable fetal position/presentation requiring surgical rather than vaginal delivery) — relevant only insofar as Carbetocin must never be given in the pre-delivery period.
Frequently Asked Questions about Carbetocin
What is Carbetocin used for?
Carbetocin is used to prevent postpartum hemorrhage (excessive bleeding) caused by uterine atony after childbirth, particularly following cesarean section.
When is Carbetocin given?
Carbetocin is given as a single injection immediately after the baby is delivered (and, during cesarean section, before the placenta is delivered). It must never be given before the baby is born.
Can Carbetocin be used to induce labor?
No. Carbetocin is not indicated for inducing or augmenting labor. It is intended only for use after delivery of the baby to prevent bleeding.
What are the common side effects of Carbetocin?
Common side effects of Carbetocin include nausea, vomiting, abdominal pain, flushing, headache, dizziness, tremor, and a temporary drop in blood pressure with a brief increase in heart rate. These effects are usually mild and short-lived.
Is Carbetocin safe while breastfeeding?
Only small amounts of Carbetocin are expected to pass into breast milk after a single postpartum dose, and significant effects on the breastfed infant are not expected; however, it should be used only if the potential benefit outweighs the potential risk, and a physician should be consulted regarding breastfeeding.
What should be done if too much Carbetocin is given?
An overdose of Carbetocin can cause excessive uterine contraction and pronounced side effects such as marked low blood pressure and rapid heartbeat. Immediate medical attention should be sought, as there is no specific antidote; treatment is supportive.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.