Arbecin100 mcg/ml

Arbecin 100 mcg/ml is indicated for the prevention of uterine atony and postpartum haemorrhage (excessive bleeding) following delivery of the infant by elective caesarean section under epidural or spinal anaesthesia.

Drugs acting on the Uterus

Arbecin 100 mcg/ml is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is an analogue of oxytocin, and its action is similar to that of oxytocin; it causes contraction of the uterus. Arbecin 100 mcg/ml binds to oxytocin receptors present on the smooth musculature of the uterus, resulting in rhythmic contractions of the uterus, increased frequency of existing contractions, and increased uterine tone. The oxytocin receptor content of the uterus is very low in the non-pregnant state, and increases during pregnancy, reaching a peak at the time of delivery.

A single intravenous dose of 100 mcg of Arbecin 100 mcg/ml injection is administered by bolus injection, slowly over 1 minute, only when infant delivery has been completed by caesarean section under epidural or spinal anaesthesia. Arbecin 100 mcg/ml is to be used as a single dose only.

A single intravenous dose of 100 mcg of Arbecin 100 mcg/ml injection is administered by bolus injection, slowly over 1 minute, only when infant delivery has been completed by caesarean section under epidural or spinal anaesthesia. Arbecin 100 mcg/ml is to be used as a single dose only.

No specific drug interactions have been reported with Arbecin 100 mcg/ml.

Because of its long duration of action relative to oxytocin, uterine contractions produced by Arbecin 100 mcg/ml cannot be stopped by simply discontinuing the medication. Therefore, Arbecin 100 mcg/ml should not be administered prior to delivery of the infant for any reason, including elective or medical induction of labour. Inappropriate use of Arbecin 100 mcg/ml during pregnancy could theoretically mimic the symptoms of oxytocin overdosage, including hyperstimulation of the uterus with strong (hypertonic) or prolonged (tetanic) contractions, tumultuous labour, uterine rupture, cervical and vaginal lacerations, postpartum haemorrhage, utero-placental hypoperfusion and variable deceleration of foetal heart, foetal hypoxia, hypercapnia, or death. Arbecin 100 mcg/ml should not be used in patients with a history of hypersensitivity to oxytocin or Arbecin 100 mcg/ml. Arbecin 100 mcg/ml should not be used in patients with cardio vascular disease, especially coronary artery disease, valvular heart disease, cardiomyopathy and heart failure. Arbecin 100 mcg/ml is not intended for use in children. 

10-40% of patients experienced nausea, vomiting, abdominal pain, itching skin, increased body temperature, trembling and weakness. Infrequent adverse events (1-5% of patients) included back pain, dizziness, metallic taste, anaemia, sweating, chest pain, dyspnoea, chills, tachycardia and anxiety.

Use of Arbecin 100 mcg/ml injection is contraindicated during pregnancy. Small amounts of Arbecin 100 mcg/ml has been shown to cross over from plasma into the breast milk of nursing women. The small amount of Arbecin 100 mcg/ml ingested by infant would not be expected to present a significant safety concern.

In patients who may not have an adequate uterine contraction after a single injection of Arbecin 100 mcg/ml, more aggressive treatment with additional doses of oxytocin or ergometrine is warranted. As Arbecin 100 mcg/ml is closely related in structure to oxytocin, hyponatraemia may occur. Arbecin 100 mcg/ml should be used cautiously in the presence of epilepsy, migraine, asthma or any state in which a rapid addition to extracellular water may produce hazard for an already overburdened system. Patients with eclampsia and pre-eclampsia should be monitored for changes in blood pressure. Arbecin 100 mcg/ml is not recommended for use in elderly patients.

Overdosage of Arbecin 100 mcg/ml can be expected to produce enhanced pharmacological effects associated with uterine hyperactivity and pain. Treatment consists of symptomatic and supportive management.

Store at 2-8°C. Do not freeze. Keep away from light. Once the ampoule has been opened, the product should be used immediately.

Drugs acting on the Uterus

Arbecin 100 mcg/ml is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is an analogue of oxytocin, and its action is similar to that of oxytocin; it causes contraction of the uterus. Arbecin 100 mcg/ml binds to oxytocin receptors present on the smooth musculature of the uterus, resulting in rhythmic contractions of the uterus, increased frequency of existing contractions, and increased uterine tone. The oxytocin receptor content of the uterus is very low in the non-pregnant state, and increases during pregnancy, reaching a peak at the time of delivery.

Use of Arbecin 100 mcg/ml injection is contraindicated during pregnancy. Small amounts of Arbecin 100 mcg/ml has been shown to cross over from plasma into the breast milk of nursing women. The small amount of Arbecin 100 mcg/ml ingested by infant would not be expected to present a significant safety concern.