Arbecin

Arbecin100 mcg/ml

IV Injection

Carbetocin

Renata Limited

Product Code : 1243
MRP 150.00
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Medicine overview

Indications of Arbecin 100 mcg/ml

Arbecin 100 mcg/ml is indicated for the prevention of uterine atony and postpartum haemorrhage (excessive bleeding) following delivery of the infant by elective caesarean section under epidural or spinal anaesthesia.

Theropeutic Class

Drugs acting on the Uterus

Pharmacology

Arbecin 100 mcg/ml is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is an analogue of oxytocin, and its action is similar to that of oxytocin; it causes contraction of the uterus. Arbecin 100 mcg/ml binds to oxytocin receptors present on the smooth musculature of the uterus, resulting in rhythmic contractions of the uterus, increased frequency of existing contractions, and increased uterine tone. The oxytocin receptor content of the uterus is very low in the non-pregnant state, and increases during pregnancy, reaching a peak at the time of delivery.

Dosage & Administration of Arbecin 100 mcg/ml

A single intravenous dose of 100 mcg of Arbecin 100 mcg/ml injection is administered by bolus injection, slowly over 1 minute, only when infant delivery has been completed by caesarean section under epidural or spinal anaesthesia. Arbecin 100 mcg/ml is to be used as a single dose only.

Dosage of Arbecin 100 mcg/ml

A single intravenous dose of 100 mcg of Arbecin 100 mcg/ml injection is administered by bolus injection, slowly over 1 minute, only when infant delivery has been completed by caesarean section under epidural or spinal anaesthesia. Arbecin 100 mcg/ml is to be used as a single dose only.

Interaction of Arbecin 100 mcg/ml

No specific drug interactions have been reported with Arbecin 100 mcg/ml.

Contraindications

Because of its long duration of action relative to oxytocin, uterine contractions produced by Arbecin 100 mcg/ml cannot be stopped by simply discontinuing the medication. Therefore, Arbecin 100 mcg/ml should not be administered prior to delivery of the infant for any reason, including elective or medical induction of labour. Inappropriate use of Arbecin 100 mcg/ml during pregnancy could theoretically mimic the symptoms of oxytocin overdosage, including hyperstimulation of the uterus with strong (hypertonic) or prolonged (tetanic) contractions, tumultuous labour, uterine rupture, cervical and vaginal lacerations, postpartum haemorrhage, utero-placental hypoperfusion and variable deceleration of foetal heart, foetal hypoxia, hypercapnia, or death. Arbecin 100 mcg/ml should not be used in patients with a history of hypersensitivity to oxytocin or Arbecin 100 mcg/ml. Arbecin 100 mcg/ml should not be used in patients with cardio vascular disease, especially coronary artery disease, valvular heart disease, cardiomyopathy and heart failure. Arbecin 100 mcg/ml is not intended for use in children. 

Side Effects of Arbecin 100 mcg/ml

10-40% of patients experienced nausea, vomiting, abdominal pain, itching skin, increased body temperature, trembling and weakness. Infrequent adverse events (1-5% of patients) included back pain, dizziness, metallic taste, anaemia, sweating, chest pain, dyspnoea, chills, tachycardia and anxiety.

Pregnancy & Lactation

Use of Arbecin 100 mcg/ml injection is contraindicated during pregnancy. Small amounts of Arbecin 100 mcg/ml has been shown to cross over from plasma into the breast milk of nursing women. The small amount of Arbecin 100 mcg/ml ingested by infant would not be expected to present a significant safety concern.

Precautions & Warnings

In patients who may not have an adequate uterine contraction after a single injection of Arbecin 100 mcg/ml, more aggressive treatment with additional doses of oxytocin or ergometrine is warranted. As Arbecin 100 mcg/ml is closely related in structure to oxytocin, hyponatraemia may occur. Arbecin 100 mcg/ml should be used cautiously in the presence of epilepsy, migraine, asthma or any state in which a rapid addition to extracellular water may produce hazard for an already overburdened system. Patients with eclampsia and pre-eclampsia should be monitored for changes in blood pressure. Arbecin 100 mcg/ml is not recommended for use in elderly patients.

Overdose Effects of Arbecin 100 mcg/ml

Overdosage of Arbecin 100 mcg/ml can be expected to produce enhanced pharmacological effects associated with uterine hyperactivity and pain. Treatment consists of symptomatic and supportive management.

Storage Conditions

Store at 2-8°C. Do not freeze. Keep away from light. Once the ampoule has been opened, the product should be used immediately.

Drug Classes

Drugs acting on the Uterus

Mode Of Action

Arbecin 100 mcg/ml is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is an analogue of oxytocin, and its action is similar to that of oxytocin; it causes contraction of the uterus. Arbecin 100 mcg/ml binds to oxytocin receptors present on the smooth musculature of the uterus, resulting in rhythmic contractions of the uterus, increased frequency of existing contractions, and increased uterine tone. The oxytocin receptor content of the uterus is very low in the non-pregnant state, and increases during pregnancy, reaching a peak at the time of delivery.

Pregnancy

Use of Arbecin 100 mcg/ml injection is contraindicated during pregnancy. Small amounts of Arbecin 100 mcg/ml has been shown to cross over from plasma into the breast milk of nursing women. The small amount of Arbecin 100 mcg/ml ingested by infant would not be expected to present a significant safety concern.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.