8% Off
Clinface1.2%+0.025
Square Pharmaceuticals PLC.
৳138.94
Add to cart
Generic medicine
Clindamycin + Tretinoin: Brands, Price & Uses in Bangladesh
Clindamycin + Tretinoin is a fixed-dose topical combination of a lincosamide antibiotic (clindamycin) and a retinoid (tretinoin) indicated for the treatment of acne vulgaris.
About Clindamycin + Tretinoin
Indications of Clindamycin + Tretinoin
Clindamycin + Tretinoin is a fixed-dose topical combination of a lincosamide antibiotic (clindamycin) and a retinoid (tretinoin) indicated for the treatment of acne vulgaris.
Established/Approved Use
- Acne vulgaris: Clindamycin + Tretinoin gel is FDA-approved and widely used for the topical treatment of acne vulgaris in patients 12 years of age and older. It combines the antibacterial and anti-inflammatory action of clindamycin against Cutibacterium acnes with the comedolytic (pore-unclogging) action of tretinoin, which normalizes follicular keratinization.
Not Indicated / Off-Label
Clindamycin + Tretinoin is not indicated for inflammatory conditions other than acne vulgaris (e.g., rosacea, perioral dermatitis) and is not intended for oral, ophthalmic, or intravaginal use. Use for any purpose other than topical acne treatment is off-label and not recommended without physician guidance.
Dosage & Administration of Clindamycin + Tretinoin
Adult and Adolescent Dosing (12 years and older)
| Indication | Dose/Application | Frequency |
|---|---|---|
| Acne vulgaris | Apply a pea-sized amount to cover the entire affected area (typically the face) in a thin layer | Once daily, at bedtime, on clean, dry skin |
Administration Instructions
- Wash the affected area gently with a mild cleanser and pat dry; wait 20–30 minutes before application to reduce irritation.
- Apply a thin film, avoiding the eyes, lips, angles of the nose, and mucous membranes.
- Wash hands after application.
- Avoid application to cuts, abrasions, sunburned, or eczematous skin.
- Not for oral, ophthalmic, or intravaginal use.
- Take exactly as prescribed by your physician; do not stop, extend, skip doses, or share this medicine with others without medical advice.
Clinical improvement in acne is usually seen after several weeks of continuous use; treatment duration should be guided by a physician.
Side Effects of Clindamycin + Tretinoin
The most common adverse effects of Clindamycin + Tretinoin are local skin reactions, which are usually mild to moderate and tend to peak within the first two weeks of treatment before improving:
- Erythema (redness)
- Dryness and scaling/peeling
- Burning or stinging sensation
- Pruritus (itching)
- Application site irritation
Less common systemic effects reported include nasopharyngitis, pharyngolaryngeal pain, cough, and sinusitis, which may reflect background incidence rather than a direct drug effect.
Rare but serious: Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with topical clindamycin due to limited systemic absorption. See Contraindications and Precautions for more detail; discontinue and seek medical attention if significant diarrhea occurs.
Contraindications of Clindamycin + Tretinoin
Clindamycin + Tretinoin is contraindicated in patients with:
- Known hypersensitivity to clindamycin, lincomycin, tretinoin, or any component of the formulation.
- A history of regional enteritis (Crohn's disease), ulcerative colitis, or antibiotic-associated colitis (including pseudomembranous colitis).
Frequently Asked Questions about Clindamycin + Tretinoin
What is Clindamycin + Tretinoin used for?
Clindamycin + Tretinoin is a topical gel used to treat acne vulgaris. It combines an antibiotic (clindamycin) that reduces acne-causing bacteria and inflammation with a retinoid (tretinoin) that unclogs pores and normalizes skin cell turnover.
How should I apply Clindamycin + Tretinoin?
Apply a pea-sized amount of Clindamycin + Tretinoin gel once daily at bedtime to clean, dry skin, covering the entire affected area in a thin layer. Avoid the eyes, mouth, and mucous membranes, and wash your hands after application.
Can Clindamycin + Tretinoin be used during pregnancy?
Clindamycin + Tretinoin contains tretinoin, a retinoid, and retinoids carry teratogenicity concerns as a class. It should be used during pregnancy only if the potential benefit clearly justifies the potential risk to the fetus, and only under a physician's guidance. Discuss any pregnancy plans or pregnancy with your doctor before using Clindamycin + Tretinoin.
What side effects can occur with Clindamycin + Tretinoin?
The most common side effects of Clindamycin + Tretinoin are local skin reactions such as redness, dryness, peeling, burning, or itching, especially in the first couple of weeks of use. Rarely, topical clindamycin absorption can cause severe diarrhea or colitis; stop use and see a doctor promptly if this occurs.
Who should not use Clindamycin + Tretinoin?
Clindamycin + Tretinoin should not be used by people who are hypersensitive to clindamycin, lincomycin, or tretinoin, or who have a history of regional enteritis (Crohn's disease), ulcerative colitis, or antibiotic-associated colitis.
Do I need sun protection while using Clindamycin + Tretinoin?
Yes. The tretinoin component of Clindamycin + Tretinoin increases skin sensitivity to sunlight and UV light. Use a broad-spectrum sunscreen daily, wear protective clothing, and avoid excessive sun exposure or tanning beds while using this medicine.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.