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Dalacin Plus1.2%+0.025%
Topical Gel
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Medicine overview
Indications of Dalacin Plus 1.2%+0.025%
Clindamycin and Tretinoin gel is indicated for the topical treatment of Acne vulgaris.
Theropeutic Class
Topical antibiotic & retinoid preparations
Pharmacology
This is a combination of lincosamide antibiotic Clindamycin phosphate and retinoid Tretinoin.
Absorption
Clindamycin binds with the 50s ribosomal subunit of susceptible bacteria and prevents elongation of peptide chain by interfering with the peptidyl transfer, thereby suppressing bacterial protein synthesis.
Distribution
Clindamycin inhibits the activity of Propionibacterium acne as reduces the occurrence of acne.
Metabolism
Tretinoin decreases the cohesiveness of follicular epithelial cells and increases the turn over thereby brings the comedones out.
Dosage & Administration of Dalacin Plus 1.2%+0.025%
Before sleep
Dosage:Wash the face gently with a mild soap and water, then pat the skin dry
Notes:Apply the Gel with finger tips through the face gently
In the morning
Dosage:Apply a sunscreen after the application of Gel
Notes:Do not wash your face more than 2 or 3 times a day. Apply the sunscreen cream as needed
| Condition | Dosage | Notes |
|---|---|---|
| Before sleep | Wash the face gently with a mild soap and water, then pat the skin dry | Apply the Gel with finger tips through the face gently |
| In the morning | Apply a sunscreen after the application of Gel | Do not wash your face more than 2 or 3 times a day. Apply the sunscreen cream as needed |
Dosage of Dalacin Plus 1.2%+0.025%
Before sleep
Dosage:Wash the face gently with a mild soap and water, then pat the skin dry
Notes:Apply the Gel with finger tips through the face gently
In the morning
Dosage:Apply a sunscreen after the application of Gel
Notes:Do not wash your face more than 2 or 3 times a day. Apply the sunscreen cream as needed. Safety and effectiveness in children below 12 years of age have not been established
| Condition | Dosage | Notes |
|---|---|---|
| Before sleep | Wash the face gently with a mild soap and water, then pat the skin dry | Apply the Gel with finger tips through the face gently |
| In the morning | Apply a sunscreen after the application of Gel | Do not wash your face more than 2 or 3 times a day. Apply the sunscreen cream as needed. Safety and effectiveness in children below 12 years of age have not been established |
Interaction of Dalacin Plus 1.2%+0.025%
Concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, products with high concentrations of alcohol, astringents, spices or lime) should be approached with caution.
While using concomitantly with Erythromycin, the activity of both Clindamycin and Erythromycin are decreased. So, Clindamycin should not be used with Erythromycin concomitantly.
While using concomitantly with neuromuscular medicine, the activity of the neuromuscular medicine is increased. So, care should be taken during these concomitant uses.
Contraindications
Clindamycin and Tretinoin should not be administered to individuals who are hypersensitive to Clindamycin or Tretinoin or any other component of the Gel.
Side Effects of Dalacin Plus 1.2%+0.025%
Erythema, scaling, nasopharyngitis, dry skin, cough, sinusitis and diarrhea are the common side effects.
Pregnancy & Lactation
It is not known whether Clindamycin or Tretinoin is excreted in human milk. Exercise special caution while applying Clindamycin or Tretinoin to a nursing mother.
Precautions & Warnings
Clindamycin and Tretinoin should not be applied to eyes, nose, ear, lips, cut, burn and other infections. After the application of the Gel, keep away from sunlight.
Storage Conditions
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.
Use In Special Populations
Safety and effectiveness in children below 12 years of age have not been established.
Drug Classes
Topical antibiotic & retinoid preparations
Mode Of Action
This is a combination of lincosamide antibiotic Clindamycin phosphate and retinoid Tretinoin. Clindamycin binds with the 50s ribosomal subunit of susceptible bacteria and prevents elongation of peptide chain by interfering with the peptidyl transfer, thereby suppressing bacterial protein synthesis. Clindamycin inhibits the activity of Propionibacterium acne as reduces the occurrence of acne. Tretinoin decreases the cohesiveness of follicular epithelial cells and increases the turn over thereby brings the comedones out.
Pregnancy
It is not known whether Clindamycin or Tretinoin is excreted in human milk. Exercise special caution while applying Clindamycin or Tretinoin to a nursing mother.
Frequently Asked Questions
What is Dalacin Plus 1.2%+0.025% used for?
Clindamycin and Tretinoin gel is indicated for the topical treatment of Acne vulgaris.
What is the dosage of Dalacin Plus 1.2%+0.025%?
Before sleep: Wash the face gently with a mild soap and water, then pat the skin dry. Apply the Gel with finger tips through the face gently.In the morning: Apply a sunscreen after the application of Gel. Do not wash your face more than 2 or 3 times a day. Apply the sunscreen cream as needed.Safety and effectiveness in children below 12 years of age have not been established.
What are the side effects of Dalacin Plus 1.2%+0.025%?
Erythema, scaling, nasopharyngitis, dry skin, cough, sinusitis and diarrhea are the common side effects.
Who should not take Dalacin Plus 1.2%+0.025%?
Clindamycin and Tretinoin should not be administered to individuals who are hypersensitive to Clindamycin or Tretinoin or any other component of the Gel.
What precautions should be taken with Dalacin Plus 1.2%+0.025%?
Clindamycin and Tretinoin should not be applied to eyes, nose, ear, lips, cut, burn and other infections. After the application of the Gel, keep away from sunlight.
Is Dalacin Plus 1.2%+0.025% safe during pregnancy and breastfeeding?
It is not known whether Clindamycin or Tretinoin is excreted in human milk. Exercise special caution while applying Clindamycin or Tretinoin to a nursing mother.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.