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Dexibuprofen: Brands, Price & Uses in Bangladesh
Dexibuprofen is a nonsteroidal anti-inflammatory drug (NSAID), the active dextrorotatory (S(+)) enantiomer of racemic ibuprofen and more.
About Dexibuprofen
Indications of Dexibuprofen
Dexibuprofen is a nonsteroidal anti-inflammatory drug (NSAID), the active dextrorotatory (S(+)) enantiomer of racemic ibuprofen, indicated for the relief of pain and inflammation in a range of acute and chronic musculoskeletal and other conditions.
Established / Guideline-Supported Uses
- Symptomatic relief of pain and inflammation in osteoarthritis
- Symptomatic relief of pain, stiffness and inflammation in rheumatoid arthritis and other inflammatory arthropathies
- Mild to moderate musculoskeletal and soft-tissue pain (sprains, strains, back pain)
- Dental pain, including post-extraction pain
- Primary dysmenorrhoea (painful menstrual periods)
- Postoperative pain of mild to moderate intensity
- Fever and pain associated with common febrile/painful conditions in adults, as an analgesic-antipyretic
Adjunct Use
In chronic inflammatory joint disease, Dexibuprofen is often used as an adjunct to disease-modifying therapy for symptom control rather than as a disease-modifying agent itself.
Dosage & Administration of Dexibuprofen
Adult Dosage by Indication
| Indication | Typical Adult Dose |
|---|---|
| Osteoarthritis / Rheumatoid arthritis | 200–400 mg two to three times daily |
| Mild-to-moderate pain (musculoskeletal, dental, postoperative) | 200–400 mg every 4–6 hours as needed |
| Primary dysmenorrhoea | 200–400 mg every 4–6 hours as needed, starting at onset of symptoms |
Maximum recommended total daily dose is generally 1200 mg, though some prescribers limit chronic use to lower totals. The lowest effective dose should be used for the shortest duration consistent with treatment goals (see Precautions and Warnings for cardiovascular and gastrointestinal risk).
Renal/Hepatic Impairment
Use with caution and at the lowest effective dose in mild-to-moderate renal or hepatic impairment; Dexibuprofen is contraindicated in severe renal or hepatic impairment (see Contraindications).
Pediatric Dosage
Safety and efficacy of Dexibuprofen have not been well established in children; it is generally not recommended for pediatric use (see Use in Special Populations).
Side Effects of Dexibuprofen
Common
- Gastrointestinal upset, dyspepsia, nausea, heartburn
- Headache
- Dizziness
Less Common but Clinically Important
- Gastrointestinal ulceration and bleeding
- Renal impairment or fluid retention
- Hypertension or worsening of existing hypertension
- Peripheral edema
- Skin rash or hypersensitivity reactions
Serious cardiovascular thrombotic events (heart attack, stroke) and serious gastrointestinal events (bleeding, ulceration, perforation) can occur at any time during use of Dexibuprofen, with or without warning symptoms, and risk increases with duration of use (see Precautions and Warnings).
Contraindications of Dexibuprofen
Dexibuprofen is contraindicated in patients with:
- Known hypersensitivity to Dexibuprofen, other NSAIDs, or aspirin, including a history of bronchospasm, urticaria, angioedema, or other allergic-type reactions to these agents (NSAID-induced asthma)
- Active peptic ulcer disease or active gastrointestinal bleeding
- Severe heart failure
- Third trimester of pregnancy
- Severe renal impairment
- Severe hepatic impairment
Frequently Asked Questions about Dexibuprofen
What is Dexibuprofen used for?
Dexibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, musculoskeletal injuries, dental pain, and painful menstrual periods (dysmenorrhoea).
How should I take Dexibuprofen?
Dexibuprofen is usually taken orally, 200–400 mg two to three times a day, preferably with food or milk to reduce stomach upset, and should not exceed a total daily dose of 1200 mg unless directed otherwise by your physician. Always follow your doctor's or pharmacist's specific instructions.
Can I take Dexibuprofen during pregnancy?
Dexibuprofen should be avoided during the third trimester of pregnancy because it can cause premature closure of a blood vessel in the fetal heart (ductus arteriosus) and reduce amniotic fluid. In earlier pregnancy, Dexibuprofen should be used only if clearly needed, at the lowest effective dose, and after consulting a physician, since the potential benefit must justify the potential risk to the fetus.
Who should not take Dexibuprofen?
Dexibuprofen should not be taken by people who are allergic to Dexibuprofen, other NSAIDs, or aspirin (including those with a history of asthma, hives, or swelling triggered by these medicines), or by those with active stomach ulcers or bleeding, severe heart failure, severe kidney or liver impairment, or who are in the third trimester of pregnancy.
What are the common side effects of Dexibuprofen?
The most common side effects of Dexibuprofen include stomach upset, indigestion, nausea, headache, and dizziness. Less commonly, Dexibuprofen can cause more serious effects such as stomach bleeding, kidney problems, or high blood pressure, so report any unusual symptoms to your doctor promptly.
Can Dexibuprofen be taken with other painkillers or blood thinners?
Dexibuprofen should not be combined with other NSAIDs or aspirin, as this increases the risk of stomach bleeding without added benefit. Combining Dexibuprofen with blood thinners (anticoagulants) also raises bleeding risk significantly. Always tell your doctor about all medicines you are taking before starting Dexibuprofen.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.