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Dextrose5%
Opso Saline Ltd.
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Generic medicine
Dextrose: Brands, Price & Uses in Bangladesh
Dextrose (dextrose monohydrate) solutions are used for the following indications, listed by strength of evidence: Established / FDA-approved uses (intravenous) Source of calories and free water for…
About Dextrose
Indications of Dextrose
Dextrose (dextrose monohydrate) solutions are used for the following indications, listed by strength of evidence:
Established / FDA-approved uses (intravenous)
- Source of calories and free water for patients who cannot take adequate oral fluids/nutrition (e.g. peri-operative, critically ill, or NPO patients) — typically 5% Dextrose solutions.
- Treatment of hypoglycemia, including severe/symptomatic hypoglycemia (e.g. insulin overdose, prolonged fasting) — typically 10–50% Dextrose solutions given as IV infusion or slow IV push.
- Diluent/vehicle for administering compatible IV medications and for reconstituting/diluting other injectable drugs.
- Component of parenteral nutrition (TPN) regimens, where higher-concentration Dextrose (e.g. 20–70%) supplies non-protein calories, usually via a central venous line.
Guideline-supported adjunct use
- Emergency management of hyperkalemia, given together with regular insulin (insulin–Dextrose infusion) to shift potassium intracellularly while insulin is administered — this is an adjunct, combination-therapy use and does not lower total body potassium.
Oral use
- Oral glucose (dextrose) solution is used for mild-to-moderate hypoglycemia in a conscious patient able to swallow, and as the standard glucose load for an oral glucose tolerance test (OGTT) used to screen for diabetes/gestational diabetes.
The specific concentration and route (IV vs. oral) used depend on the clinical indication and must be selected by a physician; see Dosage and Administration.
Dosage & Administration of Dextrose
Dextrose dosing is individualised by indication, concentration, patient age, weight, fluid/electrolyte status, and clinical response, and IV use requires monitoring by a physician or under medical supervision.
| Indication | Typical adult dosing | Notes |
|---|---|---|
| Fluid/caloric maintenance | 5% Dextrose: 500–1000 mL IV infusion, rate individualised; usually not exceeding 0.5 g/kg/hour to avoid glycosuria | May be given via peripheral vein |
| Moderate fluid/carbohydrate depletion | 10% Dextrose: dose and rate individualised (e.g. up to 20–30 mL/kg over the prescribed period) per clinical status | Peripheral vein may be used cautiously; watch for irritation |
| Severe/symptomatic hypoglycemia | 10–50% Dextrose IV; a common regimen is 25 g (50 mL of 50% Dextrose) by slow IV push, or continuous infusion of a lower concentration until glucose stabilises | Recheck blood glucose after treatment; higher concentrations (>12.5%) generally require a large peripheral or central vein |
| Hyperkalemia (adjunct) | Dextrose (e.g. 25–50 g) given with regular insulin (commonly 5–10 units) by IV infusion | Combination therapy only; monitor blood glucose and potassium closely; see Precautions |
| Parenteral nutrition component | Higher concentrations (20–70%) as part of an individualised TPN prescription | Concentrations >10–12.5% (osmolarity ≥900 mOsm/L) generally require central venous administration |
| Oral hypoglycemia treatment | 10–20 g oral Dextrose as a single dose; may repeat once after about 10–15 minutes if symptoms/low glucose persist | Only for a conscious patient able to swallow safely |
| Oral glucose tolerance test | Standard oral Dextrose load per the testing protocol in use (physician/laboratory directed) | Test-specific; follow local protocol |
Renal/hepatic impairment: use with caution and closer monitoring of glucose, fluid, and electrolyte status in renal or hepatic impairment; no fixed dose-reduction schedule is established — the prescribing physician individualises the rate and concentration.
Side Effects of Dextrose
The most commonly reported adverse reactions with Dextrose infusion are:
- Hyperglycemia and, if severe or prolonged, glycosuria/osmotic diuresis.
- Hypersensitivity/infusion reactions — rash, urticaria, and rarely anaphylaxis, angioedema, or bronchospasm.
- Hyponatremia, which can be severe, particularly with large-volume infusion.
- Local reactions at the infusion site — pain, redness, irritation, phlebitis, and thrombosis, especially with higher-concentration solutions given peripherally.
- Infection at the injection site or systemically, related to IV access.
- Electrolyte imbalance (e.g. hypokalemia, hypophosphatemia) and, with excessive/rapid administration, fluid overload which can lead to pulmonary edema.
Oral Dextrose is generally well tolerated; mild nausea or gastrointestinal discomfort may occasionally occur.
Seek prompt medical attention for signs of a serious reaction (difficulty breathing, swelling of the face/throat, chest pain, severe confusion) during or after Dextrose administration.
Contraindications of Dextrose
Dextrose is contraindicated in:
- Patients with known hypersensitivity to Dextrose (dextrose) or to any component of the formulation.
- Patients with clinically significant hyperglycemia that is uncontrolled, until the hyperglycemia is addressed.
Diabetes, fluid-overload-prone conditions, and electrolyte disturbances are important precautions requiring caution and monitoring, not absolute contraindications — see Precautions and Warnings.
Frequently Asked Questions about Dextrose
What is Dextrose used for?
Dextrose (dextrose monohydrate) solutions are mainly used intravenously to provide fluids and calories, to treat low blood sugar (hypoglycemia), as a vehicle for other IV medicines, and as part of nutrition support; a related oral form is used for mild hypoglycemia and for glucose tolerance testing.
Is Dextrose the same as sugar?
Yes, Dextrose is medical-grade D-glucose, the same simple sugar the body normally uses for energy, but it is manufactured and packaged as a sterile solution/powder suitable for injection or supervised oral use.
Can Dextrose be given at home?
Intravenous Dextrose must be given in a hospital or clinical setting by a healthcare professional, with monitoring of blood glucose, fluids, and electrolytes; it should never be self-administered intravenously at home. Oral Dextrose for mild hypoglycemia may be used at home only as directed by a physician.
Is Dextrose safe for diabetic patients?
Dextrose can be used in diabetic patients when clinically indicated (for example, to treat hypoglycemia from too much insulin), but it must be given cautiously with frequent blood glucose monitoring, because Dextrose itself raises blood sugar and may require adjustment of insulin or other diabetes medicines.
What are the main risks of Dextrose infusion?
The main risks are high blood sugar (hyperglycemia), low blood sodium (hyponatremia), fluid overload, and irritation or clotting of the vein (phlebitis/thrombosis) at the infusion site, especially with more concentrated solutions. These risks are minimised through physician-directed dosing and monitoring.
What should I do if I think I have received too much Dextrose?
If excessive or too-rapid Dextrose administration is suspected, tell the healthcare team immediately so the infusion can be stopped or adjusted; if you develop symptoms such as severe confusion, breathing difficulty, or chest pain after leaving a healthcare facility, seek immediate medical attention or contact emergency services/a poison control center rather than trying to manage it at home.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.