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Eperisone Hydrochloride: Brands, Price & Uses in Bangladesh
Eperisone Hydrochloride is a centrally-acting skeletal muscle relaxant used for the symptomatic relief of muscle spasm, spasticity and more.
About Eperisone Hydrochloride
Indications of Eperisone Hydrochloride
Eperisone Hydrochloride is a centrally-acting skeletal muscle relaxant used for the symptomatic relief of muscle spasm, spasticity, and stiffness associated with a range of musculoskeletal and neurological conditions. Its use is supported by clinical experience and regulatory approval in several countries, though it is not FDA-approved in the United States.
- Established uses:
- Relief of muscle spasm/tension associated with cervical spondylosis, lumbar spondylosis, and periarthritis of the shoulder (frozen shoulder/shoulder-arm-neck syndrome)
- Low back pain (lumbago) with associated muscle spasm
- Spastic paralysis due to cerebrovascular disease, cervical spondylotic myelopathy, and sequelae of spinal cord injury or head trauma
- Guideline-supported/adjunct uses: Used as an adjunct to physiotherapy, rest, and analgesics in the overall management of painful musculoskeletal spasm; also used as an adjunct in spasticity associated with neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), cerebral palsy, and spinocerebellar degeneration, alongside condition-specific therapy.
- Not a substitute for underlying treatment: Eperisone Hydrochloride relieves the muscular symptom but does not treat the underlying neurological or structural cause; a physician should evaluate and manage the primary condition.
Dosage & Administration of Eperisone Hydrochloride
Dosage of Eperisone Hydrochloride should be individualized according to the indication, severity of symptoms, and patient response.
| Population/Indication | Typical Dose |
|---|---|
| Adults - muscle spasm/spasticity (cervical spondylosis, lumbago, shoulder-arm-neck syndrome, spastic paralysis) | 50 mg orally three times daily after meals (total 150 mg/day), adjusted according to age, symptom severity, and response |
| Elderly | Start at the lower end of the adult dose range with close monitoring; see Use in Special Populations |
| Pediatric | Safety and efficacy not established; not recommended (see Pediatric Uses) |
| Hepatic impairment | Use with caution; dose reduction and closer monitoring may be warranted as the drug is hepatically metabolized |
| Renal impairment | Use with caution; no well-established dose adjustment schedule exists, so clinical monitoring is advised |
Tablets should be swallowed whole with water, preferably after meals, to reduce the likelihood of gastrointestinal upset.
Side Effects of Eperisone Hydrochloride
Side effects reported with Eperisone Hydrochloride are generally mild, but rare serious reactions can occur.
| Frequency | Effects |
|---|---|
| Common | Drowsiness, dizziness, nausea, anorexia, vomiting, diarrhoea, indigestion, skin rash |
| Uncommon/Rare | Muscle weakness, urinary dysfunction (e.g., urinary retention), disturbance of visual accommodation, mild elevations in liver enzymes |
| Rare but serious | Anaphylactoid/hypersensitivity reactions (including rash, swelling, breathing difficulty), blood dyscrasias (e.g., anaemia), seizures (reported in cases of overdose, including in infants) |
Patients should seek prompt medical attention if signs of a serious allergic reaction, unusual bruising/bleeding, or marked muscle weakness occur.
Contraindications of Eperisone Hydrochloride
Eperisone Hydrochloride is contraindicated in patients with known hypersensitivity to eperisone hydrochloride or to any component of the formulation.
Frequently Asked Questions about Eperisone Hydrochloride
What is Eperisone Hydrochloride used for?
Eperisone Hydrochloride is a centrally-acting muscle relaxant used to relieve muscle spasm, stiffness, and spasticity associated with conditions such as cervical or lumbar spondylosis, low back pain, shoulder-arm-neck syndrome, and spastic paralysis from certain neurological conditions.
How should I take Eperisone Hydrochloride?
Eperisone Hydrochloride is usually taken as a 50 mg tablet three times daily after meals, swallowed whole with water. Always follow your physician's specific dosing instructions.
Can Eperisone Hydrochloride make me feel drowsy?
Yes, Eperisone Hydrochloride can cause drowsiness or dizziness in some people. Avoid driving or operating machinery until you know how it affects you.
Is Eperisone Hydrochloride safe during pregnancy or breastfeeding?
Safety in pregnancy has not been well established; it should be used only if clearly needed and if the benefit justifies the potential risk to the fetus, after consulting a physician. It is not known whether it passes into breast milk, so it should be avoided during breastfeeding unless a doctor determines the benefit outweighs the risk.
Who should not take Eperisone Hydrochloride?
Eperisone Hydrochloride is contraindicated in anyone with a known hypersensitivity to eperisone hydrochloride or any ingredient in the formulation.
What should I do if I take too much Eperisone Hydrochloride?
An overdose of Eperisone Hydrochloride can cause marked drowsiness, muscle weakness, low blood pressure, and, especially in young children, seizures. Seek immediate medical attention or contact emergency services/a poison control center right away.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.