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Flurbiprofen: Brands, Price & Uses in Bangladesh
Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for the following indications: Established (oral/systemic) uses Relief of the signs and symptoms of osteoarthritis Relief of the…
About Flurbiprofen
Indications of Flurbiprofen
Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for the following indications:
Established (oral/systemic) uses
- Relief of the signs and symptoms of osteoarthritis
- Relief of the signs and symptoms of rheumatoid arthritis
- Management of mild-to-moderate acute pain
- Treatment of primary dysmenorrhea (menstrual pain)
Established (ophthalmic) use
- Ophthalmic Flurbiprofen solution is indicated to inhibit intraoperative miosis (pupil constriction) during cataract and other ocular surgery
Use of Flurbiprofen for indications not listed above is not established and should only be undertaken on a physician's advice.
Dosage & Administration of Flurbiprofen
Dosage of Flurbiprofen should be individualized to the lowest effective dose for the shortest duration consistent with the patient's treatment goals.
| Indication | Typical Adult Dosage |
|---|---|
| Osteoarthritis / Rheumatoid arthritis | Total daily dose of 200-300 mg orally, given in 2-4 divided doses; maximum single dose 100 mg; maximum total daily dose 300 mg |
| Mild-to-moderate pain / Primary dysmenorrhea | 50 mg orally every 4-6 hours as needed |
| Ophthalmic (miosis prevention) | One drop of ophthalmic Flurbiprofen solution instilled in the operative eye approximately every 30 minutes beginning several hours before surgery, per the specific product's approved schedule |
Pediatric: Safety and efficacy of oral Flurbiprofen have not been established in children; it should not be used in the pediatric population outside specialist guidance.
Renal/hepatic impairment: Use the lowest effective dose with caution and close monitoring; avoid in severe renal or hepatic impairment (see Use in Special Populations).
Oral tablets should be taken with food, milk, or an antacid to reduce gastrointestinal irritation, with a full glass of water, and the patient should remain upright for 15-30 minutes after dosing.
Side Effects of Flurbiprofen
Common and serious side effects associated with Flurbiprofen include:
Common
- Dyspepsia, nausea, abdominal pain, heartburn
- Headache, dizziness
- Fluid retention/edema
Serious (less common)
- Gastrointestinal ulceration, bleeding, or perforation
- Cardiovascular thrombotic events (myocardial infarction, stroke)
- Renal impairment/acute kidney injury
- Hepatotoxicity
- Hypersensitivity reactions including bronchospasm and anaphylaxis
- Skin reactions (rash, photosensitivity, rarely severe reactions such as Stevens-Johnson syndrome)
Ophthalmic Flurbiprofen may cause transient burning/stinging, mild ocular irritation, and, rarely, delayed corneal healing.
Contraindications of Flurbiprofen
Flurbiprofen is contraindicated in:
- Known hypersensitivity to Flurbiprofen or any component of the formulation
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs (due to cross-reactivity)
- Perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
- Third trimester of pregnancy
- Active gastrointestinal bleeding or active peptic ulcer disease
Frequently Asked Questions about Flurbiprofen
What is Flurbiprofen used for?
Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve the signs and symptoms of osteoarthritis and rheumatoid arthritis, to manage mild-to-moderate pain, and to treat primary dysmenorrhea (menstrual pain). An ophthalmic form of Flurbiprofen is also used to prevent pupil constriction during eye surgery.
Can I take Flurbiprofen with other pain relievers like aspirin or ibuprofen?
No. Combining Flurbiprofen with aspirin or other NSAIDs increases the risk of stomach bleeding and ulcers without added pain relief benefit, and may reduce aspirin's heart-protective effect. Avoid taking them together unless specifically advised by your physician.
Is Flurbiprofen safe during pregnancy?
Flurbiprofen should be used in early pregnancy only if clearly needed, after consulting a physician, and is contraindicated in the third trimester because it can cause premature closure of a blood vessel in the fetal heart (ductus arteriosus) and other complications. Always consult your doctor before using Flurbiprofen if you are pregnant.
What are the most serious side effects of Flurbiprofen?
Flurbiprofen can, in rare cases, cause serious gastrointestinal bleeding or ulceration, cardiovascular events such as heart attack or stroke, kidney problems, and allergic reactions. Seek medical attention immediately if you experience black or bloody stools, chest pain, sudden weakness, severe stomach pain, or difficulty breathing while taking Flurbiprofen.
Who should not take Flurbiprofen?
Flurbiprofen should not be used by people with known hypersensitivity to Flurbiprofen or other NSAIDs, those with a history of asthma or allergic reactions triggered by aspirin/NSAIDs, patients having coronary artery bypass graft (CABG) surgery, women in the third trimester of pregnancy, and people with active gastrointestinal bleeding or peptic ulcer disease.
What should I do if I miss a dose of Flurbiprofen?
If you miss a dose of Flurbiprofen, take it as soon as you remember unless it is almost time for your next dose, in which case skip the missed dose. Do not take a double dose of Flurbiprofen to make up for a missed one.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.