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Follitropin Beta: Brands, Price & Uses in Bangladesh
Follitropin Beta is a recombinant human follicle-stimulating hormone (FSH) used in the management of infertility.
About Follitropin Beta
Indications of Follitropin Beta
Follitropin Beta is a recombinant human follicle-stimulating hormone (FSH) used in the management of infertility. Its approved and evidence-supported uses include:
- Ovulation induction: In anovulatory infertile women whose infertility is functional (not due to primary ovarian failure), to stimulate follicular development and induce ovulation.
- Controlled ovarian stimulation (COS): In normally ovulatory women undergoing assisted reproductive technology (ART) procedures such as in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), used together with a subsequent human chorionic gonadotropin (hCG) trigger injection.
- Spermatogenesis induction in men: In men with primary or secondary hypogonadotropic hypogonadism, used in combination with hCG to stimulate sperm production.
Follitropin Beta is always used under the close supervision of a fertility specialist with appropriate monitoring facilities (ultrasound and hormone assays); it is not intended for self-directed use without such monitoring.
Dosage & Administration of Follitropin Beta
Dosing of Follitropin Beta must always be individualized by a fertility specialist based on ovarian/testicular response, using the lowest effective dose to minimize the risk of ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy.
| Indication | Typical Starting Dose | Adjustment |
|---|---|---|
| Ovulation induction (anovulatory women) | 50 IU subcutaneously once daily for at least 7 days | Increase by 25-50 IU at intervals of 7 days if response is inadequate, up to a usual maximum of 225-250 IU/day; hCG trigger given once adequate follicular development is confirmed |
| Controlled ovarian stimulation for IVF/ICSI | 150-225 IU subcutaneously once daily for at least 4-7 days | Adjusted according to ultrasound follicle tracking and serum estradiol; hCG trigger given when criteria for follicular maturity are met, followed by oocyte retrieval 34-36 hours later |
| Spermatogenesis induction (male hypogonadotropic hypogonadism) | hCG pretreatment alone for several months first; then Follitropin Beta 150-225 IU 2-3 times weekly with continued hCG | Continued for a minimum of 3-4 months; response (sperm production) may take up to 12 months to appear |
See Duration of Treatment and Use in Special Populations for further detail. All treatment cycles require monitoring with transvaginal ultrasound and serum estradiol (women) or serum testosterone and semen analysis (men).
Side Effects of Follitropin Beta
The most common side effects reported with Follitropin Beta include:
- Headache
- Pelvic or lower abdominal pain/discomfort
- Ovarian cysts
- Nausea
- Injection site reactions (redness, pain, bruising)
- Fatigue
- In men: acne, injection site pain, gynecomastia
A more serious but less common risk is ovarian hyperstimulation syndrome (OHSS) — see Precautions and Warnings for full detail. Uncommon effects include hypersensitivity reactions (including anaphylaxis) and thromboembolic events.
Contraindications of Follitropin Beta
Follitropin Beta is contraindicated in:
- Known hypersensitivity to follitropin beta, other gonadotropins, or any excipient in the formulation.
- Tumors of the ovary, breast, uterus, testis, hypothalamus, or pituitary gland.
- Primary ovarian failure (high FSH levels indicating gonadal failure) or primary testicular failure.
- Undiagnosed (heavy or irregular) vaginal bleeding of unknown cause.
- Ovarian cysts or ovarian enlargement not due to polycystic ovary syndrome (PCOS).
- Pregnancy.
Frequently Asked Questions about Follitropin Beta
What is Follitropin Beta used for?
Follitropin Beta is a fertility hormone injection used to stimulate egg development in women undergoing ovulation induction or IVF/ICSI treatment, and to stimulate sperm production in men with hypogonadotropic hypogonadism (a hormonal cause of infertility).
How is Follitropin Beta given?
Follitropin Beta is given as a subcutaneous injection, usually once daily during a treatment cycle, under the guidance of a fertility specialist who monitors response with ultrasound scans and blood hormone tests, adjusting the dose as needed.
What is the most serious risk with Follitropin Beta treatment?
The most serious risk is ovarian hyperstimulation syndrome (OHSS), a potentially life-threatening reaction in which the ovaries become swollen and fluid leaks into the abdomen or chest. Warning signs include severe pelvic pain, nausea, vomiting, and rapid weight gain. Anyone experiencing these symptoms while using Follitropin Beta should contact their doctor immediately or seek emergency care.
Does Follitropin Beta increase the chance of twins?
Yes. Like other fertility hormone injections, Follitropin Beta increases the chance of a multiple pregnancy (twins or more), which carries higher risks for both mother and babies. Your fertility specialist will monitor follicle development closely to try to reduce this risk.
Can Follitropin Beta be used during pregnancy or breastfeeding?
No. Follitropin Beta is contraindicated once pregnancy is confirmed, since its purpose is to help achieve pregnancy, not to be continued during it. It is not known whether it passes into breast milk, so breastfeeding women should consult their physician before use.
Who should not use Follitropin Beta?
Follitropin Beta should not be used by anyone with a known allergy to it, tumors of the ovary, breast, uterus, testis, pituitary, or hypothalamus, primary ovarian or testicular failure, undiagnosed vaginal bleeding, ovarian cysts or enlargement unrelated to PCOS, or in anyone who is already pregnant.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.