Fosfomycin Trometamol: Brands, Price & Uses in Bangladesh

Fosfomycin Trometamol is indicated for the following use:

• Uncomplicated urinary tract infection (acute cystitis) in women: Fosfomycin Trometamol is FDA-approved as a single-dose oral treatment for acute cystitis caused by susceptible strains of Escherichia coli and Enterococcus faecalis in female patients 12 years of age and older. This is an established, guideline-supported indication.

Not indicated for: Fosfomycin Trometamol is not indicated for the treatment of pyelonephritis, perinephric abscess, or complicated urinary tract infections, as adequate drug levels for these conditions have not been established. It is also not approved for use in men, as efficacy in this population has not been demonstrated.

Use of Fosfomycin Trometamol outside of these established indications (e.g., for other Gram-negative or Gram-positive infections) is considered off-label and is not routinely recommended without specific susceptibility data and specialist guidance.

Adult Dose (Female patients 12 years and older)

Administration Instructions

• Pour the entire contents of one sachet into a glass of cool water and stir well to dissolve; do not use hot water. Take immediately after dissolving; do not store the reconstituted solution for later use.
• May be taken with or without food, though taking it on an empty stomach or shortly before a meal, preferably in the evening after emptying the bladder, is often recommended to help optimize urinary concentrations.
• Do not take a second dose to treat the same episode of infection unless specifically directed by a physician, as repeat dosing does not improve efficacy in uncomplicated cystitis and is not part of the approved regimen.

Antibiotic Stewardship

Take Fosfomycin Trometamol exactly as prescribed by your physician; do not stop, extend, skip doses, or share this medicine with others without medical advice. Even though Fosfomycin Trometamol is given as a single dose, completing the full prescribed course and following the physician's instructions helps ensure effective treatment and reduces the risk of antibiotic resistance.

Most adverse effects associated with Fosfomycin Trometamol are mild and self-limited following the single-dose regimen.

Common

• Diarrhea
• Nausea
• Headache
• Vaginitis
• Dizziness
• Abdominal pain or dyspepsia

Less Common / Rare

• Rash or pruritus
• Asthenia (weakness)
• Rare reports of severe diarrhea associated with Clostridioides difficile (antibiotic-associated colitis), which can range from mild to life-threatening and may occur up to several weeks after treatment
• Rare hypersensitivity reactions, including angioedema