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G-Heparin25000 IU/5
Gonoshasthaya Pharmaceuticals Limited
৳261.25
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Generic medicine
Heparin Sodium: Brands, Price & Uses in Bangladesh
Heparin Sodium is an injectable anticoagulant with the following established uses: FDA-Approved / Established Indications Prophylaxis and treatment of venous thrombosis and pulmonary embolism…
About Heparin Sodium
Indications of Heparin Sodium
Heparin Sodium is an injectable anticoagulant with the following established uses:
FDA-Approved / Established Indications
- Prophylaxis and treatment of venous thrombosis and pulmonary embolism
- Prevention of postoperative deep vein thrombosis in patients undergoing major abdominal, thoracic, or other surgery
- Atrial fibrillation with embolization
- Diagnosis and treatment of acute and chronic disseminated intravascular coagulation (DIC), under specialist supervision
- Anticoagulation in arterial and cardiac surgery (e.g., cardiopulmonary bypass)
- Maintaining patency of intravenous indwelling catheters and central lines (low-dose flush use)
- Anticoagulation during blood transfusion, extracorporeal circulation, and dialysis procedures
Guideline-Supported / Adjunct Uses
- Bridging anticoagulation in patients transitioning to or from oral anticoagulants (e.g., peri-procedurally)
- Acute coronary syndromes, as an adjunct to other therapies per cardiology guidelines
Use of Heparin Sodium should always be guided by a physician based on individual risk factors, coagulation status, and monitoring capability.
Dosage & Administration of Heparin Sodium
General Principles
Dosage of Heparin Sodium must be individualized and is usually monitored using activated partial thromboplastin time (aPTT) for therapeutic (full-dose) regimens. Low-dose prophylactic regimens generally do not require routine aPTT monitoring.
| Indication | Typical Adult Dosage |
|---|---|
| Deep vein thrombosis / pulmonary embolism (therapeutic) | Initial IV bolus of 5,000 units, followed by continuous IV infusion of 20,000-40,000 units/24 hours, adjusted to maintain target aPTT; alternatively, intermittent IV or deep subcutaneous dosing per protocol |
| Postoperative DVT prophylaxis (low-dose) | 5,000 units subcutaneously 2 hours before surgery, then every 8-12 hours during the period of risk |
| Cardiovascular / cardiopulmonary bypass surgery | 150-400 units/kg IV depending on procedure duration, per institutional protocol |
| Line/catheter patency (flush) | Low-dose heparin flush solution as per catheter manufacturer/hospital protocol |
Pediatric Dosage
Loading dose of approximately 75-100 units/kg IV bolus, followed by a maintenance infusion of about 18-30 units/kg/hour, adjusted to maintain target aPTT; dosing must be individualized under specialist supervision, and only preservative-free Heparin Sodium should be used in neonates and infants.
Renal/Hepatic Impairment
No formal dose-adjustment protocol is established; however, clearance may be reduced in significant hepatic or renal impairment, so more frequent coagulation monitoring and cautious dose titration are recommended.
See Precautions and Warnings for essential monitoring requirements and the boxed warning on medication errors related to varying vial concentrations.
Side Effects of Heparin Sodium
Common and serious adverse effects associated with Heparin Sodium include:
- Bleeding/hemorrhage: The most common risk, ranging from minor bruising to major hemorrhage (e.g., gastrointestinal, retroperitoneal, adrenal).
- Heparin-induced thrombocytopenia (HIT): An immune-mediated drop in platelet count that can paradoxically cause new arterial or venous thrombosis; see Precautions and Warnings.
- Injection-site reactions: Pain, irritation, bruising, or, rarely, skin necrosis at the injection site.
- Hypersensitivity reactions: Chills, fever, urticaria, and rarely anaphylaxis.
- Elevated liver transaminases: Usually transient and reversible.
- Osteoporosis: Associated with prolonged high-dose use.
- Hyperkalemia: Due to suppression of aldosterone secretion, particularly with prolonged use.
Report any unusual bleeding, bruising, or signs of allergic reaction to a physician immediately.
Contraindications of Heparin Sodium
Heparin Sodium is contraindicated in:
- Known hypersensitivity to heparin or pork products (for porcine-derived heparin)
- History of heparin-induced thrombocytopenia (HIT) or heparin-induced thrombocytopenia with thrombosis (HITTS)
- Severe thrombocytopenia
- Uncontrolled active major bleeding, except in specific, specialist-managed contexts such as some cases of disseminated intravascular coagulation
- Inability to obtain required coagulation tests at appropriate intervals (for full-dose therapy)
Frequently Asked Questions about Heparin Sodium
What is Heparin Sodium used for?
Heparin Sodium is an injectable anticoagulant used to prevent and treat blood clots (deep vein thrombosis and pulmonary embolism), to prevent clots after surgery, during heart and blood vessel surgery, dialysis, and to keep intravenous catheters open.
How is Heparin Sodium given?
Heparin Sodium is given only by injection - either into a vein (intravenous) or under the skin (subcutaneous) - by a trained healthcare professional; it is never taken by mouth and never given into a muscle.
What is the most serious risk with Heparin Sodium?
The most serious risk is heparin-induced thrombocytopenia (HIT), a reaction in which platelet counts drop and, paradoxically, new blood clots can form, sometimes becoming life-threatening. Regular blood tests to monitor platelet counts are required during treatment, especially in the first two weeks, and Heparin Sodium must be stopped immediately if HIT is suspected.
Can Heparin Sodium be used during pregnancy?
Heparin Sodium does not cross the placenta and is often the preferred anticoagulant during pregnancy when one is needed, but it should be used only if clearly necessary and under close medical supervision, weighing the benefits against any potential risks.
What if too much Heparin Sodium is given or bleeding occurs?
An overdose of Heparin Sodium can cause bleeding ranging from minor to severe. Seek immediate medical attention or contact emergency services if this is suspected. A specific antidote, protamine sulfate, can reverse its effect and is given only by medical staff in a clinical setting.
Why do vial strengths of Heparin Sodium matter so much?
Heparin Sodium is available in several different concentrations that can look similar. Serious, sometimes fatal, dosing errors have happened when the wrong strength was used, so healthcare staff always carefully double-check the concentration and dose before giving Heparin Sodium.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.