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Human Menopausal Gonadotrophin: Brands, Price & Uses in Bangladesh
Human Menopausal Gonadotrophin is a purified preparation of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity, extracted from the urine of postmenopausal women and more.
About Human Menopausal Gonadotrophin
Indications of Human Menopausal Gonadotrophin
Human Menopausal Gonadotrophin is a purified preparation of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity, extracted from the urine of postmenopausal women, used in the management of infertility. Its approved and evidence-supported uses include:
- Ovulation induction: In anovulatory infertile women (including those who have not responded adequately to clomiphene citrate), to stimulate follicular development and induce ovulation, typically combined with a subsequent human chorionic gonadotropin (hCG) trigger.
- Controlled ovarian stimulation (COS) for assisted reproductive technology (ART): In women undergoing in vitro fertilization (IVF) or related procedures, to promote development of multiple follicles ahead of oocyte retrieval, used together with hCG.
- Spermatogenesis induction in men: In men with hypogonadotropic hypogonadism, used in combination with hCG (given first to restore intratesticular testosterone) to stimulate sperm production.
Human Menopausal Gonadotrophin is used only under the close supervision of a fertility specialist or reproductive endocrinologist with access to ultrasound and hormone-monitoring facilities; it is not intended for self-directed use.
Dosage & Administration of Human Menopausal Gonadotrophin
Dosing of Human Menopausal Gonadotrophin must always be individualized by a fertility specialist based on ovarian or testicular response, using the lowest effective dose to minimize the risk of ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy.
| Indication | Typical Starting Dose | Adjustment |
|---|---|---|
| Ovulation induction (anovulatory women) | 75-150 IU intramuscularly or subcutaneously once daily, starting early in the cycle | Adjusted at intervals of several days according to ultrasound follicle tracking and serum estradiol; hCG trigger given once adequate follicular development is confirmed |
| Controlled ovarian stimulation for IVF/ART | 150-225 IU once daily, started early in the treatment cycle, often with a GnRH agonist/antagonist protocol | Adjusted according to ovarian response; hCG trigger given when follicular maturity criteria are met, followed by oocyte retrieval 34-36 hours later |
| Spermatogenesis induction (male hypogonadotropic hypogonadism) | hCG pretreatment alone for several months first; then Human Menopausal Gonadotrophin 75-150 IU 2-3 times weekly with continued hCG | Continued for a minimum of 3-4 months; a measurable response in sperm count may take up to 12 months or longer to appear |
See Duration of Treatment and Use in Special Populations for further detail. All treatment cycles require monitoring with transvaginal ultrasound and serum estradiol (women) or serum testosterone and semen analysis (men).
Side Effects of Human Menopausal Gonadotrophin
The most common side effects reported with Human Menopausal Gonadotrophin include:
- Headache
- Pelvic or lower abdominal pain/discomfort
- Ovarian enlargement or ovarian cysts
- Nausea and abdominal bloating
- Injection site reactions (redness, pain, bruising)
- Breast tenderness
- In men: gynecomastia, acne, injection site pain
A more serious but less common risk is ovarian hyperstimulation syndrome (OHSS) — see Precautions and Warnings for full detail. Uncommon effects include hypersensitivity reactions (including anaphylaxis) and thromboembolic events.
Contraindications of Human Menopausal Gonadotrophin
Human Menopausal Gonadotrophin is contraindicated in:
- Known hypersensitivity to human menopausal gonadotropin, other gonadotropins, or any excipient in the formulation.
- Tumors of the ovary, breast, uterus, testis, hypothalamus, or pituitary gland.
- Primary ovarian failure or primary testicular failure.
- Undiagnosed (abnormal or heavy) vaginal bleeding of unknown cause.
- Ovarian cysts or ovarian enlargement not due to polycystic ovary syndrome (PCOS).
- Pregnancy.
Frequently Asked Questions about Human Menopausal Gonadotrophin
What is Human Menopausal Gonadotrophin used for?
Human Menopausal Gonadotrophin is a fertility hormone injection, purified from the urine of postmenopausal women, used to stimulate egg development in women undergoing ovulation induction or assisted reproductive technology (such as IVF), and to stimulate sperm production in men with hypogonadotropic hypogonadism (a hormonal cause of infertility).
How is Human Menopausal Gonadotrophin given?
Human Menopausal Gonadotrophin is supplied as a powder that must be reconstituted with the provided solvent immediately before each injection, and is then given by intramuscular or subcutaneous injection, usually once daily during a treatment cycle, under the guidance of a fertility specialist who monitors response with ultrasound scans and blood hormone tests, adjusting the dose as needed.
What is the most serious risk with Human Menopausal Gonadotrophin treatment?
The most serious risk is ovarian hyperstimulation syndrome (OHSS), a potentially life-threatening reaction in which the ovaries become swollen and fluid leaks into the abdomen or chest. Warning signs include severe pelvic pain, nausea, vomiting, and rapid weight gain. Anyone experiencing these symptoms while using Human Menopausal Gonadotrophin should contact their doctor immediately or seek emergency care.
Does Human Menopausal Gonadotrophin increase the chance of twins?
Yes. Like other fertility hormone injections, Human Menopausal Gonadotrophin increases the chance of a multiple pregnancy (twins or more), and this risk has historically been somewhat higher with this type of urinary gonadotropin regimen, which carries higher risks for both mother and babies. Your fertility specialist will monitor follicle development closely with ultrasound and hormone testing to try to reduce this risk.
Can Human Menopausal Gonadotrophin be used during pregnancy or breastfeeding?
No. Human Menopausal Gonadotrophin is contraindicated once pregnancy is confirmed, since its purpose is to help achieve pregnancy, not to be continued during it. It is not known whether it passes into breast milk, so breastfeeding women should consult their physician before use.
Who should not use Human Menopausal Gonadotrophin?
Human Menopausal Gonadotrophin should not be used by anyone with a known allergy to it, tumors of the ovary, breast, uterus, testis, pituitary, or hypothalamus, primary ovarian or testicular failure, undiagnosed vaginal bleeding, ovarian cysts or enlargement unrelated to PCOS, or in anyone who is already pregnant.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.