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Human Papillomavirus Quadrivalent: Brands, Price & Uses in Bangladesh
Human Papillomavirus Quadrivalent is a non-infectious, recombinant vaccine indicated for the prevention of disease caused by human papillomavirus (HPV) types 6, 11, 16, and 18 and more.
About Human Papillomavirus Quadrivalent
Indications of Human Papillomavirus Quadrivalent
Human Papillomavirus Quadrivalent is a non-infectious, recombinant vaccine indicated for the prevention of disease caused by human papillomavirus (HPV) types 6, 11, 16, and 18, in the approved age range per national and manufacturer guidance (typically 9 through 45 years, per product labeling and WHO/CDC guidance).
Established / approved uses (girls and women)
- Prevention of cervical cancer and cervical intraepithelial neoplasia (CIN grades 1-3) caused by HPV types 16 and 18.
- Prevention of vulvar and vaginal cancer and related intraepithelial neoplasia (VIN, VaIN) caused by HPV types 16 and 18.
- Prevention of anal cancer and anal intraepithelial neoplasia (AIN) caused by HPV types 16 and 18.
- Prevention of genital warts (condyloma acuminata) caused by HPV types 6 and 11.
Established / approved uses (boys and men)
- Prevention of anal cancer and anal intraepithelial neoplasia caused by HPV types 16 and 18.
- Prevention of genital warts caused by HPV types 6 and 11.
Guideline-supported use
- National immunization programs and WHO guidance support routine vaccination with Human Papillomavirus Quadrivalent for adolescents (typically age 9-14 years) as primary cervical cancer and HPV-disease prevention, and catch-up vaccination up to age 26 (and, per individualized clinical decision, up to age 45) where locally approved.
Human Papillomavirus Quadrivalent does not treat existing HPV infection, genital warts, or cervical dysplasia, and does not eliminate the need for women to continue recommended cervical cancer screening.
Dosage & Administration of Human Papillomavirus Quadrivalent
Human Papillomavirus Quadrivalent is given as a series of intramuscular injections; the number of doses depends on the age at the first dose, per current national/WHO immunization schedules.
| Age at first dose | Schedule | Total doses |
|---|---|---|
| 9 through 14 years | 0 and 6-12 months (2-dose schedule, per updated WHO/CDC guidance) | 2 doses |
| 15 through 45 years, or immunocompromised individuals of any eligible age | 0, 2, and 6 months (3-dose schedule) | 3 doses |
Each dose of Human Papillomavirus Quadrivalent is 0.5 mL, given by intramuscular injection, preferably in the deltoid region of the upper arm or the higher anterolateral area of the thigh. If a dose of Human Papillomavirus Quadrivalent is delayed, the series does not need to be restarted; the next dose in the sequence should be given as soon as possible.
Side Effects of Human Papillomavirus Quadrivalent
Side effects reported with Human Papillomavirus Quadrivalent are usually mild and self-limited.
Very common / common
- Injection-site reactions: pain, swelling, redness (erythema), itching, bruising.
- Headache
- Fever
- Nausea
- Dizziness
Uncommon / rare but important
- Syncope (fainting), sometimes with brief seizure-like activity, shortly after injection of Human Papillomavirus Quadrivalent (see Precautions).
- Hypersensitivity reactions, including anaphylaxis.
- Postmarketing reports of Guillain-Barré syndrome, venous thromboembolism, and autoimmune conditions have been described temporally after receipt of Human Papillomavirus Quadrivalent, without an established causal relationship.
Contraindications of Human Papillomavirus Quadrivalent
Human Papillomavirus Quadrivalent is contraindicated in individuals with:
- Known severe hypersensitivity (e.g., anaphylaxis) to any component of Human Papillomavirus Quadrivalent, including yeast.
- A severe allergic reaction after a previous dose of Human Papillomavirus Quadrivalent.
Frequently Asked Questions about Human Papillomavirus Quadrivalent
What is Human Papillomavirus Quadrivalent used for?
Human Papillomavirus Quadrivalent is a vaccine used to prevent infection with human papillomavirus (HPV) types 6, 11, 16, and 18, and the diseases these types cause, including cervical, vulvar, vaginal, and anal cancers and precancerous lesions, as well as genital warts. Human Papillomavirus Quadrivalent works best when given before any exposure to HPV occurs.
At what age should Human Papillomavirus Quadrivalent be given?
Human Papillomavirus Quadrivalent is approved from 9 through 45 years of age, but it is most effective when given to adolescents (typically age 9-14 years) before the start of sexual activity. Those who start the series at 9-14 years of age receive 2 doses of Human Papillomavirus Quadrivalent, while those who start at 15 years or older, or who are immunocompromised, receive 3 doses.
Is Human Papillomavirus Quadrivalent safe during pregnancy?
Human Papillomavirus Quadrivalent is not recommended during pregnancy and should be deferred until after the pregnancy is completed. If a dose of Human Papillomavirus Quadrivalent is inadvertently given during pregnancy, this should be discussed with a physician; available data have not shown clear evidence of fetal harm, but Human Papillomavirus Quadrivalent should still only be used in pregnancy if clearly needed and after medical advice.
What are the common side effects of Human Papillomavirus Quadrivalent?
The most common side effects of Human Papillomavirus Quadrivalent are injection-site pain, swelling and redness, headache, fever, nausea, and dizziness. Fainting (syncope) can occur shortly after injection, which is why observation for about 15 minutes after each dose of Human Papillomavirus Quadrivalent is recommended.
Does Human Papillomavirus Quadrivalent treat an existing HPV infection or genital warts?
No. Human Papillomavirus Quadrivalent is a preventive vaccine only; it does not treat existing HPV infection, genital warts, or cervical/vulvar/vaginal/anal dysplasia that is already present. Women who receive Human Papillomavirus Quadrivalent should continue routine cervical cancer screening as advised by their physician.
Can Human Papillomavirus Quadrivalent be given with other vaccines?
Human Papillomavirus Quadrivalent can generally be given at the same visit as other age-appropriate vaccines, using separate syringes and separate injection sites. Human Papillomavirus Quadrivalent should not be mixed with any other vaccine in the same syringe.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.