Hydrochlorothiazide + Triamterene: Brands, Price & Uses in Bangladesh

Approved Indications

Hydrochlorothiazide + Triamterene is a fixed-dose combination of a thiazide diuretic (hydrochlorothiazide) and a potassium-sparing diuretic (triamterene). It is FDA-approved for use in patients for whom this specific combination is considered appropriate, generally including:

• Hypertension — for the treatment of high blood pressure, either alone or as an add-on when a single diuretic is insufficient or when a patient has developed or is at risk of hypokalemia on hydrochlorothiazide alone.
• Edema — for edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, and corticosteroid- or estrogen-induced fluid retention, particularly when maintenance of normal serum potassium is desirable.

Hydrochlorothiazide + Triamterene is intended for patients in whom the combination of a kaliuretic (potassium-wasting) and a potassium-conserving diuretic is felt to be a clinically appropriate strategy — it is not first-line therapy for every patient with hypertension or edema, and the decision to use it should follow evaluation of individual electrolyte and renal status.

Dosing by Indication

Pediatric Dosing

Safety and effective dosing of Hydrochlorothiazide + Triamterene have not been established in children; it is generally not recommended for pediatric use (see Use in Special Populations).

Renal Impairment

Hydrochlorothiazide + Triamterene is contraindicated in patients with anuria or significant renal impairment because both components depend on adequate renal function and the risk of dangerous hyperkalemia rises sharply (see Contraindications).

Hepatic Impairment

Use with caution in hepatic impairment; diuretic-induced electrolyte and fluid shifts can precipitate hepatic encephalopathy in patients with liver disease.

General Administration Notes

Take exactly as directed by the prescribing physician. Do not increase, decrease, stop, or restart doses without medical advice, and attend scheduled blood tests to monitor kidney function and electrolytes.

Common Side Effects

• Dizziness, headache, and fatigue
• Nausea, vomiting, or gastrointestinal upset
• Muscle cramps or weakness
• Dry mouth or increased thirst
• Increased urination

Serious / Less Common Side Effects

• Hyperkalemia (elevated blood potassium) — see Precautions and Warnings
• Hyponatremia (low blood sodium) with confusion, lethargy, or seizures in severe cases
• Kidney stones and, rarely, acute interstitial nephritis related to triamterene
• Photosensitivity (increased skin sensitivity to sunlight)
• Hyperuricemia, which may precipitate a gout attack
• Hyperglycemia, particularly in patients with diabetes or prediabetes
• Blood disorders such as leukopenia or thrombocytopenia (rare)
• Hypersensitivity reactions, including rash or, rarely, severe skin reactions