Isradipine: Brands, Price & Uses in Bangladesh

Isradipine is indicated for the treatment of hypertension (high blood pressure). It may be used alone or in combination with other antihypertensive agents, most commonly a thiazide diuretic, when a single agent does not adequately control blood pressure.

• Established/FDA-approved use: Management of essential hypertension, as monotherapy or as part of combination antihypertensive therapy.
• Combination therapy: Isradipine has been studied and used together with thiazide-type diuretics for an additive antihypertensive effect in patients not controlled on a single agent.

Isradipine is not approved for the treatment of acute hypertensive emergencies or angina.

Adult Dosage - Hypertension

Special Situations

• Hepatic impairment: Isradipine undergoes extensive hepatic metabolism; lower starting doses and slower titration are recommended, with close monitoring of blood pressure.
• Renal impairment: No specific dosage adjustment is generally required, but blood pressure response should be monitored.
• Elderly patients: Response to Isradipine may be greater in older patients; a conservative starting dose with careful titration is advised.

Isradipine should be taken consistently, either with or without food, as directed by the physician, and should not be discontinued abruptly without medical advice.

Common side effects of Isradipine are generally related to its vasodilatory action and are often dose-dependent:

• Peripheral edema (swelling of the ankles/feet)
• Headache
• Dizziness or lightheadedness
• Flushing
• Palpitations and reflex tachycardia
• Fatigue

Less commonly, Isradipine may cause symptomatic hypotension, and rarely, worsening of angina symptoms may occur at the start of therapy or with dose increases (see Precautions and Warnings). Patients should report persistent or severe side effects to their physician.