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Levamlodipine Maleate: Brands, Price & Uses in Bangladesh
Levamlodipine Maleate is indicated for the treatment of hypertension (high blood pressure), to lower blood pressure.
About Levamlodipine Maleate
Indications of Levamlodipine Maleate
Levamlodipine Maleate is indicated for the treatment of hypertension (high blood pressure), to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
- Established use: Hypertension in adults, used alone or in combination with other classes of antihypertensive agents (e.g., ACE inhibitors, angiotensin receptor blockers, diuretics, beta-blockers).
- Established use (pediatric): Hypertension in children and adolescents 6 to 17 years of age.
Levamlodipine Maleate contains the pharmacologically active S-enantiomer of amlodipine, allowing effective blood pressure control at approximately half the milligram dose of racemic amlodipine.
Dosage & Administration of Levamlodipine Maleate
Adults — Hypertension
| Population | Recommended Dose |
|---|---|
| Usual adults | Initial: 2.5 mg orally once daily; may be increased to a maximum of 5 mg once daily based on blood pressure response |
| Small, fragile, elderly patients or those with hepatic insufficiency | Initial: 1.25 mg orally once daily |
Dose titration should generally occur over 7–14 days, based on individual response, unless more rapid titration is clinically indicated.
Pediatric Patients (6–17 years) — Hypertension
Initial dose: 1.25 mg to 2.5 mg orally once daily. Doses above 2.5 mg daily have not been studied in pediatric patients. Safety and efficacy in children under 6 years have not been established (see Use in Special Populations).
Hepatic Impairment
Specific dosage adjustment studies have not been conducted, but because Levamlodipine Maleate is extensively metabolized by the liver and its half-life is prolonged with hepatic impairment, start at 1.25 mg once daily and titrate slowly with close monitoring.
Renal Impairment
No dosage adjustment is required, as Levamlodipine Maleate pharmacokinetics are not significantly influenced by renal impairment.
Side Effects of Levamlodipine Maleate
Adverse effects of Levamlodipine Maleate are generally dose-related.
Common (≥1%)
- Peripheral edema (dose-dependent; more common in females)
- Flushing
- Palpitations
- Dizziness
- Headache
- Fatigue
- Nausea and abdominal discomfort
- Somnolence
Less Common / Postmarketing
- Jaundice and hepatic enzyme elevations
- Gynecomastia
- Extrapyramidal disorder (rare)
- Worsening angina or myocardial infarction, particularly on initiation or dose increase in patients with severe obstructive coronary artery disease (see Precautions and Warnings)
Contraindications of Levamlodipine Maleate
Levamlodipine Maleate is contraindicated in patients with known hypersensitivity to levamlodipine, amlodipine, or other dihydropyridine calcium channel blockers.
Frequently Asked Questions about Levamlodipine Maleate
What is Levamlodipine Maleate used for?
Levamlodipine Maleate is used to treat high blood pressure (hypertension) in adults and children 6 years and older. It helps lower blood pressure, which reduces the risk of stroke and heart attack.
How should I take Levamlodipine Maleate?
Take Levamlodipine Maleate exactly as prescribed, once daily, with or without food, at the same time each day. Do not stop taking it suddenly without talking to your doctor, especially if you have heart disease.
What are the common side effects of Levamlodipine Maleate?
The most common side effects are swelling of the ankles or feet, flushing, palpitations, dizziness, headache, and tiredness. These effects tend to be dose-related. Contact your doctor if swelling or other side effects are bothersome or severe.
Can I take Levamlodipine Maleate during pregnancy or while breastfeeding?
Data on Levamlodipine Maleate use in pregnancy are limited, so it should be used only if your doctor decides the benefit clearly outweighs the potential risk to the baby. Small amounts pass into breast milk; discuss breastfeeding plans with your physician, who will weigh the benefits and risks for you and your infant.
Who should not take Levamlodipine Maleate?
Levamlodipine Maleate should not be used by anyone with a known allergy (hypersensitivity) to levamlodipine, amlodipine, or other dihydropyridine calcium channel blockers.
What should I do if I take too much Levamlodipine Maleate?
An overdose of Levamlodipine Maleate can cause dangerously low blood pressure and a fast heart rate. If an overdose is suspected, seek immediate medical attention or contact emergency services or a poison control center right away; do not try to manage it at home.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.