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Midolam5 mg/ml
Opsonin Pharma Ltd.
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Generic medicine
Midazolam: Brands, Price & Uses in Bangladesh
Midazolam is a short-acting benzodiazepine used mainly in hospital and clinical settings, under the supervision of trained healthcare professionals.
About Midazolam
Indications of Midazolam
Midazolam is a short-acting benzodiazepine used mainly in hospital and clinical settings, under the supervision of trained healthcare professionals.
Established / FDA-approved uses
- Sedation, anxiolysis, and amnesia before or during diagnostic or therapeutic procedures (e.g. endoscopy, bronchoscopy, cardiac catheterization)
- Premedication and induction of general anesthesia, and as a component of balanced anesthesia
- Continuous sedation of intubated, mechanically ventilated patients in intensive care
Guideline-supported use
- First-line treatment of acute seizures and status epilepticus, particularly by the intramuscular, buccal, or intranasal route when intravenous access is not immediately available
Other approved use (market-specific, short-term only)
- Short-term treatment of severe insomnia (oral tablet, in markets where this indication is approved), limited to a few days due to the risk of tolerance and dependence
All uses of Midazolam require administration or prescribing by a qualified healthcare professional; it is not intended for unsupervised self-medication.
Dosage & Administration of Midazolam
Dosing of Midazolam must always be individualized by a healthcare professional according to indication, age, body weight, renal/hepatic function, and concomitant medications. Doses below are general references and do not replace clinical judgment.
| Indication | Typical adult dose | Notes |
|---|---|---|
| Procedural sedation (IV) | Initial 1-2.5 mg slow IV over at least 2 minutes; titrate to effect | Reduce dose in elderly/debilitated patients and when opioids are co-administered |
| Preoperative sedation (IM) | Approximately 0.07-0.1 mg/kg, 30-60 minutes before surgery | Administered by trained personnel |
| Induction of anesthesia (IV) | Individualized; per anesthesiologist's protocol | Given only by anesthesia providers |
| Continuous ICU sedation (IV infusion) | Individualized infusion rate, titrated to sedation goal | Requires continuous monitoring |
| Status epilepticus / acute seizures | Per emergency protocol (IM, buccal, or intranasal) | Given as first-line therapy when IV access is unavailable |
| Short-term insomnia (oral, where approved) | 7.5-15 mg at bedtime; elderly 7.5 mg | Limit to a few days; not for routine long-term use |
Pediatric dosing
Weight-based and route-specific; generally higher mg/kg doses are needed in younger children. Always calculated and administered by a clinician experienced in pediatric sedation.
Renal/hepatic adjustment
Dose reduction and closer monitoring are required in hepatic or renal impairment, as both prolong the sedative and respiratory-depressant effects of Midazolam (see Use in Special Populations).
Side Effects of Midazolam
Adverse effects of Midazolam vary by route and dose. The most serious risk, respiratory depression and apnea (see Precautions and Warnings), is more common with intravenous administration, higher doses, or concomitant CNS depressants.
Common
- Drowsiness, sedation, and fatigue
- Headache
- Hiccups, nausea, or vomiting
- Injection-site pain or local reaction
- Amnesia (anterograde memory loss), which is often an intended effect for procedural sedation
Less common / serious
- Decreased respiratory rate, hypoxia, apnea
- Hypotension, bradycardia
- Paradoxical reactions: agitation, involuntary movements, combativeness (more frequent in children and the elderly)
- Laryngospasm or bronchospasm
- Allergic reactions
Contraindications of Midazolam
Midazolam is contraindicated in:
- Known hypersensitivity to Midazolam or other benzodiazepines
- Acute narrow-angle glaucoma
- Concomitant use with potent CYP3A4 inhibitors for oral Midazolam formulations (see Interactions), due to risk of prolonged sedation and respiratory depression
Frequently Asked Questions about Midazolam
What is Midazolam used for?
Midazolam is a short-acting benzodiazepine used mainly in hospital and clinical settings for sedation before procedures or surgery, as part of anesthesia induction, for continuous sedation in intensive care, and for emergency treatment of acute seizures or status epilepticus. It is given or prescribed by a healthcare professional, not for self-directed use.
Is Midazolam safe to use during pregnancy?
Midazolam should be avoided during pregnancy unless there is no safer alternative and the potential benefit clearly outweighs the potential risk to the baby, since it crosses the placenta and benzodiazepines have been linked to risks including neonatal respiratory depression and withdrawal near delivery. Always consult your physician before use in pregnancy.
Can Midazolam be used while breastfeeding?
Midazolam passes into breast milk. Breastfeeding is generally not advised for a period after receiving Midazolam; ask your physician how long to wait before resuming breastfeeding after a dose.
What are the main risks of Midazolam?
The most serious risk of Midazolam is severe, potentially life-threatening slowing or stopping of breathing (respiratory depression), particularly when combined with opioids, alcohol, or other sedating medicines, or when given without proper monitoring. For this reason Midazolam is normally given only by trained healthcare staff with monitoring and resuscitation equipment available.
Can I take Midazolam with other medicines?
Combining Midazolam with opioids, other sedatives, alcohol, or certain antifungal or antiviral medicines (strong CYP3A4 inhibitors) can dangerously increase sedation and the risk of breathing problems, or alter how much Midazolam is in your body. Always tell your doctor about all medicines, supplements, and herbal products you take before receiving Midazolam.
What should I do if too much Midazolam is given or taken?
An overdose of Midazolam can cause extreme drowsiness, confusion, slowed or stopped breathing, and coma. This is a medical emergency — seek immediate medical attention or contact emergency services right away. Do not try to manage a suspected overdose at home.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.