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Terazon2 mg
Incepta Pharmaceuticals Ltd.
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Generic medicine
Terazosin Hydrochloride: Brands, Price & Uses in Bangladesh
Terazosin Hydrochloride is a selective alpha-1 adrenergic receptor antagonist approved for two main indications: Benign prostatic hyperplasia (BPH): Established and more.
About Terazosin Hydrochloride
Indications of Terazosin Hydrochloride
Terazosin Hydrochloride is a selective alpha-1 adrenergic receptor antagonist approved for two main indications:
- Benign prostatic hyperplasia (BPH): Established, FDA-approved use for the treatment of signs and symptoms of BPH, including urinary hesitancy, weak stream, incomplete emptying, and nocturia. Terazosin Hydrochloride relaxes smooth muscle in the bladder neck and prostate, improving urine flow. It provides symptomatic relief only and does not reduce prostate size or halt disease progression.
- Hypertension: Established, FDA-approved use for the treatment of essential hypertension, either as monotherapy or in combination with other antihypertensive agents (e.g., diuretics, beta-blockers).
Terazosin Hydrochloride is not indicated for use in women or children, and it does not treat prostate cancer.
Dosage & Administration of Terazosin Hydrochloride
Benign Prostatic Hyperplasia (BPH)
| Step | Dose |
|---|---|
| Initial | 1 mg once daily at bedtime |
| Titration | Increase stepwise to 2 mg, then 5 mg, then 10 mg once daily, as needed, at intervals guided by response (generally not sooner than every few days to weeks) |
| Usual maintenance | 5-10 mg once daily; most patients require 10 mg daily for optimal response |
| Trial period | An adequate trial at the maximum dose should be given for 4-6 weeks before concluding that Terazosin Hydrochloride is ineffective |
Hypertension
| Step | Dose |
|---|---|
| Initial | 1 mg once daily at bedtime, to minimize first-dose hypotension |
| Titration | Increase gradually based on blood pressure response |
| Usual maintenance | 1-5 mg once daily; some patients may require up to 20 mg daily |
| Maximum | Doses above 20 mg daily generally provide no additional benefit for hypertension; doses above 40 mg have not been evaluated |
If therapy with Terazosin Hydrochloride is interrupted for several days or longer, treatment should be restarted using the initial 1 mg dose and re-titrated.
Side Effects of Terazosin Hydrochloride
Common side effects of Terazosin Hydrochloride include:
- Dizziness
- Orthostatic (postural) hypotension
- Asthenia (weakness/fatigue)
- Somnolence (drowsiness)
- Nasal congestion
- Peripheral edema
- Headache
- Palpitations
Less common but serious effects include syncope (fainting), particularly with the first dose or after dose increases (see Precautions and Warnings), and priapism (rare, requires emergency treatment).
Contraindications of Terazosin Hydrochloride
Terazosin Hydrochloride is contraindicated in patients with known hypersensitivity to terazosin or to other quinazoline-derived alpha-1 blockers (e.g., doxazosin, prazosin), due to potential cross-sensitivity.
Frequently Asked Questions about Terazosin Hydrochloride
What is Terazosin Hydrochloride used for?
Terazosin Hydrochloride is used to treat symptoms of benign prostatic hyperplasia (BPH) such as difficulty urinating, and to treat high blood pressure (hypertension).
Why do I need to take the first dose of Terazosin Hydrochloride at bedtime?
The first dose of Terazosin Hydrochloride (and doses after an increase) can cause a sudden drop in blood pressure, dizziness, or fainting (the "first-dose effect"). Taking it at bedtime and avoiding driving or hazardous tasks for about 24 hours reduces this risk.
Can Terazosin Hydrochloride shrink my prostate?
No. Terazosin Hydrochloride relaxes muscle in the prostate and bladder neck to improve urine flow and relieve symptoms, but it does not shrink the prostate or stop BPH from progressing over time.
Is it safe to take Terazosin Hydrochloride with medicines for erectile dysfunction?
Combining Terazosin Hydrochloride with PDE5 inhibitors (such as sildenafil or tadalafil) can cause an additive drop in blood pressure. Tell your doctor about all medicines you take; your doctor may advise timing adjustments or dose caution before combining these medicines.
What should I tell my eye surgeon if I take Terazosin Hydrochloride?
If you take or have ever taken Terazosin Hydrochloride, tell your ophthalmologist before any cataract surgery, since alpha-blockers like Terazosin Hydrochloride can cause a condition called intraoperative floppy iris syndrome (IFIS) during the operation.
What should I do if I miss a dose or stop Terazosin Hydrochloride for several days?
Do not double the dose. If you stop Terazosin Hydrochloride for several days or longer, contact your doctor before restarting, as treatment usually needs to restart at the lowest 1 mg dose and be re-titrated to avoid a first-dose-like hypotensive reaction.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.