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Ulipristal Acetate [For uterine fibroids]: Brands, Price & Uses in Bangladesh
Ulipristal Acetate [For uterine fibroids] is a selective progesterone receptor modulator (SPRM) indicated in premenopausal women for the intermittent or pre-operative treatment of moderate-to-severe…
About Ulipristal Acetate [For uterine fibroids]
Indications of Ulipristal Acetate [For uterine fibroids]
Ulipristal Acetate [For uterine fibroids] is a selective progesterone receptor modulator (SPRM) indicated in premenopausal women for the intermittent or pre-operative treatment of moderate-to-severe signs and symptoms of uterine fibroids (leiomyomas), such as heavy or prolonged menstrual bleeding, pelvic pain/pressure, and fibroid-related anemia.
- Guideline-supported/established use: Pre-operative treatment to reduce fibroid size and control bleeding before planned surgery (myomectomy or hysterectomy), and intermittent treatment (in repeated courses with treatment-free intervals) in women for whom surgery is not currently appropriate, has failed, or is not desired, under specialist supervision with liver monitoring.
- Not indicated: Long-term continuous (uninterrupted) use, use simply to relieve symptoms while awaiting surgery without a defined treatment plan, and use in postmenopausal women.
Note: This bracketed indication of Ulipristal Acetate [For uterine fibroids] is distinct from the separate emergency-contraception use and dosing of ulipristal acetate, which is not covered by this entry.
Dosage & Administration of Ulipristal Acetate [For uterine fibroids]
Treatment with Ulipristal Acetate [For uterine fibroids] should be initiated and supervised by a physician experienced in the diagnosis and treatment of uterine fibroids, with pregnancy excluded before starting.
| Indication | Dose | Duration |
|---|---|---|
| Pre-operative treatment | One 5 mg tablet by mouth once daily, started within the first week of the menstrual cycle | Up to 3 months, single course |
| Intermittent treatment (surgery not appropriate/failed) | One 5 mg tablet once daily, started within the first week of each menstrual cycle | Repeated courses of up to 3 months each, separated by a treatment-free interval (allowing a menstrual bleed) between courses, with mandatory liver monitoring between courses |
Tablets may be taken with or without food. If a dose is missed, it should be taken as soon as possible; if more than 12 hours late, the missed dose should be skipped and the next tablet taken at the usual time. Ulipristal Acetate [For uterine fibroids] is not intended for continuous, uninterrupted long-term use outside a defined treatment-and-monitoring plan (see Precautions and Warnings).
Side Effects of Ulipristal Acetate [For uterine fibroids]
Reported adverse effects with Ulipristal Acetate [For uterine fibroids] include:
- Very common: Amenorrhea (absence of menstrual periods) during treatment, and endometrial thickening on imaging (generally reversible after stopping treatment).
- Common: Headache, dizziness, hot flushes, abdominal pain, nausea, acne, weight gain, breast tenderness, fatigue, and emotional/mood changes.
- Rare but serious: Severe liver injury, including cases requiring liver transplantation (see Precautions and Warnings for monitoring requirements).
Contraindications of Ulipristal Acetate [For uterine fibroids]
Ulipristal Acetate [For uterine fibroids] is contraindicated in patients with:
- Known hypersensitivity to ulipristal acetate or any excipient of the product.
- Known or suspected pregnancy.
- Undiagnosed abnormal uterine/genital bleeding not related to uterine fibroids.
- Known or suspected malignancy of the genital tract (uterine, cervical, ovarian, or breast cancer).
- Significant hepatic impairment.
Frequently Asked Questions about Ulipristal Acetate [For uterine fibroids]
What is Ulipristal Acetate [For uterine fibroids] used for?
Ulipristal Acetate [For uterine fibroids] is used in premenopausal women to treat moderate-to-severe symptoms of uterine fibroids, such as heavy menstrual bleeding and pelvic pain, either before surgery or as intermittent therapy when surgery is not currently suitable.
How is Ulipristal Acetate [For uterine fibroids] taken?
It is taken as one 5 mg tablet by mouth once daily, usually starting within the first week of your menstrual cycle, for a course of up to 3 months as directed by your physician.
Can Ulipristal Acetate [For uterine fibroids] be used during pregnancy?
No. Ulipristal Acetate [For uterine fibroids] is contraindicated in known or suspected pregnancy. Pregnancy must be ruled out before starting treatment, and effective non-hormonal (barrier) contraception should be used during treatment and for a period after stopping, since hormonal contraceptives may be less reliable when used together with this medicine.
Is Ulipristal Acetate [For uterine fibroids] safe for the liver?
Rare but serious cases of liver injury, including cases requiring liver transplantation, have been reported with Ulipristal Acetate [For uterine fibroids]. Your doctor will check your liver function before, during, and after each treatment course. Seek immediate medical attention if you notice yellowing of the skin or eyes, dark urine, unusual tiredness, nausea, or vomiting while taking this medicine.
Will my periods stop while taking Ulipristal Acetate [For uterine fibroids]?
Yes, it is very common to have little or no menstrual bleeding (amenorrhea) while taking Ulipristal Acetate [For uterine fibroids]; this is expected and usually returns to normal after each treatment course ends. Unusually heavy or persistent bleeding should be reported to your doctor.
Can Ulipristal Acetate [For uterine fibroids] be used long-term without breaks?
No. Ulipristal Acetate [For uterine fibroids] is intended for defined treatment courses, typically up to 3 months each, with liver monitoring and treatment-free intervals between courses. It should not be used continuously for long periods without medical supervision and monitoring.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.