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Napa500 mg
Beximco Pharmaceuticals Ltd.
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Ace500 mg
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Medicine overview
Indications of Ace 500 mg
Ace 500 mg is indicated for fevercommon cold and influenzaheadachetoothacheearachebodyachemyalgianeuralgiadysmenorrhoeasprainscolic painback painpost-operative painpostpartum pain
Theropeutic Class
Non opioid analgesics
Pharmacology
Ace 500 mg has analgesic and antipyretic properties with weak anti-inflammatory activity.
Absorption
Ace 500 mg (Acetaminophen) is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis.
Distribution
Ace 500 mg is a para aminophenol derivative, has analgesic and antipyretic properties with weak anti-inflammatory activity.
Metabolism
Ace 500 mg is one of the most widely used, safest and fast acting analgesic.
Excretion
It is well tolerated and free from various side effects of aspirin.
Dosage & Administration of Ace 500 mg
Tablet
Dosage:Adult : 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily
Children (6-12 years)
Dosage:½ to 1 tablet 3 to 4 times daily
Notes:For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day
Extended Release Tablet
Dosage:Adults & Children over 12 years : Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours)
Notes:The tablet must not be crushed
Syrup/Suspension
Dosage:Children under 3 months : 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily
Notes:3 months to below 1 yea r: ½ to 1 teaspoonful 3 to 4 times daily. 1-5 years : 1 -2 teaspoonful 3 to 4 times daily. 6-12 years : 2-A teaspoonful 3 to 4 times daily
Adults
Dosage:4-8 teaspoonful 3 to 4 times daily
Suppository
Dosage:Children 3-12 months : 60-120 mg,4 times daily
Children 1-5 years
Dosage:125-250 mg 4 times daily
Children 6-12 years
Dosage:250-500 mg 4 times daily
Adults & children over 12 years
Dosage:0.5-1 gm 4 times daily
Paediatric Drop
Dosage:Children Upto 3 months : 0.5 ml (40 mg) 4 to 11 months : 1.0 ml (80 mg) 7 to 2 years : 1.5 ml (120 mg)
Notes:Do not exceed more than 5 dose daily for a maximum of 5 days
Ace 500 mg tablet with actizorb technology
Dosage:It dissolves up to five times faster than standard Ace 500 mg tablets
Notes:It is a fast acting and safe analgesic with marked antipyretic property. It is specially suitable for patients who, for any reason, can not tolerate aspirin or other analgesics
Adults and children (aged 12 years and over)
Dosage:Take 1 to 2 Tablets every four to six hours as needed
Notes:Do not take more than 8 caplets in 24 hours
Children (7 to 11 years)
Dosage:Take ½-1 Tablet every four to six hours as needed
Notes:Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years
| Condition | Dosage | Notes |
|---|---|---|
| Tablet | Adult : 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily | |
| Children (6-12 years) | ½ to 1 tablet 3 to 4 times daily | For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day |
| Extended Release Tablet | Adults & Children over 12 years : Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours) | The tablet must not be crushed |
| Syrup/Suspension | Children under 3 months : 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily | 3 months to below 1 yea r: ½ to 1 teaspoonful 3 to 4 times daily. 1-5 years : 1 -2 teaspoonful 3 to 4 times daily. 6-12 years : 2-A teaspoonful 3 to 4 times daily |
| Adults | 4-8 teaspoonful 3 to 4 times daily | |
| Suppository | Children 3-12 months : 60-120 mg,4 times daily | |
| Children 1-5 years | 125-250 mg 4 times daily | |
| Children 6-12 years | 250-500 mg 4 times daily | |
| Adults & children over 12 years | 0.5-1 gm 4 times daily | |
| Paediatric Drop | Children Upto 3 months : 0.5 ml (40 mg) 4 to 11 months : 1.0 ml (80 mg) 7 to 2 years : 1.5 ml (120 mg) | Do not exceed more than 5 dose daily for a maximum of 5 days |
| Ace 500 mg tablet with actizorb technology | It dissolves up to five times faster than standard Ace 500 mg tablets | It is a fast acting and safe analgesic with marked antipyretic property. It is specially suitable for patients who, for any reason, can not tolerate aspirin or other analgesics |
| Adults and children (aged 12 years and over) | Take 1 to 2 Tablets every four to six hours as needed | Do not take more than 8 caplets in 24 hours |
| Children (7 to 11 years) | Take ½-1 Tablet every four to six hours as needed | Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years |
Interaction of Ace 500 mg
Patients who have taken barbiturates, tricyclic antidepressants and alcohol may show diminished ability to metabolise large doses of Ace 500 mg. Alcohol can increase the hepatotoxicity of Ace 500 mg overdosage. Chronic ingestion of anticonvulsants or oral steroid contraceptives induce liver enzymes and may prevent attainment of therapeutic Ace 500 mg levels by increasing first-pass metabolism or clearance.
Contraindications
It is contraindicated in known hypersensitivity to Ace 500 mg.
Side Effects of Ace 500 mg
Side effects of Ace 500 mg are usually mild, though haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.
Pregnancy & Lactation
Pregnancy category B according to USFDA. This drug should be used during pregnancy only if clearly needed
Precautions & Warnings
Ace 500 mg should be given with caution to patients with impaired kidney or liver function. Ace 500 mg should be given with care to patients taking other drugs that affect the liver.
Overdose Effects of Ace 500 mg
Symptoms of Ace 500 mg overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12-48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
Drug Classes
Non opioid analgesics
Mode Of Action
Ace 500 mg has analgesic and antipyretic properties with weak anti-inflammatory activity. Ace 500 mg (Acetaminophen) is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Ace 500 mg is a para aminophenol derivative, has analgesic and antipyretic properties with weak anti-inflammatory activity. Ace 500 mg is one of the most widely used, safest and fast acting analgesic. It is well tolerated and free from various side effects of aspirin.
Pregnancy
Pregnancy category B according to USFDA. This drug should be used during pregnancy only if clearly needed. Ace 500 mg is excreted in breast milk. Maternal ingestion of Ace 500 mg in normal therapeutic doses does not appear to present a risk to the nursing infant.
Frequently Asked Questions
What is Ace 500 mg used for?
Paracetamol is indicated for fever, common cold and influenza, headache, toothache, earache, bodyache, myalgia, neuralgia, dysmenorrhoea, sprains, colic pain, back pain, post-operative pain, postpartum pain, inflammatory pain and post vaccination pain in children. It is also indicated for rheumatic & osteoarthritic pain and stiffness of joints.
What is the dosage of Ace 500 mg?
Tablet: Adult : 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily. Children (6-12 years) : ½ to 1 tablet 3 to 4 times daily. For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day. Extended Release Tablet: Adults & Children over 12 years : Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours).The tablet must not be crush…
What are the side effects of Ace 500 mg?
Side effects of paracetamol are usually mild, though haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.
Who should not take Ace 500 mg?
It is contraindicated in known hypersensitivity to Paracetamol.
What precautions should be taken with Ace 500 mg?
Paracetamol should be given with caution to patients with impaired kidney or liver function. Paracetamol should be given with care to patients taking other drugs that affect the liver.
Is Ace 500 mg safe during pregnancy and breastfeeding?
Pregnancy category B according to USFDA. This drug should be used during pregnancy only if clearly needed
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.