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Pedeamin100 ml
Diphenhydramine Hydrochloride
Beximco Pharmaceuticals Ltd.
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Adryl100 ml
Syrup
Diphenhydramine Hydrochloride
Square Pharmaceuticals PLC.
Product Code : 357
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Medicine overview
Indications of Adryl 100 ml
Diphenhydramine is indicated for the treatment of followings:
Seasonal, perennial, vasomotor rhinitis
Urticaria, angioneurotic oedema, anaphylaxis
Pruiritic conditions
Premedication for emesis and motion sickness
Miscellaneous like meniere's disease and parkinsonism
Theropeutic Class
Sedating Anti-histamine
Pharmacology
Diphenhydramine is an antihistamine with anticholinergic and sedative effects. It competes with histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and respiratory tract.
Dosage & Administration of Adryl 100 ml
Adult-
Most allergic conditions: 25-50 mg three times a day with a further 50 mg at night.
Children-
1 to 5 years of age: 5 mg i.e., 2.5 ml of elixir 4 times a day
More than 6 years of age: 10 mg i.e. 5 ml of elixir 4 times a day
Dosage of Adryl 100 ml
Adult-
Most allergic conditions: 25-50 mg three times a day with a further 50 mg at night.
Children-
1 to 5 years of age: 5 mg i.e., 2.5 ml of elixir 4 times a day
More than 6 years of age: 10 mg i.e. 5 ml of elixir 4 times a day
Interaction of Adryl 100 ml
Diphenhydramine administration significantly reduces the absorption of the antituberculous agent para-aminosalicyclic acid (PAS) from the gastrointestinal tract. CNS depressants may potentiate the sedative action of Diphenhydramine. Anticholinergic drugs may potentiate Diphenhydramine’s anticholinergic side effects.
Contraindications
Known hypersensitivity to Adryl 100 ml, Ammonium chloride is contra-indicated in presence of impaired hepatic or renal function.
Side Effects of Adryl 100 ml
Side effect includes sedation, dizziness, tinnitus, fatigue, ataxia, blurred vision, diplopia, euphoria, and epigastric discomfort.
Pregnancy & Lactation
Category B: There are no adequate and well controlled studies in pregnant women using Adryl 100 ml. Therefore, Adryl 100 ml should be used in pregnancy only if clearly needed. Diphenhydramine hydrochloride has been reported to be excreted in breast milk and thus, use of Adryl 100 ml in lactating mother is not recommended.
Precautions & Warnings
Caution should be exercised with patients in whom drowsiness is undesirable e.g., drivers, machine operators. Concomitant consumption of alcohol or central nervous system (CNS) depressants will potentiate drowsiness.
Overdose Effects of Adryl 100 ml
Symptoms: Impaired consciousness; psychosis, seizures, antimuscarinic symptoms (e.g. mydriasis, tachycardia, tachyarrhythmias), resp failure, rhabdomyolysis; acute delirium with visual and auditory hallucination (topical). Management: Supportive and symptomatic treatment. Convulsions and marked CNS stimulation may be treated with IV diazepam.
Storage Conditions
Store between 15-30° C. Protect from moisture.
Drug Classes
Sedating Anti-histamine
Mode Of Action
Diphenhydramine is an antihistamine with anticholinergic and sedative effects. It competes with histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and respiratory tract.
Pregnancy
Category B: There are no adequate and well controlled studies in pregnant women using Adryl 100 ml. Therefore, Adryl 100 ml should be used in pregnancy only if clearly needed. Diphenhydramine hydrochloride has been reported to be excreted in breast milk and thus, use of Adryl 100 ml in lactating mother is not recommended.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.
