Alvita100 mg+200 mg+200 mcg

Alvita is a combination of three essential water-soluble B-vitamins - thiamine (B1), pyridoxine (B6), and cobalamin (B12) - indicated for the following:

Established Uses

• Prevention and treatment of dietary deficiency or increased requirement of vitamin B1, B6, and B12, including in malabsorption states, poor dietary intake, chronic alcohol use, and certain chronic illnesses.

Guideline-Supported / Adjunct Uses

• Adjunct symptomatic treatment of peripheral neuropathy and neuralgia (for example, diabetic peripheral neuropathy or alcohol-related neuropathy), used together with treatment directed at the underlying cause, not as a substitute for it.
• Supportive therapy in neuritis, polyneuritis, and other nerve disorders associated with B-vitamin deficiency or depletion.

Note: Alvita is a nutritional supplement/adjunct therapy and does not replace proper medical evaluation and treatment of the underlying cause of neuropathy or deficiency symptoms.

Each formulation of Vitamin B1, B6 and B12 contains a combination of Thiamine (Vitamin B1), Pyridoxine hydrochloride (Vitamin B6), and Cyanocobalamin or Methylcobalamin (Vitamin B12). Exact strengths vary by brand and dosage form (tablet, capsule, or injectable solution); refer to the specific product label for the precise composition.

Alvita is a fixed-dose combination nutritional supplement of three essential B-complex vitamins that play interconnected roles in energy metabolism, nervous system function, and red blood cell production.

Thiamine (B1) is a cofactor in carbohydrate metabolism and nerve conduction; pyridoxine (B6) is involved in amino acid metabolism and neurotransmitter synthesis; and cobalamin (B12) is essential for DNA synthesis, myelin formation, and healthy nerve function. Together, Alvita is used to correct or prevent deficiency of these vitamins and to provide adjunct support in certain neuropathic conditions.

Vitamin B-Complex / Neurotropic Vitamin Supplement (Alvita)

Vitamin B1, B6 and B12 combines three vitamins with complementary metabolic and neurological roles:

• Thiamine (B1): Acts as a cofactor (as thiamine pyrophosphate) for enzymes in carbohydrate metabolism and is required for normal nerve cell function and conduction.
• Pyridoxine (B6): Converted to pyridoxal-5-phosphate, an essential cofactor for amino acid metabolism, neurotransmitter (e.g., GABA, serotonin) synthesis, and hemoglobin formation.
• Cobalamin (B12): Required as a cofactor for DNA synthesis and for maintenance of the myelin sheath surrounding peripheral nerves; deficiency impairs nerve conduction and red blood cell maturation.

By replenishing these cofactors, Vitamin B1, B6 and B12 supports normal neuronal metabolism and may help relieve neuropathic symptoms associated with deficiency, used as an adjunct alongside treatment of the underlying cause.

Oral forms of Alvita may be taken with or after food to reduce the chance of stomach upset. Swallow tablets/capsules whole with water; do not crush or chew unless the product is designed for it.

Injectable forms of Alvita are for intramuscular administration by a qualified healthcare professional only and should not be self-administered.

Alvita has the following clinically significant interactions:

• Levodopa (without carbidopa): Pyridoxine (B6) can reduce the effectiveness of levodopa given alone by enhancing its peripheral breakdown; this interaction is not significant when levodopa is combined with carbidopa.
• Phenytoin, phenobarbital: Pyridoxine may lower plasma levels of these anticonvulsants in some patients; monitor for reduced seizure control with concurrent high-dose use.
• Chloramphenicol: May antagonize the hematologic response to vitamin B12 in patients being treated for B12 deficiency anemia.

Inform your physician of all medicines and supplements you are taking before starting Alvita.

At standard supplement/deficiency-treatment doses, Alvita is generally very well tolerated. Reported side effects are usually mild and may include:

• Nausea or mild gastrointestinal upset
• Headache
• Injection site pain, redness, or induration (with intramuscular injection)
• Rare hypersensitivity reactions (skin rash, itching; rarely anaphylaxis, more often reported with parenteral thiamine)

See Precautions and Warnings for the risk of peripheral neuropathy associated with prolonged high-dose pyridoxine (B6).

Vitamins B1, B6, and B12 are required nutrients during pregnancy and lactation at recommended dietary allowance (RDA) levels. However, formal safety data for Alvita as a combination product, particularly at doses above the RDA, are limited. Alvita should be used during pregnancy and breastfeeding only if clearly needed and only in doses recommended by a physician; potential benefit should be weighed against any potential risk. Consult a physician before use.

The following precautions apply to Alvita:

• Prolonged high-dose pyridoxine (B6): High-dose or prolonged use of pyridoxine, well above typical supplement/deficiency-treatment ranges, has been associated in rare cases with peripheral sensory neuropathy - a recognized paradoxical risk. Avoid prolonged high-dose use without medical supervision.
• Masking of folate deficiency: Vitamin B12 in Alvita can improve the hematologic (blood count) abnormalities of megaloblastic anemia due to folate deficiency without correcting the underlying folate deficiency or preventing progression of associated neurological damage. Folate status should be evaluated before or during treatment when megaloblastic anemia is being investigated.
• Not a substitute for definitive treatment: Alvita does not replace evaluation and treatment of the underlying cause of neuropathy or deficiency symptoms. Persistent or worsening neurological symptoms warrant prompt medical evaluation.
• Parenteral use: Rare hypersensitivity and anaphylactoid reactions have been reported with injectable thiamine and B12; injections should be given under appropriate medical supervision.

Significant overdose with usual oral doses of Alvita is uncommon because B1, B6, and B12 are water-soluble and excess is largely excreted in urine; however, chronic excessive intake of pyridoxine (B6) in particular can cause sensory neuropathy (numbness, tingling, unsteady gait). If overdose is suspected or a large amount has been taken, seek immediate medical attention or contact a poison control center/emergency services rather than attempting home treatment. Do not exceed the dose prescribed by your physician.

Store at room temperature (below 30°C), away from light and moisture. Keep out of reach of children.

Elderly: Alvita may be used in elderly patients, who are at higher risk of B-vitamin deficiency; no specific dose reduction is generally required, but renal function should be considered.

Renal impairment: Use with caution; water-soluble vitamin clearance may be reduced. See Precautions and Warnings regarding high-dose B6.

Hepatic impairment: No well-established dose adjustment is required, but use under medical supervision.

Pregnancy and lactation: See Pregnancy and Lactation section.

Children: See Pediatric Uses section.

Duration of treatment with Alvita depends on the indication - deficiency correction typically requires several weeks to months, while adjunct use for neuropathy symptoms is often continued for a longer, physician-directed course alongside treatment of the underlying cause. Do not continue high-dose therapy longer than advised by your physician.

Vitamin B Complex; Water-soluble vitamins; Neurotropic vitamin supplement

Vitamin B1, B6 and B12 works by replenishing three interrelated water-soluble vitamin cofactors: thiamine (as thiamine pyrophosphate) supports carbohydrate metabolism and nerve conduction; pyridoxine (as pyridoxal-5-phosphate) supports amino acid and neurotransmitter metabolism; and cobalamin supports DNA synthesis and maintenance of the myelin sheath of peripheral nerves. Correcting deficiency of these cofactors supports normal nerve cell metabolism and function.

Alvita may be used in children to treat or prevent diagnosed deficiency of vitamins B1, B6, and B12, under medical supervision and with age-appropriate, weight-based dosing as directed by a physician. Safety and efficacy of Alvita for the adjunct peripheral neuropathy indication have not been established in the pediatric population, and this use is generally reserved for adults.