Anosil

Anosil is a combination topical/rectal preparation indicated for the symptomatic relief of the discomfort associated with hemorrhoids (piles) and other minor anorectal conditions.

• Established use: Short-term relief of pain, itching (pruritus ani), burning, soreness, and swelling caused by internal and external hemorrhoids.
• Guideline/clinical-practice-supported use: Adjunctive symptomatic management of minor anal fissures and proctitis-related discomfort, alongside dietary/lifestyle measures (fiber, hydration, sitz baths) that address the underlying cause.
• Not indicated for: Treatment of the underlying cause of hemorrhoids, thrombosed hemorrhoids requiring surgical management, or anorectal infections (see Contraindications).

Anosil provides symptomatic comfort only; it does not cure hemorrhoids or address their underlying cause.

Hydrocortisone Acetate + Benzyl Benzoate + Bismuth Subgallate + Bismuth Oxide + Balsam Peru + Zinc Oxide is a fixed multi-ingredient anorectal preparation (ointment/suppository). A typical formulation contains, per gram of ointment or per suppository, approximately:

• Hydrocortisone acetate 0.5% w/w
• Benzyl benzoate ~1.2% w/w
• Bismuth subgallate ~2.25% w/w
• Bismuth oxide ~0.875% w/w
• Balsam Peru ~1.85% w/w
• Zinc oxide (quantity varies by brand/formulation)

Exact strengths vary by manufacturer and dosage form; refer to the specific product label/pack insert for the exact composition of the brand dispensed.

Anosil is a fixed-dose combination anorectal preparation available as an ointment and/or suppository, formulated to relieve the pain, itching, and inflammation of hemorrhoids while providing a protective, astringent barrier over irritated anorectal tissue.

It combines a low-potency topical corticosteroid (hydrocortisone acetate) for anti-inflammatory action with astringent/protectant agents (bismuth subgallate, bismuth oxide, zinc oxide), a soothing natural balsam (Balsam Peru), and benzyl benzoate, which contributes a mild soothing/antipruritic effect within the combination.

Anosil belongs to the therapeutic class of anorectal preparations (hemorrhoidal products) combining a topical corticosteroid with astringents/protectants, used for local symptomatic treatment of hemorrhoids and related anorectal discomfort.

Hydrocortisone Acetate + Benzyl Benzoate + Bismuth Subgallate + Bismuth Oxide + Balsam Peru + Zinc Oxide acts through the complementary local actions of its components:

• Hydrocortisone acetate: a low-potency corticosteroid that reduces local inflammation, itching, and swelling by inhibiting phospholipase A2 and downstream synthesis of prostaglandins and leukotrienes, and by producing local vasoconstriction.
• Bismuth subgallate and bismuth oxide: insoluble bismuth salts that form a protective, mildly astringent coating over inflamed or excoriated anorectal mucosa, reducing oozing and mechanical irritation.
• Zinc oxide: an astringent skin protectant that forms a physical barrier, has mild antiseptic properties, and reduces weeping of irritated tissue.
• Balsam Peru: a natural resin with mild antiseptic and vulnerary (wound-healing-promoting) properties that supports epithelial repair and provides a soothing effect.
• Benzyl benzoate: included at low concentration for its mild soothing and antipruritic contribution within the combination.

Systemic absorption of hydrocortisone acetate through intact anorectal mucosa is generally minimal with short-term, as-directed use, but can increase with prolonged application, use on broken skin, or occlusion.

For external (perianal) or rectal use only. Wash and dry the anal area gently before application. For ointment, apply a small amount externally, or use with an applicator for lower rectal application if provided by the manufacturer. For suppositories, insert the suppository well into the rectum, pointed end first. Wash hands before and after use. Anosil is not for oral, ophthalmic, or intravaginal use.

Significant systemic drug interactions with Anosil are unlikely when it is used topically/rectally as directed for short periods, because systemic absorption is minimal.

• Other corticosteroids (topical, rectal, inhaled, or systemic): concurrent use may have an additive effect on systemic corticosteroid absorption/exposure, particularly with prolonged use, large treatment areas, or use on broken skin; avoid unnecessary combined corticosteroid use.
• Other rectal/anal products: avoid concurrent use of additional topical anorectal products unless advised by a physician, to prevent excessive local drug exposure.

Side effects with Anosil are generally local and mild when used as directed:

• Local burning, stinging, or itching at the application site
• Skin dryness, irritation, or mild rash
• Allergic or irritant contact dermatitis, most often attributable to Balsam Peru or benzyl benzoate
• With prolonged or excessive use: skin thinning (atrophy), striae, or telangiectasia at the application site due to the corticosteroid component
• Rarely, systemic hypersensitivity reactions

If irritation, rash, or sensitization develops, discontinue Anosil and seek medical advice.

Pregnancy: There are no well-controlled studies of Anosil in pregnant women. Topical/rectal corticosteroids have limited systemic absorption when used as directed for short periods, but Anosil should be used during pregnancy only if clearly needed, at the lowest effective dose for the shortest duration, and only after consulting a physician.

Lactation: It is not known whether topical hydrocortisone or the other components are excreted in clinically significant amounts in breast milk. Use during breastfeeding only if a physician advises it, and avoid application to areas that may come into direct contact with the infant.

• For external/rectal use only; avoid contact with the eyes.
• Do not use for longer than 7 consecutive days unless directed by a physician, because of the risk of local corticosteroid side effects (skin atrophy) and increased systemic absorption with prolonged use.
• Discontinue Anosil and consult a physician if irritation, sensitization, worsening symptoms, or an allergic reaction develops (see Side Effects).
• Do not use in the presence of an untreated anorectal infection (see Contraindications).
• If rectal bleeding, severe pain, a palpable lump, or symptoms that do not improve within 7 days occur, seek prompt medical evaluation, as these may indicate a condition other than simple hemorrhoids.
• Avoid use over large areas of broken or denuded skin, or under occlusive dressings, unless directed by a physician.
• Keep out of reach of children.

Anosil is intended for local topical/rectal use, and significant systemic toxicity from an accidental single excess application is unlikely. However, in the event of accidental oral ingestion, application of an excessive amount, or symptoms suggestive of systemic absorption (e.g., unusual swelling, weight gain, mood changes), seek immediate medical attention or contact a poison control center. Do not attempt specific home treatment for suspected overdose; get professional medical guidance promptly.

Store at room temperature (below 30°C), away from direct light and moisture. If supplied as suppositories, they may soften in heat; keep in a cool place (refrigeration is not required unless specified on the pack) and avoid storing near heat sources. Keep out of reach of children.

• Pediatric patients: Use of Anosil in children under 12 years is not recommended without medical advice; safety and efficacy have not been established in this age group.
• Elderly: No specific dose adjustment is established; use the standard adult regimen with the same precautions regarding duration of use.
• Renal or hepatic impairment: No specific dose adjustment is established for topical/rectal use, as systemic exposure is minimal with short-term, as-directed use.
• Pregnancy and lactation: See Pregnancy and Lactation section.

Anosil is intended for short-term symptomatic use, generally not exceeding 7 consecutive days, unless a physician directs otherwise. If symptoms have not improved, or worsen, within this period, medical review is recommended before continuing treatment, to rule out other anorectal conditions and to limit corticosteroid-related risks from prolonged use.

Hydrocortisone Acetate + Benzyl Benzoate + Bismuth Subgallate + Bismuth Oxide + Balsam Peru + Zinc Oxide is classified as a topical corticosteroid combined with astringent/protectant agents in a fixed-dose anorectal (hemorrhoidal) preparation.

Hydrocortisone Acetate + Benzyl Benzoate + Bismuth Subgallate + Bismuth Oxide + Balsam Peru + Zinc Oxide works through combined anti-inflammatory, astringent, protective, and soothing actions: hydrocortisone acetate suppresses local inflammatory mediators to reduce swelling and itching; bismuth subgallate, bismuth oxide, and zinc oxide form an astringent protective coating that reduces oozing and shields irritated mucosa; Balsam Peru supports local wound healing and has mild antiseptic activity; and benzyl benzoate contributes additional soothing/antipruritic effect. Together these components provide multi-modal symptomatic relief of hemorrhoidal discomfort.

Anosil is not recommended for use in children under 12 years of age without specific medical advice, as safety and efficacy have not been established in the pediatric population for this combination product. If a physician determines use is necessary in an older child or adolescent, the lowest effective amount should be used for the shortest possible duration, following the same 7-day maximum guidance as in adults, with close monitoring for local corticosteroid side effects.