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Citivas500 mg
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Medicine overview
Indications of Citivas 500 mg
Citivas 500 mg is indicated in- Cerebrovascular disease e.g. ischemia due to strokememory loss
Theropeutic Class
CNS stimulant drugs
Pharmacology
Citicoline is a naturally occurring, water-soluble biological compound that is essential intermediate for the synthesis of phosphatidylcholine, a major constituent of the gray matter of brain tissue.
Absorption
Citicoline seems to increase a brain chemical called phosphatidylcholine.
Distribution
Citicoline might also decrease brain tissue damage when the brain is injured.
Metabolism
Citicoline promotes brain metabolism by enhancing the synthesis of acetylcholine and restoring phospholipid content in the brain. It also elevates brain oxygen consumption and improves brain metabolism.
Dosage & Administration of Citivas 500 mg
Disturbance of Consciousness
Dosage:Due to Head Injury or Brain Surgery: 100-500 mg 1-2 times daily
Psychologic or Neurologic Disorders
Dosage:Disturbance of Consciousness in the Acute Stage of Cerebral Infarction: 1000 mg once daily for 2 consecutive weeks or as prescribed by the physician
| Condition | Dosage | Notes |
|---|---|---|
| Disturbance of Consciousness | Due to Head Injury or Brain Surgery: 100-500 mg 1-2 times daily | |
| Psychologic or Neurologic Disorders | Disturbance of Consciousness in the Acute Stage of Cerebral Infarction: 1000 mg once daily for 2 consecutive weeks or as prescribed by the physician |
Dosage of Citivas 500 mg
Oral
Dosage:Immediate treatment of stroke due to a clot (ischemic stroke): 500-2000 mg of Citicoline per day, start within 24 hours of stroke
For decline in thinking skills due to stroke
Dosage:1000-2000 mg of Citicoline per day
Chronic cerebrovascular disease
Dosage:1000 mg daily in divided dose with or between meals for ongoing disease of the blood vessels that serve the brain
Injection
Dosage:1 to 2 injections daily
Notes:Adjust dosage according to the severity. Can be administered through intramuscular (IM), or intravenous (IV) [ 3 to 5 minutes] route
| Condition | Dosage | Notes |
|---|---|---|
| Oral | Immediate treatment of stroke due to a clot (ischemic stroke): 500-2000 mg of Citicoline per day, start within 24 hours of stroke | |
| For decline in thinking skills due to stroke | 1000-2000 mg of Citicoline per day | |
| Chronic cerebrovascular disease | 1000 mg daily in divided dose with or between meals for ongoing disease of the blood vessels that serve the brain | |
| Injection | 1 to 2 injections daily | Adjust dosage according to the severity. Can be administered through intramuscular (IM), or intravenous (IV) [ 3 to 5 minutes] route |
Interaction of Citivas 500 mg
Citicoline may enhance the effects of levodopa, carbidopa & entacapone. Citicoline must not be administered with products containing meclophenoxate.
Contraindications
Patients with hypertonic of the parasympathetic nervous system.
Side Effects of Citivas 500 mg
Occasionally Citicoline may exert stimulating action of the parasympathetic system as well as a fleeting & discrete hypotensive effect.
Pregnancy & Lactation
There is inadequate evidence of safe use of citicoline in human pregnancy. Citicoline should be used in pregnancy and lactation only if the potential benefits justify the potential risks.
Precautions & Warnings
In case of persistent intracranial hemorrhage, it is recommended not to exceed the dose of 1000 mg of Citicoline daily.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Drug Classes
CNS stimulant drugs
Mode Of Action
Citicoline is a naturally occurring substance that is an essential intermediate in the synthesis of structural phospholipids of cell membrane. Oral dose of Citicoline is metabolized to choline & cytidine. These then enter into the systemic circulation, cross the blood-brain barrier and recombine to form Citicoline within the central nervous system. Citicoline activates the biosynthesis of structural phospholipids in the neuronal membrane, promotes rapid repair of injured cell surface & mitochondrial membrane & increases the level of various neurotransmitters like acetylcholine & dopamine. Citicoline has neuroprotective effects in situations of hypoxia & ischemia, as well as improved learning & memory performance in animal models for the aging brain. Citicoline inhibits the activation of Phospholipase A2 to prevent apoptotic & necrotic cell death.
Pregnancy
There are no adequate & well controlled studies of Citicoline during pregnancy & lactation. Citicoline should be used during pregnancy & lactation only if the potential benefits justify the potential risks.
Pediatric Uses
Geriatric use: No dosage adjustment is required & the usual dose can be administered.
Frequently Asked Questions
What is Citivas 500 mg used for?
Citicoline Sodium is indicated in- Cerebrovascular disease e.g. ischemia due to stroke, where Citicoline accelerates the recovery of consciousness & overcoming motor deficit. Treatment within the first 24 hours after onset in patients with moderate to severe stroke increases the probability of complete recovery in 3 months. ... Read moreCiticoline Sodium is indicated in- Cerebrovascular disease e.…
What is the dosage of Citivas 500 mg?
Oral: Immediate treatment of stroke due to a clot (ischemic stroke): 500-2000 mg of Citicoline per day, start within 24 hours of stroke. For decline in thinking skills due to stroke: 1000-2000 mg of Citicoline per day. Chronic cerebrovascular disease: 1000 mg daily in divided dose with or between meals for ongoing disease of the blood vessels that serve the brain. Injection: 1 to 2 injections dail…
What are the side effects of Citivas 500 mg?
Occasionally Citicoline may exert stimulating action of the parasympathetic system as well as a fleeting & discrete hypotensive effect.
Who should not take Citivas 500 mg?
Patients with hypertonic of the parasympathetic nervous system.
What precautions should be taken with Citivas 500 mg?
In case of persistent intracranial hemorrhage, it is recommended not to exceed the dose of 1000 mg of Citicoline daily.
Is Citivas 500 mg safe during pregnancy and breastfeeding?
There is inadequate evidence of safe use of citicoline in human pregnancy. Citicoline should be used in pregnancy and lactation only if the potential benefits justify the potential risks.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.