Des

Des2.5 mg/5 ml

Syrup

Desloratadine

Opsonin Pharma Ltd.

Product Code : 4681
MRP 30.00
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Medicine overview

Indications of Des 2.5 mg/5 ml

Des 2.5 mg/5 ml is indicated for the relief of symptoms associated with seasonal and perennial allergic rhinitis, such as sneezing, nasal discharge & itching, congestion or stuffiness, as well as ocular itching, tearing and redness, itching of palate and coughing. Des 2.5 mg/5 ml is also indicated for ... Read moreDes 2.5 mg/5 ml is indicated for the relief of symptoms associated with seasonal and perennial allergic rhinitis, such as sneezing, nasal discharge & itching, congestion or stuffiness, as well as ocular itching, tearing and redness, itching of palate and coughing. Des 2.5 mg/5 ml is also indicated for the relief of symptoms associated with chronic idiopathic urticaria such as the relief of itching and the size & number of hives.

Theropeutic Class

Non-sedating antihistamines

Pharmacology

Des 2.5 mg/5 ml is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.

Dosage & Administration of Des 2.5 mg/5 ml

Pediatric drops : Child 6 -11 months of age: 2 ml drops once daily Child 1 -2 years of age: 2.5 ml drops once daily Syrup: Child 6-11 months of age: 2 ml once daily Child 1-5 years of age: 2.5 ml once daily Child 6-11 years of age: 5 ml once daily Adults & > 12 years of age: 10 ml once daily Tablet: Adults and children 12 years of age and over: 5 mg daily

Dosage of Des 2.5 mg/5 ml

Pediatric drops: Child 6-11 months of age: 2 ml drops once daily. Child 1-2 years of age: 2.5 ml drops once daily. Syrup: Child 6-11 months of age: 2 ml once daily. Child 1-5 years of age: 2.5 ml once daily. Child 6-11 years of age: 5 ml once daily. Adults & >12 years of age: 10 ml once daily. Tablet: Adults and children 12 years of age and over: 1 tablet daily

Interaction of Des 2.5 mg/5 ml

No clinically relevant drug interactions have been reported.

Contraindications

Des 2.5 mg/5 ml is contraindicated in patients having hypersensitivity to this medication or to any of its ingredients or Loratadine.

Side Effects of Des 2.5 mg/5 ml

Less common side effects may include headache, nausea, fatigue, dizziness, pharyngitis, dyspepsia and myalgia.

Pregnancy & Lactation

Pregnancy: There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Des 2.5 mg/5 ml should be used in pregnancy only if clearly needed. Lactation: Des 2.5 mg/5 ml passes into breast milk. Therefore, a decision should be made whether to discontinue nursing or to discontinue Des 2.5 mg/5 ml, taking into account the importance of the drug to the mother.

Precautions & Warnings

In adult patients with liver or renal impairment: A starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data. If the patient has medical or familial history of seizures.

Overdose Effects of Des 2.5 mg/5 ml

No clinically relevant adverse effects have been reported.

Storage Conditions

Store in a cool & dry place, protected from light. Store below 30°C. Keep all medicines out of the reach of children.

Use In Special Populations

Paediatric Use: The safety and effectiveness of Des 2.5 mg/5 ml in pediatric patients under 2 years of age have not been established.Geriatric Use: In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.In adult patients with liver or renal impairment: A starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.

Drug Classes

Non-sedating antihistamines

Mode Of Action

Des 2.5 mg/5 ml, the major active metabolite of Loratadine, is a non-sedating; long acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity. Des 2.5 mg/5 ml also inhibits histamine release from human mast cell.

Pregnancy

Pregnancy Category C. The safe use of Des 2.5 mg/5 ml during pregnancy has not been established. Therefore, Des 2.5 mg/5 ml is not to be used during pregnancy unless clearly indicated. Des 2.5 mg/5 ml passes into breast milk, therefore a decision should be made whether to discontinue nursing or to discontinue Des 2.5 mg/5 ml taking into account the importance of the drug to the mother.

Pediatric Uses

Recommended in the use in children & adolescents.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.