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Clofenac Plus(75 mg+20
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Intafenac Plus(75 mg+20 mg)/2 ml
IM Injection
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Medicine overview
Indications of Intafenac Plus (75 mg+20 mg)/2 ml
osteoarthritisjuvenile chronic arthritisankylosing spondylitisacute gout. Acute musculoskeletal disorders such as periarthritis (e.g.Frozen shoulder)tendinitistenosynovitisosteoarthritisjuvenile chronic arthritisankylosing spondylitisacute gout. Acute musculoskeletal disorders such as periarthritis (e.g.Frozen shoulder)tendinitistenosynovitisbursitis. Other painful conditions resulting from trauma includingfracturelow back painsprainsstrainsdislocationscontrol of pain and inflammation in orthopaedicdental and other minor surgeriespostoperative painwhich is most likely to occur after intramuscular injectionis minimized if the Lidocaine containing injection is used in the above indications.
Theropeutic Class
Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Pharmacology
Diclofenac Sodium is a potent nonsteroidal antiinflammatory drug (NSAID) with marked analgesic and antipyretic properties.
Absorption
Peak plasma concentration is achieved within half an hour following injection.
Distribution
Diclofenac may inhibit synthesis of prostaglandins by inhibiting cyclooxygenase, an enzyme that catalyses the formation of prostaglandin precursors from arachidonic acid. Lidocaine is the most widely used local anaesthetic drug.
Metabolism
It acts more rapidly and is more stable than most other local anaesthetics. It is a very useful surface anaesthetic.
Excretion
Like other local anaesthetics, Lidocaine impairs the generation and conduction of nerve impulses by slowing depolarization. The onset of anaesthesia of Lidocaine Hydrochloride is more rapid and the duration is 1-2 hours.
Dosage & Administration of Intafenac Plus (75 mg+20 mg)/2 ml
Notes:Each 2 ml ampoule contains Diclofenac Sodium 75 mg and Lidocaine Hydrochloride 20 mg
Adults
Dosage:One ampoule once (or in severe cases, twice) daily by intramuscular injection
Renal colic
Dosage:One ampoule once daily intramuscularly
Notes:A further ampoule may be administered after 30 minutes, if necessary. The recommended maximum daily dose of diclofenac is 150 mg, by any route. The recommended maximum daily dose of lidocaine is 200 mg
Children
Dosage:In juvenile chronic arthritis, 1-3 mg of diclofenac/kg body wt
Notes:daily in divided doses
Elderly patients
Dosage:In elderly or debilitated patients, the lowest effective dosage is recommended, commensurate with age and physical status
| Condition | Dosage | Notes |
|---|---|---|
| Each 2 ml ampoule contains Diclofenac Sodium 75 mg and Lidocaine Hydrochloride 20 mg | ||
| Adults | One ampoule once (or in severe cases, twice) daily by intramuscular injection | |
| Renal colic | One ampoule once daily intramuscularly | A further ampoule may be administered after 30 minutes, if necessary. The recommended maximum daily dose of diclofenac is 150 mg, by any route. The recommended maximum daily dose of lidocaine is 200 mg |
| Children | In juvenile chronic arthritis, 1-3 mg of diclofenac/kg body wt | daily in divided doses |
| Elderly patients | In elderly or debilitated patients, the lowest effective dosage is recommended, commensurate with age and physical status |
Dosage of Intafenac Plus (75 mg+20 mg)/2 ml
Adult
Dosage:One ampoule once (or in severe cases, twice) daily by intramuscular injection
Renal colic
Dosage:One ampoule once daily intramuscularly
Notes:A second dose may be administered after 30 minutes if necessary
Children
Dosage:In Juvenile chronic arthritis, 1-3 mg of Diclofenac Sodium per kg body weight daily in divided doses
Elderly patients
Dosage:In elderly or debilitated patients, the lowest effective dosage is recommended, commensurate with age and physical status, or as prescribed by the physician
| Condition | Dosage | Notes |
|---|---|---|
| Adult | One ampoule once (or in severe cases, twice) daily by intramuscular injection | |
| Renal colic | One ampoule once daily intramuscularly | A second dose may be administered after 30 minutes if necessary |
| Children | In Juvenile chronic arthritis, 1-3 mg of Diclofenac Sodium per kg body weight daily in divided doses | |
| Elderly patients | In elderly or debilitated patients, the lowest effective dosage is recommended, commensurate with age and physical status, or as prescribed by the physician |
Interaction of Intafenac Plus (75 mg+20 mg)/2 ml
Lithium and Digoxin: Diclofenac may increase plasma concentrations of Lithium and Digoxin. Anticoagulants: There are isolated reports of an increased risk of haemorrhage with the combined use of Diclofenac and anticoagulant therapy, although clinical investigations do not appear to indicate any influence on anticoagulant effect. Antidiabetic agents: Clinical studies have shown that Diclofenac can be given together with oral antidiabetic agents without influencing their clinical effect. Cyclosporin: Cases of nephrotoxicity have been reported in patients receiving Cyclosporin and Diclofenac concomitantly. Methotrexate: Cases of serious toxicity have been reported when Methotrexate and NSAIDs are given within 24 hours of each other. Quinolone antimicrobials: Convulsions may occur due to an interaction between quinolones and NSAIDs. Therefore, caution should be exercised when considering concomitant therapy of NSAIDs and quinolones. Other NSAIDs and steroids: Co-administration of Diclofenac with other systemic NSAIDs and steroids may increase the frequency of unwanted effects. With Aspirin, the plasma levels of each are lowered, although no clinical significance is known. Diuretics: Various NSAIDs are liable to inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels. So, serum potassium should be monitored.
Contraindications
It is contraindicated for those patients who are hypersensitive to Diclofenac. In patients with active or suspected peptic ulcer or gastrointestinal bleeding or for those patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by Aspirin or other NSAIDs possessing prostaglandin synthetase inhibiting activity Diclofenac is also contraindicated. Because of the presence of Lidocaine, this injection is also contraindicated for those patients who are hypersensitive to local anaesthetics of the amide type, although the incidence is very rare. In patients with Adams-Stokes syndrome or with severe degrees of SA, AV, or intraventricular heart block in the absence of an artificial pacemaker, and for those patients who are hypersensitive to any of the excipients used in the formulation (Sodium Metabisulphite, Disodium Edetate, Benzyl Alcohol, Sodium Hydroxide, Propylene Glycol), this injection is also contraindicated.
Side Effects of Intafenac Plus (75 mg+20 mg)/2 ml
Side effects to Diclofenac Sodium and Lidocaine injection are usually mild and transient. However if serious side effects occur the injection should be discontinued. Gastrointestinal discomfort, nausea, diarrhea and occasionally bleeding may occur. In very rare instances, injection site disorder may occur. In isolated cases, abscesses and local necrosis may occur. The adverse effects due to Lidocaine mainly involve the CNS, are usually of short duration, and are dose related. The CNS reactions may be manifested by drowsiness, dizziness, disorientation, confusion, lightheadedness etc.
Pregnancy & Lactation
Use in Pregnancy: It should not be prescribed during pregnancy, unless there are compelling reasons for doing so. The lowest effective dosage should be used. These types of drugs are not recommended during the last trimester of pregnancy. Use in Lactation: Very small quantities of Diclofenac may be detected in breast milk, but no undesirable effects on the infant are to be expected.
Precautions & Warnings
Renal: Patients with severe hepatic, cardiac or renal insufficiency or the elderly should be kept under close observation, since the use of NSAIDs may result in deterioration of renal function. The lowest effective dose should be used and renal function should be monitored. Hepatic: If abnormal liver function tests persist or worsen, clinical signs or symptoms consistent with liver disease develop or if other manifestations occur (eosinophilia, rash), Diclofenac should be discontinued. All patients who are receiving long term treatment with NSAIDs should be monitored as a precautionary measure (e.g., renal, hepatic function and blood counts).
Overdose Effects of Intafenac Plus (75 mg+20 mg)/2 ml
Symptoms following acute NSAIDs overdoses are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs, and may occur following an overdose
Storage Conditions
Store at temparature not exceeding 30°C in a dry place. Protected from light.
Drug Classes
Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Mode Of Action
Diclofenac Sodium is a potent nonsteroidal antiinflammatory drug (NSAID) with marked analgesic and antipyretic properties. It also has some uricosuric effects. The action of Diclofenac appeared to be associated with the inhibition of prostaglandin synthesis. Diclofenac may inhibit synthesis of prostaglandins by inhibiting cyclooxygenase, an enzyme that catalyses the formation of prostaglandin precursors from arachidonic acid. Peak plasma concentration is achieved within half an hour following injection. Lidocaine is the most widely used local anaesthetic drug. It acts more rapidly and is more stable than most other local anaesthetics. It is a very useful surface anaesthetic. Like other local anaesthetics, Lidocaine impairs the generation and conduction of nerve impulses by slowing depolarization. The onset of anaesthesia of Lidocaine Hydrochloride is more rapid and the duration is 1-2 hours.
Pregnancy
It should not be prescribed during pregnancy unless there are compelling reasons for doing so. The lowest effective dosage should be used. These types of drugs are not recommended during the last trimester of pregnancy. Very small quantities of Diclofenac may be detected in breast milk, but no undesirable effects on the infant are to be expected.
Frequently Asked Questions
What is Intafenac Plus (75 mg+20 mg)/2 ml used for?
The injection contains Diclofenac Sodium that is used to relief all grades of pain and inflammation in a wide range of conditions including: Arthritic conditions such as rheumatoid arthritis, osteoarthritis, juvenile chronic arthritis, ankylosing spondylitis, acute gout. Acute musculoskeletal disorders such as periarthritis (e.g., Frozen shoulder), tendinitis, tenosynovitis, bursitis. ... Read mor…
What is the dosage of Intafenac Plus (75 mg+20 mg)/2 ml?
Adult: One ampoule once (or in severe cases, twice) daily by intramuscular injection.Renal colic: One ampoule once daily intramuscularly. A second dose may be administered after 30 minutes if necessary.Children: In Juvenile chronic arthritis, 1-3 mg of Diclofenac Sodium per kg body weight daily in divided doses.Elderly patients: In elderly or debilitated patients, the lowest effective dosage is re…
What are the side effects of Intafenac Plus (75 mg+20 mg)/2 ml?
Side effects to Diclofenac Sodium and Lidocaine injection are usually mild and transient. However if serious side effects occur the injection should be discontinued. Gastrointestinal discomfort, nausea, diarrhea and occasionally bleeding may occur. In very rare instances, injection site disorder may occur. In isolated cases, abscesses and local necrosis may occur. The adverse effects due to Lidoca…
Who should not take Intafenac Plus (75 mg+20 mg)/2 ml?
It is contraindicated for those patients who are hypersensitive to Diclofenac. In patients with active or suspected peptic ulcer or gastrointestinal bleeding or for those patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by Aspirin or other NSAIDs possessing prostaglandin synthetase inhibiting activity Diclofenac is also contraindicated. Because of the presence of Li…
What precautions should be taken with Intafenac Plus (75 mg+20 mg)/2 ml?
Renal: Patients with severe hepatic, cardiac or renal insufficiency or the elderly should be kept under close observation, since the use of NSAIDs may result in deterioration of renal function. The lowest effective dose should be used and renal function should be monitored. Hepatic: If abnormal liver function tests persist or worsen, clinical signs or symptoms consistent with liver disease develop…
Is Intafenac Plus (75 mg+20 mg)/2 ml safe during pregnancy and breastfeeding?
Use in Pregnancy: It should not be prescribed during pregnancy, unless there are compelling reasons for doing so. The lowest effective dosage should be used. These types of drugs are not recommended during the last trimester of pregnancy. Use in Lactation: Very small quantities of Diclofenac may be detected in breast milk, but no undesirable effects on the infant are to be expected.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.