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Nintoin100 mg
Incepta Pharmaceuticals Ltd.
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Ofuran SR100 mg
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Medicine overview
Indications of Ofuran SR 100 mg
EnterococciStaphylococcus aureusStaphylococcus saprophyticus and certain susceptible strains of Klebsiella and Enterobacter species.
Theropeutic Class
Systemic Urinary Anti- infective
Pharmacology
Ofuran SR 100 mg interferes with cell metabolism and cell wall synthesis by inhibiting several enzyme systems including acetyl coenzyme A.
Excretion
It is bactericidal to most gram-positive and gram-negative urinary tract pathogens.
Dosage of Ofuran SR 100 mg
Ofuran SR 100 mg tablet (In adults)
Dosage:Uncomplicated urinary tract infections: 50-100 mg four times a day- the lower dosage level is recommended
Notes:Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained
For long-term suppressive therapy
Dosage:In adults, a reduction of dosage to 50-100 mg at bedtime may be adequate
Ofuran SR 100 mg capsule (In adults)
Dosage:Acute Uncomplicated Urinary Tract Infections (UTIs): 50 mg four times daily for 7 days
Long term suppression
Dosage:50-100 mg once a day
Prophylaxis
Dosage:50 mg four times daily for the duration of procedure and for three days thereafter
Ofuran SR 100 mg SR capsule
Dosage:Adults and Children over 12 years: One 100 mg capsule every 12 hours for seven days
Genito-urinary surgical prophylaxis
Dosage:One capsule twice daily on day of procedure and for next 3 days
Ofuran SR 100 mg suspension
Dosage:Children: 5-7 mg/kg/day in four divided doses (contraindicated under one month of age)
Notes:The average dose of Nintoin suspension for pediatric patients are as follows- 7 to 11 kg: ½ (2.5 ml) teaspoonfuls 4 times daily. 12 to 21 kg: 1 (5 ml) teaspoonfuls 4 times daily. 22 to 30 kg: 1½ (7.5 ml) teaspoonfuls 4 times daily. 31 to 41 kg: 2 (10 ml) teaspoonfuls 4 times daily. Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained. For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate
| Condition | Dosage | Notes |
|---|---|---|
| Ofuran SR 100 mg tablet (In adults) | Uncomplicated urinary tract infections: 50-100 mg four times a day- the lower dosage level is recommended | Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained |
| For long-term suppressive therapy | In adults, a reduction of dosage to 50-100 mg at bedtime may be adequate | |
| Ofuran SR 100 mg capsule (In adults) | Acute Uncomplicated Urinary Tract Infections (UTIs): 50 mg four times daily for 7 days | |
| Long term suppression | 50-100 mg once a day | |
| Prophylaxis | 50 mg four times daily for the duration of procedure and for three days thereafter | |
| Ofuran SR 100 mg SR capsule | Adults and Children over 12 years: One 100 mg capsule every 12 hours for seven days | |
| Genito-urinary surgical prophylaxis | One capsule twice daily on day of procedure and for next 3 days | |
| Ofuran SR 100 mg suspension | Children: 5-7 mg/kg/day in four divided doses (contraindicated under one month of age) | The average dose of Nintoin suspension for pediatric patients are as follows- 7 to 11 kg: ½ (2.5 ml) teaspoonfuls 4 times daily. 12 to 21 kg: 1 (5 ml) teaspoonfuls 4 times daily. 22 to 30 kg: 1½ (7.5 ml) teaspoonfuls 4 times daily. 31 to 41 kg: 2 (10 ml) teaspoonfuls 4 times daily. Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained. For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate |
Administration of Ofuran SR 100 mg
Ofuran SR 100 mg should be taken with food.
Interaction of Ofuran SR 100 mg
Antacids containing Magnesium Trisilicate, when administered concomitantly with Ofuran SR 100 mg, reduce both the rate and extent of absorption of Uricosuric drugs, such as Probenecid and Sulfinpyrazone, can inhibit renal tubular secretion of Ofuran SR 100 mg.
Contraindications
Anuria, oliguria or significant impairment of renal function are contraindications. This drug is contraindicated in pregnant patients at 38-42 weeks, during labor and delivery. Ofuran SR 100 mg is also contraindicated in those patients with known hypersensitivity to Ofuran SR 100 mg.
Side Effects of Ofuran SR 100 mg
The most frequent clinical adverse events are nausea, headache, and flatulence. Other less occurred adverse events are diarrhea, dyspepsia, abdominal pain, constipation, emesis, dizziness and drowsiness.
Pregnancy & Lactation
Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed.Ofuran SR 100 mg has been detected in human breast milk in trace amounts. Because of the potential for serious adverse reactions from Ofuran SR 100 mg in nursing infants under one month of age, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Precautions & Warnings
If acute, sub-acute or chronic pulmonary reactions occur, Ofuran SR 100 mg should be discontinued. Antacid preparations containing magnesium trisilicate should not be taken while taking Ofuran SR 100 mg.
Overdose Effects of Ofuran SR 100 mg
Occasional incidents of acute overdosage of Ofuran SR 100 mg have not resulted in any specific symptoms other than vomiting. Induction of emesis is recommended.
Storage Conditions
Do not store above 30°C. Keep away from light and out of the reach of children.
Drug Classes
Systemic Urinary Anti- infective
Mode Of Action
Ofuran SR 100 mg is an antibacterial agent specific for urinary tract infections. Ofuran SR 100 mg is highly soluble in urine, to which it may impart a brown color. Ofuran SR 100 mg inactivates or alters bacterial ribosomal proteins and other macromolecules. Ofuran SR 100 mg has been shown to be active against the following bacteria: Gram-Positive Aerobes Staphylococcus saprophyticus, Coagulase-negative staphylococci (including Staphylococcus epidermidis), Enterococcus faecalis, Staphylococcus aureus, Streptococcus agalactiae, Group D streptococci, Viridans group streptococci. Gram-Negative Aerobes- Escherichia coli, Citrobacter amalonaticus, Citrobacter diversus, Citrobacter freundii, Klebsiella oxytoca, Klebsiella ozaenae.
Pregnancy
Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Ofuran SR 100 mg has been detected in human breast milk in trace amounts. Because of the potential for serious adverse reactions from Ofuran SR 100 mg in nursing infants under one month of age, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
What is Ofuran SR 100 mg used for?
Nitrofurantoin is specifically indicated for the treatment & prophylaxis of urinary tract infections caused by susceptible strains of Escherichia coli, Enterococci, Staphylococcus aureus, Staphylococcus saprophyticus and certain susceptible strains of Klebsiella and Enterobacter species.
What is the dosage of Ofuran SR 100 mg?
Nitrofurantoin tablet (In adults): Uncomplicated urinary tract infections: 50-100 mg four times a day- the lower dosage level is recommended. Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained. For long-term suppressive therapy: In adults, a reduction of dosage to 50-100 mg at bedtime may be adequate. Nitrofurantoin capsule (In adults): Acute U…
What are the side effects of Ofuran SR 100 mg?
The most frequent clinical adverse events are nausea, headache, and flatulence. Other less occurred adverse events are diarrhea, dyspepsia, abdominal pain, constipation, emesis, dizziness and drowsiness.
Who should not take Ofuran SR 100 mg?
Anuria, oliguria or significant impairment of renal function are contraindications. This drug is contraindicated in pregnant patients at 38-42 weeks, during labor and delivery. Nitrofurantoin is also contraindicated in those patients with known hypersensitivity to Nitrofurantoin.
What precautions should be taken with Ofuran SR 100 mg?
If acute, sub-acute or chronic pulmonary reactions occur, Nitrofurantoin should be discontinued. Antacid preparations containing magnesium trisilicate should not be taken while taking Nitrofurantoin.
Is Ofuran SR 100 mg safe during pregnancy and breastfeeding?
Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed.Nitrofurantoin has been detected in human breast milk in trace amounts. Because of the potential for serious adverse reactions from Nitrofurantoin in nursing infants under one month of age, a decision should be made whether to discontinue nursi…
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.