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Xynovir300 mg
Incepta Pharmaceuticals Ltd.
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Medicine overview
Indications of Proxivir 300 mg
This is indicated for the treatment of:
Chronic hepatitis B virus infection in adults
HIV infected adults in combination with other anti retroviral agents
Theropeutic Class
Drugs for HIV / Anti-retroviral drugs, Hepatic viral infections (Hepatitis B)
Pharmacology
Proxivir 300 mg, an acyclic nucleotide analogue of adenosine monophosphate, is a pro-drug of Tenofovir. It shows activity against hepatitis B virus polymerase and HIV reverse transcriptase after phosphorylation to the active diphosphate form. Tenofovir diphosphate inhibits viral polymerase (reverse transcriptase) by directly competing with the natural substrate deoxyribonucleotide and by causing DNA chain termination after its incorporation into viral DNA.
Dosage & Administration of Proxivir 300 mg
The recommended dose of Tenofovir in chronic hepatitis B virus infection in adults 18 years of age and older with adequate renal function is 300 mg once daily with or without food.
Interaction of Proxivir 300 mg
Co-administration of Tenofovir with anti-retroviral, entecavir, lamivudine, methadone, oral contraceptives, ribavirin and tacrolimus did not result in significant drug interactions. The effects of co-administration of Tenofovir with other drugs that are renally eliminated or are known to affect renal function have not been evaluated.
Contraindications
Tenofovir is contraindicated in patients with known hypersensitivity to Tenofovir or any component of the product.
Side Effects of Proxivir 300 mg
The most common side effects are nausea, vomiting, diarrhea and flatulence.
Pregnancy & Lactation
Pregnancy: Pregnancy category B. It should be used during pregnancy only if clearly needed.Lactation: It is not known whether it is excreted in human milk. Mothers should be instructed not to breast feed if they are taking Tenofovir.
Precautions & Warnings
Co-administration with other drugs: Tenofovir should not be administered concurrently with Emtricitabine & Tenofovir combination or Adefovir Dipivoxil.Lactic Acidosis & Severe Hepatomegaly with Steatosis: Though the risk of occurrence of lactic acidosis is low for Tenofovir, treatment should be suspended in any patient who develops lactic acidosis or hepatotoxicity. Exacerbation of hepatitis after discontinuation of treatment: Discontinuation of Tenofovirtherapy may be associated with severe acute exacerbation of hepatitis.
Overdose Effects of Proxivir 300 mg
There is no experience of Tenofovir overdose reported in patients
Storage Conditions
Store in a cool and dry place, protected from light and moisture. Keep the medicine out of the reach of children.
Use In Special Populations
Pediatric use: Safety and effectiveness of Tenofovir in pediatric patients below the age of 18 years have not been established.Geriatrics use: Clinical studies of Tenofovir did not include sufficient numbers of subjects aged 65 years and over to determine whether they respond differently from younger subjects. But care should be taken in dose selection, and it may be useful to monitor renal function.Renal Impairment: Haemodialysis patients: 300 mg once every 7 days or after a cumulative total of 12 hr of dialysis.
CrCl (10-29 mL/min): 300 mg 72-96 hrly.
CrCl (30-49 mL/min): 300 mg 48 hrly.
Hepatic impairment: No dose adjustment is required in patients with hepatic impairment.
Frequently Asked Questions
What is Proxivir 300 mg used for?
This is indicated for the treatment of: Chronic hepatitis B virus infection in adults HIV infected adults in combination with other anti retroviral agents
What is the dosage of Proxivir 300 mg?
The recommended dose of Tenofovir in chronic hepatitis B virus infection in adults 18 years of age and older with adequate renal function is 300 mg once daily with or without food.
What are the side effects of Proxivir 300 mg?
The most common side effects are nausea, vomiting, diarrhea and flatulence.
Who should not take Proxivir 300 mg?
Tenofovir is contraindicated in patients with known hypersensitivity to Tenofovir or any component of the product.
What precautions should be taken with Proxivir 300 mg?
Co-administration with other drugs: Tenofovir should not be administered concurrently with Emtricitabine & Tenofovir combination or Adefovir Dipivoxil.Lactic Acidosis & Severe Hepatomegaly with Steatosis: Though the risk of occurrence of lactic acidosis is low for Tenofovir, treatment should be suspended in any patient who develops lactic acidosis or hepatotoxicity. Exacerbation of hepatitis after…
Is Proxivir 300 mg safe during pregnancy and breastfeeding?
Pregnancy: Pregnancy category B. It should be used during pregnancy only if clearly needed.Lactation: It is not known whether it is excreted in human milk. Mothers should be instructed not to breast feed if they are taking Tenofovir.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.