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Suvotol

Suvotol10 mg

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Medicine overview

Indications of Suvotol 10 mg

Suvotol 10 mg is indicated for the treatment of insomniacharacterized by difculties with sleep onset and/or sleep maintenance.

Theropeutic Class

Miscellaneous sedatives & hypnotics

Pharmacology

Suvotol 10 mg is a highly selective antagonist for orexin receptors OX1R and OX2R.

Absorption

The mechanism by which Suvotol 10 mg exerts its therapeutic efect in insomnia is presumed to be through antagonism of orexin receptors.

Distribution

The orexin neuropeptide signaling system is a central promoter of wakefulness.

Metabolism

Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive.

Dosage & Administration of Suvotol 10 mg

Recommended dose is 10 mg, no more than once per night taken before 30 minutes of going to bed, with at least 7 hours remaining before the planned time of awakening. If the 10 mg dose is well-tolerated but not effective, the dose can be increased, not to exceed 20 mg once daily. Lowest dose effective should be used for the patient. Time to effect may be delayed if taken with or soon after a meal.

Dosage of Suvotol 10 mg

Recommended dose is 10 mg, no more than once per night taken before 30 minutes of going to bed, with at least 7 hours remaining before the planned time of awakening. If the 10 mg dose is well-tolerated but not effective, the dose can be increased, not to exceed 20 mg once daily. Lowest dose effective should be used for the patient. Time to effect may be delayed if taken with or soon after a meal.

Interaction of Suvotol 10 mg

CNS-Active Drugs: An additive effect on psychomotor performance was observed when a single dose of 40 mg of Suvotol 10 mg was co-administered with a single dose of 0.7 g/kg alcohol. Suvotol 10 mg does not afect alcohol concentrations and alcohol does not afect Suvotol 10 mg concentrations.effect s of Other Drugs on Suvotol 10 mg: Strong (e.g., ketoconazole or itraconazole) and moderate (e.g., diltiazem) CYP3A inhibitors signifcantly increased Suvotol 10 mg exposure. Strong CYP3A inducers (e.g., rifampin) substantially decreases Suvotol 10 mg exposure.effect s of Suvotol 10 mg on Other Drugs: Suvotol 10 mg is unlikely to cause clinically signifcant inhibition of human CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 or CYP2D6. Chronic administration of Suvotol 10 mg is unlikely to induce the metabolism of drugs metabolized by major CYP isoforms.

Contraindications

Do not use in patients with narcolepsy.

Side Effects of Suvotol 10 mg

Common side effects are Sleepiness during the day, Not thinking clearly, Act strangely, confused, or upset, Sleep-walking

Pregnancy & Lactation

Pregnancy Category C. There is no adequate and well-controlled studies in pregnant women. Suvotol 10 mg should be used during pregnancy only if the potential beneft justifes the potential risk to the fetus.

Precautions & Warnings

Daytime somnolence: Risk of impaired alertness and motor coordination, including impaired driving; risk increases with dose; caution patients taking 20 mg against next-day driving and other activities requiring complete mental alertness. Need to evaluate for co-morbid diagnoses: Reevaluate if insomnia persists after 7 to 10 days of treatment.

Storage Conditions

Store in dry and cool place, protect from light & keep away from children.

Drug Classes

Miscellaneous sedatives & hypnotics

Mode Of Action

Suvotol 10 mg is a highly selective antagonist for orexin receptors OX1R and OX2R. The mechanism by which Suvotol 10 mg exerts its therapeutic efect in insomnia is presumed to be through antagonism of orexin receptors. The orexin neuropeptide signaling system is a central promoter of wakefulness. Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive.

Pregnancy

Pregnancy Category C. There is no adequate and well-controlled studies in pregnant women. Suvotol 10 mg should be used during pregnancy only if the potential beneft justifes the potential risk to the fetus.

Frequently Asked Questions

What is Suvotol 10 mg used for?

Suvorexant is indicated for the treatment of insomnia, characterized by difculties with sleep onset and/or sleep maintenance.

What is the dosage of Suvotol 10 mg?

Recommended dose is 10 mg, no more than once per night taken before 30 minutes of going to bed, with at least 7 hours remaining before the planned time of awakening. If the 10 mg dose is well-tolerated but not effective, the dose can be increased, not to exceed 20 mg once daily. Lowest dose effective should be used for the patient. Time to effect may be delayed if taken with or soon after a meal.

What are the side effects of Suvotol 10 mg?

Common side effects are Sleepiness during the day, Not thinking clearly, Act strangely, confused, or upset, Sleep-walking

Who should not take Suvotol 10 mg?

Do not use in patients with narcolepsy.

What precautions should be taken with Suvotol 10 mg?

Daytime somnolence: Risk of impaired alertness and motor coordination, including impaired driving; risk increases with dose; caution patients taking 20 mg against next-day driving and other activities requiring complete mental alertness. Need to evaluate for co-morbid diagnoses: Reevaluate if insomnia persists after 7 to 10 days of treatment.

Is Suvotol 10 mg safe during pregnancy and breastfeeding?

Pregnancy Category C. There is no adequate and well-controlled studies in pregnant women. Suvorexant should be used during pregnancy only if the potential beneft justifes the potential risk to the fetus.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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