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Tensicon0.5 mg+10 mg
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Medicine overview
Indications of Tensicon 0.5 mg+10 mg
Tensicon 0.5 mg+10 mg tablet is indicated in- Anxiety Depression Apathy Psychogenic depression. Depressive neurosses. Masked depression. Psychosomatic affections accompanied by anxiety and apathy. Menopausal depressions. Dysphoria and depression in alcoholics and drug addicts.
Theropeutic Class
Combined anxiolytics & anti-depressant drugs
Pharmacology
Maximum serum concentration is reached in about 4 hours after oral administration of Tensicon 0.5 mg+10 mg.
Absorption
The combination of Flupentixol and Melitracen does not seem to influence the pharmacokinetic properties of the individual compounds. Flupenthixol primarily acts as a neuroleptic drug.
Distribution
The antipsychotic effect of Flupenthixol is achieved by mixed blockade of dopamine D1 and D2 receptors. In the mesolimbic dopamine system of the brain, this accounts for the antipsychotic action of this drug.
Metabolism
The half-life of Flupentixol is about 35 hours and that of Melitracen is about 19 hours.
Excretion
Melitracen is a tricyclic antidepressant. It blocks the neuronal re-uptake of both serotonin and nor-epinephrine in the central nervous system, there by minimizing the symptoms of depression.
Dosage & Administration of Tensicon 0.5 mg+10 mg
Adults
Dosage:Usually 2 tablets daily, in morning and afternoon
Notes:In severe cases, the morning dose may be increased to 2 tablets
Elderly patients
Dosage:1 tablet in the morning
Maintenance dose
Dosage:Usually 1 tablet in the morning or as directed by the physician
| Condition | Dosage | Notes |
|---|---|---|
| Adults | Usually 2 tablets daily, in morning and afternoon | In severe cases, the morning dose may be increased to 2 tablets |
| Elderly patients | 1 tablet in the morning | |
| Maintenance dose | Usually 1 tablet in the morning or as directed by the physician |
Dosage of Tensicon 0.5 mg+10 mg
Adults
Dosage:Usually 2 tablets orally daily in the morning and noon
Notes:In severe cases, the morning dose may be increased to 2 tablets
Elderly patients
Dosage:1 tablet in the morning
Maintenance dose
Dosage:Usually 1 tablet orally in the morning
Notes:In cases of insomnia or severe restlessness, additional treatment with a sedative in the acute phase is recommended
| Condition | Dosage | Notes |
|---|---|---|
| Adults | Usually 2 tablets orally daily in the morning and noon | In severe cases, the morning dose may be increased to 2 tablets |
| Elderly patients | 1 tablet in the morning | |
| Maintenance dose | Usually 1 tablet orally in the morning | In cases of insomnia or severe restlessness, additional treatment with a sedative in the acute phase is recommended |
Interaction of Tensicon 0.5 mg+10 mg
This tablet may enhance the response to alcohol, barbiturates and other CNS depressants. Simultaneous administration of MAO-inhibitors may cause hypertensive crises. Neuroleptics and thymoleptics reduce the antihypertensive effect of guanethidine and similar acting compounds and thymoleptics enhance the effects of adrenaline and noradrenaline.
Contraindications
The immediate recovery phase after myocardial infarction. Defects in bundle-branch conduction. Untreated narrow-angle glaucoma. Acute alcohol, barbiturate and opiate intoxications. This tablet should not be given to patients who have received an MAO-inhibitor within two weeks. Not recommended for excitable or overactive patients since its activating effect may lead to exaggeration of these characteristics.
Side Effects of Tensicon 0.5 mg+10 mg
In the recommended doses side effects are rare. These could be transient restlessness and insomnia.
Pregnancy & Lactation
The safety of this drug has not been established in pregnancy and lactation.
Precautions & Warnings
If previously the patient has been treated with tranquillizers with sedative effect these should be withdrawn gradually.
Overdose Effects of Tensicon 0.5 mg+10 mg
In cases of overdosage the symptoms of intoxications by melitracen, especially of anticholinergic nature, dominate. More rarely extrapyramidal symptoms due to flupentixol occur. Symptomatic and Supportive. Gastric lavage should be carried out as soon as possible and activated charcoal may be administered. Measures aimed at supporting the respiratory and cardiovascular systems should be instituted. Epinephrine (adrenaline) must not be used for such patients. Convulsions may be treated with diazepam and extrapyramidal symptoms with biperiden.
Storage Conditions
Store at a temperature not exceeding 30°C in a dry place. Protect from light. Keep out of reach of children.
Drug Classes
Combined anxiolytics & anti-depressant drugs
Mode Of Action
This consists of two well known and well proven compounds: flupentixol-a neuroleptic with anxiolytic and antidepressant properties of its own when given in small doses, and melitracen-a bipolar thymoleptic with activating properties in low doses. In combination the compounds render a preparation with antidepressant, anxiolytic and activating properties. Maximal serum concentration is reached in about 4 hours after oral administration of flupentixol and in about 4 hours after oral administration of melitracen. The biological half-life of flupentixol is about 35 hours and that of melitracen is about 19 hours. The combination of Tensicon 0.5 mg+10 mg does not seem to influence the pharmacokinetic properties of the individual compounds.
Pregnancy
This tablet should preferably not be given during pregnancy and lactation.
Frequently Asked Questions
What is Tensicon 0.5 mg+10 mg used for?
Flupentixol + Melitracen tablet is indicated in- Anxiety Depression Apathy Psychogenic depression. Depressive neurosses. Masked depression. Psychosomatic affections accompanied by anxiety and apathy. Menopausal depressions. Dysphoria and depression in alcoholics and drug addicts.
What is the dosage of Tensicon 0.5 mg+10 mg?
Adults: Usually 2 tablets orally daily in the morning and noon. In severe cases, the morning dose may be increased to 2 tablets.Elderly patients: 1 tablet in the morning. Maintenance dose: Usually 1 tablet orally in the morning. In cases of insomnia or severe restlessness, additional treatment with a sedative in the acute phase is recommended.
What are the side effects of Tensicon 0.5 mg+10 mg?
In the recommended doses side effects are rare. These could be transient restlessness and insomnia.
Who should not take Tensicon 0.5 mg+10 mg?
The immediate recovery phase after myocardial infarction. Defects in bundle-branch conduction. Untreated narrow-angle glaucoma. Acute alcohol, barbiturate and opiate intoxications. This tablet should not be given to patients who have received an MAO-inhibitor within two weeks. Not recommended for excitable or overactive patients since its activating effect may lead to exaggeration of these charact…
What precautions should be taken with Tensicon 0.5 mg+10 mg?
If previously the patient has been treated with tranquillizers with sedative effect these should be withdrawn gradually.
Is Tensicon 0.5 mg+10 mg safe during pregnancy and breastfeeding?
The safety of this drug has not been established in pregnancy and lactation.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.