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Cabergol0.5 mg
Popular Pharmaceuticals Ltd.
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Generic medicine
Cabergoline: Brands, Price & Uses in Bangladesh
Cabergoline is a dopamine receptor agonist used mainly to lower elevated blood prolactin levels and, in some clinical settings, to suppress breast milk production.
About Cabergoline
Indications of Cabergoline
Cabergoline is a dopamine receptor agonist used mainly to lower elevated blood prolactin levels and, in some clinical settings, to suppress breast milk production.
Established/Approved Uses
- Hyperprolactinemic disorders — treatment of high prolactin levels that are idiopathic or caused by prolactin-secreting pituitary tumors (prolactinomas), whether microadenomas or macroadenomas. This is the primary regulatory-approved indication for Cabergoline.
Other Established Uses (widely used in clinical practice)
- Prevention or suppression of physiological (postpartum) lactation — Cabergoline is used in many countries, including Bangladesh, to prevent breast engorgement when breastfeeding is not intended, or to stop already-established lactation, always under physician supervision.
Guideline-Supported / Adjunct Uses
- As part of the management of infertility associated with hyperprolactinemia, to restore ovulatory menstrual cycles, once other causes have been excluded.
Off-Label Use (not FDA-approved, used selectively by specialists)
- Adjunctive use in mild Parkinson's disease at higher doses in some countries, but this use is limited by the increased risk of cardiac valve disease at higher doses and is not the basis for the Bangladesh-marketed low-dose (0.5 mg/1 mg) formulations.
The exact indication and dosing must be confirmed and supervised by a physician.
Dosage & Administration of Cabergoline
Hyperprolactinemic Disorders (Adults)
| Step | Dose of Cabergoline | Notes |
|---|---|---|
| Starting dose | 0.25 mg twice weekly (e.g., Monday and Thursday) | Taken orally, preferably with food |
| Titration | Increase by 0.25 mg twice weekly, at intervals of no less than 4 weeks | Guided by serum prolactin levels and tolerability |
| Usual maintenance dose | Up to 1 mg twice weekly (some patients may need higher doses under specialist supervision) | Use the lowest effective dose |
| Reassessment | After prolactin is normal for about 6 months, a physician may consider a trial discontinuation with periodic monitoring | Prolactin should be re-checked periodically after stopping |
Prevention of Physiological (Postpartum) Lactation
A single dose of 1 mg of Cabergoline given once, on the first day after delivery, as advised by the physician.
Suppression of Already-Established Lactation
0.25 mg of Cabergoline every 12 hours for 2 days (total 4 doses), as advised by the physician.
General Administration Notes
- Take Cabergoline exactly as prescribed; do not increase, decrease, or stop the dose without consulting the physician.
- Take with food to reduce nausea.
- A baseline cardiovascular evaluation, including echocardiogram, is recommended before starting long-term therapy, with periodic echocardiographic monitoring during prolonged treatment (see Precautions).
Side Effects of Cabergoline
Common Side Effects
| Side Effect | Approximate Frequency |
|---|---|
| Nausea | Common (up to ~1 in 4 patients) |
| Headache | Common |
| Dizziness / vertigo | Common |
| Constipation | Common |
| Orthostatic hypotension (light-headedness on standing) | Common, especially with the first doses |
| Fatigue, breast pain, hot flushes | Less common |
Less Common but Serious Side Effects
- Cardiac valve disease (valvulopathy) — see Precautions and Warnings.
- Fibrotic reactions affecting the lungs, heart lining (pericardium), or the area behind the abdomen (retroperitoneum).
- Impulse control disorders such as compulsive gambling, hypersexuality, or compulsive shopping/eating.
- Psychiatric disturbances, including worsening of pre-existing psychosis.
- Fainting (syncope), due to low blood pressure.
- Hair thinning (alopecia).
Patients should promptly report any unusual symptoms — such as shortness of breath, swelling of the ankles/legs, chest pain, unusual urges/behaviors, or fainting — to their physician while taking Cabergoline.
Contraindications of Cabergoline
Cabergoline is contraindicated in patients with:
- Known hypersensitivity to Cabergoline, other ergot alkaloids, or any component of the formulation.
- Uncontrolled hypertension.
- Pregnancy-induced hypertensive disorders, including pre-eclampsia and post-partum hypertension (unless the potential benefit clearly outweighs the risk, per specialist judgment).
- A history of cardiac valvular disorders, as evidenced by echocardiographic findings of valve regurgitation, valve leaflet thickening, or restriction.
- A history of pulmonary, pericardial, or retroperitoneal fibrotic disorders.
Frequently Asked Questions about Cabergoline
What is Cabergoline used for?
Cabergoline is mainly used to lower high blood prolactin levels caused by conditions such as prolactin-secreting pituitary tumors, and it is also used to prevent or stop breast milk production after childbirth when breastfeeding is not intended, under a physician's guidance.
How is Cabergoline usually taken?
Cabergoline is taken by mouth, generally with food to reduce nausea. For high prolactin levels it is usually taken twice a week at a low starting dose that may be gradually increased by the physician. For stopping breast milk production, it may be given as a single dose or a short 2-day course. Always follow the physician's specific instructions.
Who should not take Cabergoline?
Cabergoline should not be used by people who are allergic to it or to other ergot-type medicines, those with uncontrolled high blood pressure, those with pregnancy-related high blood pressure disorders (such as pre-eclampsia) unless a specialist advises otherwise, or those with a known history of heart valve disease or fibrotic (scarring) conditions of the lungs, heart lining, or abdomen.
What are the most important side effects to watch for with Cabergoline?
Common side effects of Cabergoline include nausea, headache, dizziness, and light-headedness on standing up. More serious but less common effects include heart valve problems, fibrotic reactions, unusual urges or compulsive behaviors (such as gambling), and fainting. Report any new shortness of breath, swelling, chest pain, or unusual behavior changes to a physician promptly.
Can Cabergoline be used during pregnancy or breastfeeding?
Cabergoline should be used in pregnancy only if clearly needed and if the potential benefit outweighs the possible risk to the baby, and it is contraindicated in pregnancy-related high blood pressure disorders unless a specialist decides otherwise. Because it lowers milk production, it is not used by mothers who wish to breastfeed, except when a physician specifically prescribes it to stop lactation. Always consult a physician before use in pregnancy or while breastfeeding.
What should I do if I miss a dose or take too much Cabergoline?
If a dose of Cabergoline is missed, contact the physician for advice rather than doubling the next dose. If an overdose is suspected, symptoms such as nasal congestion, fainting, or hallucinations may occur; seek immediate medical attention or contact emergency services/a poison control center right away rather than attempting home treatment.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.