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Hyoscine Hydrobromide: Brands, Price & Uses in Bangladesh
Hyoscine Hydrobromide is a belladonna-alkaloid antimuscarinic used in several clinical settings, with the strength of evidence varying by indication: Established / Approved Uses Prevention of nausea…
About Hyoscine Hydrobromide
Indications of Hyoscine Hydrobromide
Hyoscine Hydrobromide is a belladonna-alkaloid antimuscarinic used in several clinical settings, with the strength of evidence varying by indication:
Established / Approved Uses
- Prevention of nausea and vomiting due to motion sickness (transdermal patch, oral tablet formulations).
- Prevention of postoperative nausea and vomiting (PONV) following anesthesia and/or opioid analgesia (transdermal patch, adults).
- Pre-anesthetic medication to reduce salivary and respiratory tract secretions and to reduce the risk of vagally-mediated bradycardia during surgery (injection).
Guideline-Supported Clinical Use
- Management of excessive respiratory secretions ("death rattle") in terminally ill/palliative care patients - widely used and recommended in palliative care guidelines, administered by injection or transdermal patch.
Other Uses
- As a short-acting mydriatic/cycloplegic agent in ophthalmic examination (ophthalmic solution), used less commonly than other cycloplegics.
- Adjunct antispasmodic for gastrointestinal or genitourinary smooth-muscle spasm in some markets (tablet/injection); evidence is more limited than for hyoscine butylbromide.
A physician should confirm the specific indication and formulation appropriate for each patient.
Dosage & Administration of Hyoscine Hydrobromide
Dosing of Hyoscine Hydrobromide depends on the indication and formulation used; the following is a general guide and does not replace product-specific labeling or a physician's instructions.
| Indication | Formulation | Typical Adult Dose |
|---|---|---|
| Motion sickness prevention | Transdermal patch | One patch applied to hairless skin behind the ear at least 4 hours before travel; effective for up to 72 hours. |
| Motion sickness prevention | Oral tablet | Typically 300 mcg, 20-30 minutes before travel; may be repeated per product labeling up to a maximum daily dose. |
| Prevention of postoperative nausea/vomiting | Transdermal patch | One patch applied the evening before surgery, removed 24 hours after surgery. |
| Pre-anesthetic secretion reduction | Injection (IM/IV/SC) | Typically 200-600 mcg as a single pre-operative dose, per anesthesiologist's protocol. |
| Excessive respiratory secretions (palliative care) | Injection (SC/IV) or transdermal patch | Individualized by the palliative care/medical team, per local protocol. |
See Dosage and Administration for further detail, and Use in Special Populations for pediatric, elderly, and organ-impairment considerations.
Side Effects of Hyoscine Hydrobromide
Common side effects of Hyoscine Hydrobromide include:
- Dry mouth (most common)
- Drowsiness/somnolence
- Blurred vision and pupil dilation (mydriasis)
- Dizziness
- Application-site skin reactions (patch)
Less common but clinically important effects include tachycardia, urinary retention, constipation, confusion or agitation (particularly in the elderly), and rarely, hallucinations, psychosis, or hyperthermia (see Precautions and Warnings). Report severe or persistent side effects to a physician promptly.
Contraindications of Hyoscine Hydrobromide
Hyoscine Hydrobromide is contraindicated in patients with:
- Known hypersensitivity to hyoscine (scopolamine), other belladonna alkaloids, or any component of the formulation.
- Angle-closure (narrow-angle) glaucoma.
- Myasthenia gravis.
- Paralytic ileus, pyloric stenosis, or other mechanical gastrointestinal obstruction.
- Urinary retention or bladder outlet obstruction (e.g., due to prostatic hypertrophy).
Frequently Asked Questions about Hyoscine Hydrobromide
What is Hyoscine Hydrobromide used for?
Hyoscine Hydrobromide is mainly used to prevent nausea and vomiting caused by motion sickness and after surgery, to reduce saliva and airway secretions before anesthesia, and to manage excessive respiratory secretions in palliative/end-of-life care.
How is the Hyoscine Hydrobromide patch applied?
Apply one patch to a clean, dry, hairless area of skin behind the ear at least 4 hours before an antiemetic effect is needed. Do not cut the patch, and wash your hands thoroughly with soap and water immediately after applying or removing it, since accidental contact with the eyes can cause pupil dilation and blurred vision.
Can Hyoscine Hydrobromide be used during pregnancy or breastfeeding?
Hyoscine Hydrobromide should be used in pregnancy only if clearly needed, since data are limited and it crosses the placenta; it should generally be avoided in women with severe pre-eclampsia. It also passes into breast milk, so a physician should be consulted to weigh the benefits and risks before use while breastfeeding.
Who should not use Hyoscine Hydrobromide?
Hyoscine Hydrobromide should not be used by people with a known hypersensitivity to it or other belladonna alkaloids, angle-closure glaucoma, myasthenia gravis, paralytic ileus or other gastrointestinal obstruction, or urinary retention/bladder outlet obstruction.
What are the common side effects of Hyoscine Hydrobromide?
The most common side effects are dry mouth, drowsiness, blurred vision, dilated pupils, and dizziness. Less commonly, it can cause confusion, agitation, tachycardia, constipation, or urinary retention, particularly in elderly patients.
What should I do if someone takes too much Hyoscine Hydrobromide?
An overdose can cause confusion, hallucinations, a fast heartbeat, hot dry skin, and fever. If overdose is suspected, seek immediate medical attention or contact emergency services or a poison control center right away; do not try to treat it at home.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.