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Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B: Brands, Price & Uses in Bangladesh
Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B is a combination vaginal anti-infective product indicated for the local (intravaginal) treatment of mixed vaginal infections and more.
About Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B
Indications of Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B
Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B is a combination vaginal anti-infective product indicated for the local (intravaginal) treatment of mixed vaginal infections, where more than one type of organism is responsible for the infection.
Established/labeled uses
- Bacterial vaginosis caused by anaerobic and mixed bacterial flora (e.g. Gardnerella vaginalis and other anaerobes).
- Trichomoniasis (vaginal infection caused by Trichomonas vaginalis), covered by the metronidazole component.
- Vulvovaginal candidiasis (yeast infection caused by Candida species), covered by the nystatin component.
- Vaginal infections with mixed gram-negative bacterial, anaerobic, protozoal, and fungal involvement, where broad local coverage in a single product is clinically useful.
Notes on evidence and use
Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B is intended for cases where a mixed or polymicrobial vaginal infection is suspected or confirmed by clinical examination and/or microscopy; it is not intended to replace pathogen-specific therapy when a single organism has been clearly identified and a narrower-spectrum agent is preferred by treatment guidelines. Use should be guided by a physician's assessment.
Dosage & Administration of Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B
Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B is for intravaginal use only and must be used exactly as prescribed by a physician.
| Indication | Typical adult dose | Typical duration |
|---|---|---|
| Mixed vaginal infection (bacterial vaginosis / trichomoniasis / candidiasis) | One vaginal tablet inserted deep into the vagina, usually at bedtime | 7 to 10 consecutive nights, or as directed by the prescribing physician |
Important: Take/use Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B exactly as prescribed by your physician; do not stop, extend, skip doses, or share this medicine with others without medical advice, even if symptoms improve before the course is finished. Stopping early can allow the infection to persist or recur.
Side Effects of Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B
Most side effects of Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B are local and mild, related to the site of application:
- Local vaginal or vulval irritation, itching, or burning sensation
- Increased or altered vaginal discharge
- Local redness or a mild allergic-type reaction at the application site
- Metallic taste in the mouth, occasionally reported due to limited systemic absorption of the metronidazole component
- Nausea or mild gastrointestinal upset (uncommon, related to systemic absorption)
- Rarely, systemic effects related to the aminoglycoside (neomycin) and polypeptide (polymyxin B) components, such as dizziness, have been reported, though vaginal use results in much lower systemic exposure than oral or injectable administration of these agents
Patients should stop use and consult a physician promptly if signs of a significant allergic reaction (rash, swelling, difficulty breathing) occur.
Contraindications of Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B
- Known hypersensitivity to metronidazole, neomycin sulphate, nystatin, polymyxin B, other nitroimidazole or aminoglycoside drugs, or any excipient in the formulation.
- First trimester of pregnancy, per standard conservative labeling for this combination product (see Pregnancy and Lactation).
Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B should not be used by patients with a known hypersensitivity as above. Other cautions (such as renal impairment) are relative precautions rather than absolute contraindications and are described under Precautions and Warnings.
Frequently Asked Questions about Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B
What is Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B used for?
Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B is a vaginal tablet used to treat mixed vaginal infections, where bacterial vaginosis, trichomoniasis, and/or a yeast (candida) infection may be present together. It provides broad local coverage against bacteria, protozoa, and fungi in one product.
How long should I use Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B for?
Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B is usually inserted into the vagina once daily, generally at bedtime, for about 7 to 10 consecutive nights, or for the exact duration your physician prescribes. It is important to complete the full course even if your symptoms improve earlier, to fully clear the infection and reduce the chance of it coming back.
Can I drink alcohol while using Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B?
No. Alcohol should be avoided during treatment with Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B and for at least 24 to 72 hours after finishing the course, because the metronidazole component can cause a disulfiram-like reaction with alcohol, leading to flushing, headache, nausea, vomiting, and palpitations.
Is Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B safe to use during pregnancy?
Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B is generally not recommended during the first trimester of pregnancy. In later pregnancy, it should only be used if your physician judges it clearly necessary and the benefits outweigh the potential risks. Always consult your physician before using Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B if you are pregnant or think you may be pregnant.
Can I have sex or use condoms while using Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B?
It is best to avoid intercourse during treatment with Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B. If you rely on latex condoms or diaphragms for contraception, be aware that the tablet's base may weaken latex, reducing its effectiveness; use an alternative method of contraception during treatment and for a short period afterward.
What should I do if I accidentally swallow a tablet of Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B or use too much?
If a tablet of Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B is accidentally swallowed, or if you think you have used more than prescribed, seek immediate medical attention or contact your local poison control center/emergency services rather than trying to manage it at home.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.