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Sodicarb600 mg
Popular Pharmaceuticals Ltd.
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Sodium Bicarbonate: Brands, Price & Uses in Bangladesh
Sodium Bicarbonate is indicated for the treatment and prevention of specific acid-base and electrolyte disturbances.
About Sodium Bicarbonate
Indications of Sodium Bicarbonate
Sodium Bicarbonate is indicated for the treatment and prevention of specific acid-base and electrolyte disturbances. Indications are classified below by strength of evidence.
Established/FDA-approved uses (parenteral)
- Treatment of metabolic acidosis associated with severe renal disease, uncontrolled diabetes mellitus (diabetic ketoacidosis, as adjunct therapy in severe cases with persistent acidosis despite fluid and insulin therapy), circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, and severe primary lactic acidosis.
- Adjunctive therapy in advanced cardiac life support for specific situations such as pre-existing metabolic acidosis, hyperkalemia, or tricyclic antidepressant overdose, per current resuscitation guidance (not for routine use in cardiac arrest).
- Severe salicylate or phenobarbital overdose, where urinary alkalinization increases renal elimination of the offending drug.
Established/OTC use (oral)
- Short-term, occasional relief of symptoms associated with hyperacidity, such as heartburn, acid indigestion, and upset stomach (antacid use).
- Urinary alkalinization for minor urinary discomfort or specific metabolic conditions, as directed by a physician.
Guideline-supported/adjunct use
- Management of chronic metabolic acidosis in chronic kidney disease, used under physician direction as an adjunct to overall management to help slow progression of renal disease.
Sodium Bicarbonate is not a first-line treatment for routine diabetic ketoacidosis or most cases of cardiac arrest and should be used only under direct medical supervision when indicated.
Dosage & Administration of Sodium Bicarbonate
Adult Dosing
| Indication | Typical Adult Dose of Sodium Bicarbonate |
|---|---|
| Severe metabolic acidosis (IV) | Individualized based on arterial blood gas/serum bicarbonate deficit: HCO3- deficit (mEq) = 0.5 x body weight (kg) x (desired HCO3- minus observed HCO3-); typically given as a slow IV infusion of Sodium Bicarbonate with repeat doses guided by serial blood gas monitoring. |
| Cardiac arrest (adjunct, selected situations) | Per current advanced cardiac life support protocols, generally 1 mEq/kg IV, only for specific indications (pre-existing metabolic acidosis, hyperkalemia, tricyclic antidepressant toxicity) and not for routine use. |
| Severe salicylate poisoning (urinary alkalinization) | IV infusion of Sodium Bicarbonate titrated to maintain urinary pH around 7.5-8, with close monitoring of serum electrolytes and pH. |
| Antacid (oral, OTC use) | 0.3-2 g of Sodium Bicarbonate in water, 1-4 times daily after meals and at bedtime; do not exceed the maximum labeled daily dose or use for more than 2 weeks without consulting a physician. |
Pediatric Dosing
In neonates and infants, IV Sodium Bicarbonate for severe metabolic acidosis is dosed on the calculated bicarbonate deficit and given as a slow infusion (not a rapid bolus), diluted as appropriate, due to the risk of hypernatremia and intracranial hemorrhage with rapid administration. Oral antacid use of Sodium Bicarbonate in children should only occur under physician direction.
Renal/Hepatic Adjustment
No specific hepatic dose adjustment for Sodium Bicarbonate is established. In renal impairment, Sodium Bicarbonate should be used cautiously with reduced doses and close monitoring, due to risk of sodium/fluid retention and delayed excretion of excess bicarbonate (see Use in Special Populations).
Side Effects of Sodium Bicarbonate
Adverse effects of Sodium Bicarbonate are generally related to sodium and alkali load and are more likely with excessive or prolonged use.
- Common: Belching, flatulence, and gastric distension with oral Sodium Bicarbonate, due to carbon dioxide release.
- Electrolyte/acid-base: Metabolic alkalosis, hypokalemia, hypernatremia, hypocalcemia (tetany in susceptible patients).
- Fluid-related: Fluid retention, edema, and, with high sodium load, worsening of hypertension or heart failure.
- Injection-site: Pain, irritation, and tissue necrosis if IV Sodium Bicarbonate extravasates.
- Other (rare): Hypersensitivity reactions.
Contraindications of Sodium Bicarbonate
Sodium Bicarbonate is contraindicated in patients with:
- Known hypersensitivity to Sodium Bicarbonate or any component of the formulation.
- Loss of chloride from vomiting or from continuous gastrointestinal suction.
- Concurrent use of diuretics known to produce hypochloremic alkalosis.
- Hypocalcemia, in which alkalosis induced by Sodium Bicarbonate may precipitate tetany.
- Metabolic or respiratory alkalosis.
Frequently Asked Questions about Sodium Bicarbonate
What is Sodium Bicarbonate used for?
Sodium Bicarbonate is used to correct metabolic acidosis (often given intravenously in a hospital setting), to alkalinize urine in certain poisoning cases, and, when taken orally, as a short-term antacid for heartburn, acid indigestion, and upset stomach.
Can I take Sodium Bicarbonate every day for indigestion?
No. Sodium Bicarbonate is intended for short-term or occasional antacid use only, generally not more than 2 weeks, unless a physician directs otherwise. Frequent or prolonged use of Sodium Bicarbonate can cause metabolic alkalosis, sodium overload, and fluid retention, and persistent indigestion should be evaluated by a doctor.
Who should not use Sodium Bicarbonate?
Sodium Bicarbonate should not be used by people who are losing chloride from vomiting or continuous stomach suction, those taking diuretics that cause hypochloremic alkalosis, patients with hypocalcemia (since alkalosis from Sodium Bicarbonate can trigger tetany), and patients who already have metabolic or respiratory alkalosis.
Is Sodium Bicarbonate safe during pregnancy and breastfeeding?
Sodium Bicarbonate should be used in pregnancy only if clearly needed, with a physician's guidance, as controlled studies are limited. During breastfeeding, occasional standard antacid doses of Sodium Bicarbonate are generally considered acceptable, but regular or high-dose use should be discussed with a doctor first.
What happens if I take too much Sodium Bicarbonate?
Taking too much Sodium Bicarbonate can cause metabolic alkalosis, low potassium, high sodium levels, muscle twitching, confusion, seizures, or abnormal heart rhythm. If an overdose of Sodium Bicarbonate is suspected, seek immediate medical attention or contact a poison control center.
Can Sodium Bicarbonate be given intravenously at home?
No. Intravenous Sodium Bicarbonate is administered only in a hospital or clinical setting by trained healthcare professionals, with careful monitoring of blood gases and electrolytes; it is not for home use.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.