Indications of Ariprazole 10 mg
Ariprazole 10 mg is indicated for-
Schizophrenia
Schizoaffective disorder
Acute manic and mixed episodes associated with Bipolar I Disorder
Maintaining efficacy in patients with Bipolar I Disorder who are stabilized
Theropeutic Class
Atypical neuroleptic drugs
Pharmacology
Ariprazole 10 mg is an atypical antipsychotic that has both dopamine and serotonin receptors activity. It is a partial agonist of dopamine D2 receptors that relieves the symptoms of schizophrenia. It is characterized as a dopamine system stabilizer. It is a potent partial agonist at serotonin 5-HT1A receptors and antagonist at 5-HT2A receptors. This is associated with improvement of depressive, cognitive and negative symptoms.
Dosage & Administration of Ariprazole 10 mg
For Schizophrenia: 10 to 15 mg, once daily, without regard to food. Dose increment should not be made before 2 weeks, the time needed to achieve steady state.For Bipolar mania: 30 mg, once daily, without regard to food.
Dosage of Ariprazole 10 mg
For Schizophrenia: 10 to 15 mg, once daily, without regard to food. Dose increment should not be made before 2 weeks, the time needed to achieve steady state.For Bipolar mania: 30 mg, once daily, without regard to food.
Interaction of Ariprazole 10 mg
Caution should be exercised when aripipazole is taken in combination with other centrally acting drugs and alcohol. Carbamazepine could cause an increase in Ariprazole 10 mg clearance and lower blood levels. Ketoconazole, quinidine, fluoxetine or paroxetine can inhibit Ariprazole 10 mg elimination and cause increased blood levels.
Contraindications
Ariprazole 10 mg is contraindicated in patients who are hypersensitive to it or to any component of this product.
Side Effects of Ariprazole 10 mg
Headache, constipation, asthenia, nausea, dyspepsia, vomiting, coughing, abdominal pain.
Pregnancy & Lactation
Ariprazole 10 mg should not be used in pregnancy as no human trial is performed. Patients should be advised not to breast feed an infant if they are taking Ariprazole 10 mg.
Precautions & Warnings
Ariprazole 10 mg may be associated with orthostatic hypotension (orthostatic lightheadedness).Ariprazole 10 mg should be used with caution in patients with known cardiovascular disease (myocardial infarction or ischaemic heart disease, heart failure or conduction abnormalities), cerebrovascular disease, or conditions that would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications).Seizures occurred in Ariprazole 10 mg-treated patients. As with other antipsychotic drugs, Ariprazole 10 mg should be used cautiously in patients with Alzheimer's dementia.Ariprazole 10 mg is not approved for the treatment of patients with dementia-related psychosis.
Overdose Effects of Ariprazole 10 mg
Ariprazole 10 mg at doses up to 1080 mg causes no fatalities. The signs and symptoms observed with Ariprazole 10 mg overdose included nausea, vomiting, asthenia, diarrhea, and somnolence.
Drug Classes
Atypical neuroleptic drugs
Mode Of Action
Ariprazole 10 mg is an atypical antipsychotic that has both dopamine and serotonin receptors activity. It is a partial agonist of dopamine D2 receptors that relieves the symptoms of schizophrenia. It is characterized as a dopamine system stabilizer. It is a potent partial agonist at serotonin 5-HT1A receptors and antagonist at 5-HT2A receptors. This is associated with improvement of depressive, cognitive and negative symptoms.
Pregnancy
Ariprazole 10 mg should not be used in pregnancy as no human trial is performed. Patients should be advised not to breast feed an infant if they are taking Ariprazole 10 mg.