Prevention and treatment of nauseavomitingdizzinessmotion sicknessradiation sickness and vertigo associated with diseases of the vestibular system (e.g. Meniere's syndromelabyrinthitis and other vestibular disturbances).

Theropeutic Class

Anti-emetic drugs

Pharmacology

Meclizine Hydrochloride prevents nausea and vomiting by reducing the activity of the center in the brain that controls nausea.

Absorption

It also prevents motion sickness by reducing excitability of neurons in the vestibular region of the brain.

Distribution

Pyridoxine Hydrochloride (vit.

Metabolism

B6), either alone or combination has been used to prevent nausea and vomiting due to its antiemetic properties.

Dosage & Administration of Emezin Plus 25 mg+50 mg

Nausea and vomiting during pregnancy

Dosage:1 tablet 1-2 times daily (after taking food) or as directed by the physician

Nausea and vomiting after surgery

Dosage:1-2 tablets daily

Nausea and vomiting induced by irradiation

Dosage:1 tablet (shortly before or after the irradiation)

Motion sickness

Dosage:1-2 tablets one hour prior to journey

Notes:This dose may be repeated every 24 hours, if required

Vertigo associated with vestibular system diseases

Dosage:1 tablet 2 times daily or as required

Condition	Dosage	Notes
Nausea and vomiting during pregnancy	1 tablet 1-2 times daily (after taking food) or as directed by the physician
Nausea and vomiting after surgery	1-2 tablets daily
Nausea and vomiting induced by irradiation	1 tablet (shortly before or after the irradiation)
Motion sickness	1-2 tablets one hour prior to journey	This dose may be repeated every 24 hours, if required
Vertigo associated with vestibular system diseases	1 tablet 2 times daily or as required

Dosage of Emezin Plus 25 mg+50 mg

Adult and Children 12 years of age & over

Dosage:Nausea and vomiting: 25-50 mg daily or as directed by a physician

Motion sickness

Dosage:Take an initial dose of 25-50 mg, 1 hour prior to travel

Notes:May repeat the dose every 24 hours for the duration of the journey

Radiation sickness

Dosage:50 mg administered 2-12 hours prior to radiation treatment

Vertigo

Dosage:25-100 mg daily in divided doses

Notes:Prevention of nausea and vomiting associated with emergency contraceptive pill (ECP): 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours. The safety and efficacy for use in children less than 12 years of age have not been established

Condition	Dosage	Notes
Adult and Children 12 years of age & over	Nausea and vomiting: 25-50 mg daily or as directed by a physician
Motion sickness	Take an initial dose of 25-50 mg, 1 hour prior to travel	May repeat the dose every 24 hours for the duration of the journey
Radiation sickness	50 mg administered 2-12 hours prior to radiation treatment
Vertigo	25-100 mg daily in divided doses	Prevention of nausea and vomiting associated with emergency contraceptive pill (ECP): 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours. The safety and efficacy for use in children less than 12 years of age have not been established

Interaction of Emezin Plus 25 mg+50 mg

The CNS depressant effects of Meclizine can be potentiated by concurrent use of Ethanol or other CNS depressant agents such as Benzodiazepines, Barbiturates, Tricyclic antidepressants, opiate agonists, skeletal muscle relaxants and antihistamines. Concurrent use of other anticholinergics can potentiate the anticholinergic effects of Meclizine. Meclizine can increase the absorption of digoxin by decreasing gastrointestinal motility.

Contraindications

Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.

Side Effects of Emezin Plus 25 mg+50 mg

Drowsiness, dry mouth and, on rare occasions, blurred vision have been reported.

Pregnancy & Lactation

There is no evidence of adverse effects of this combination on pregnancy or on the health of the fetus or neonate. But account should be taken with the use of antihistamines to just before the parturition. Pyridoxine is considered as safe in pregnancy. Pyridoxine is excreted in human milk but meclizine is unknown whether it is excreted or not. So, this combination may be indicated during lactation, if clearly needed.

Precautions & Warnings

Patients should be warned that Meclizine Hydrochloride may impair their ability to perform hazardous activities requiring mental alertness or physical coordination (e.g., operating machinery, driving a motor vehicle). Patients should avoid alcoholic beverages while taking this drug. Due to its potential anticholinergic action, this drug should be used with caution in patients with asthma, glaucoma or enlargement of the prostate gland.

Overdose Effects of Emezin Plus 25 mg+50 mg

Symptoms: Extreme excitability, seizures, drowsiness and hallucinations.Treatment: Appropriate supportive and symptomatic treatment. Consider dialysis

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Drug Classes

Anti-emetic drugs

Mode Of Action

Meclizine is a piperazine-derivative antihistamine that is used as an antiemetic. It has antiemetic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers. Pyridoxine is vitamin B-6. It has been added to enhance the anti-emetic effects & as a dietary suppliment.

Pregnancy

Pregnancy Category B. Large-scale human studies have not demonstrated adverse fetal effects. It has been suggested that based on available data, Meclizine presents the lowest risk of teratogenicity and is the drug of first choice in treating nausea and vomiting during pregnancy. Safety for use in the nursing mother has not been established.

Frequently Asked Questions

What is Emezin Plus 25 mg+50 mg used for?

Prevention and treatment of nausea, vomiting, dizziness, motion sickness, radiation sickness and vertigo associated with diseases of the vestibular system (e.g. Meniere's syndrome, labyrinthitis and other vestibular disturbances).

What is the dosage of Emezin Plus 25 mg+50 mg?

Adult and Children 12 years of age & over: Nausea and vomiting: 25-50 mg daily or as directed by a physician. Motion sickness: Take an initial dose of 25-50 mg, 1 hour prior to travel. May repeat the dose every 24 hours for the duration of the journey. Radiation sickness: 50 mg administered 2-12 hours prior to radiation treatment. Vertigo: 25-100 mg daily in divided doses. Prevention of nausea and…

What are the side effects of Emezin Plus 25 mg+50 mg?

Drowsiness, dry mouth and, on rare occasions, blurred vision have been reported.

Who should not take Emezin Plus 25 mg+50 mg?

Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.

What precautions should be taken with Emezin Plus 25 mg+50 mg?

Is Emezin Plus 25 mg+50 mg safe during pregnancy and breastfeeding?

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

Emezin Plus25 mg+50 mg

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Medicine overview

Indications of Emezin Plus 25 mg+50 mg