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Gabapen100 mg
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Medicine overview
Indications of Gabapen 100 mg
Gabapen 100 mg is indicated for-
Neuropathic Pain.
Adjunctive therapy in partial seizure and secondary generalized seizure.
Theropeutic Class
Adjunct anti-epileptic drugs
Pharmacology
Gabapen 100 mg is an anti-convulsant.
Absorption
It is a structural analog of gamma-amino-butyric-acid (GABA).
Distribution
All pharmacological actions following administration of Gabapen 100 mg are due to the activity of parent compound.
Metabolism
Gabapen 100 mg binds with the alpha-2-delta subunit of voltage gated L-type Calcium channel, and inhibits branched chain amino acid transferase & probably inhibits neurotransmitter release of excitatory amino acid.
Dosage of Gabapen 100 mg
Neuropathic Pain
Dosage:The treatment may be initiated as a single 300 mg dose on Day-1, than 300 mg twice on Day-2 and 300 mg thrice on Day-3
Notes:The dose can be subsequently be titrated up as needed for pain relief to a daily dose of 1800 mg (divided TID)
Epilepsy
Dosage:Patients over 12 years of age: the effective dose of Gabapen 100 mg is 900 to 1800 mg/day given in three divided doses
Notes:The starting dose is 300 mg three times a day
Paediatric patients age 3-12 year
Dosage:the starting dose should range from 10-15 mg/kg/day in 3 divided doses, and the effective dose reached by upward titration over a period of approximately three days
| Condition | Dosage | Notes |
|---|---|---|
| Neuropathic Pain | The treatment may be initiated as a single 300 mg dose on Day-1, than 300 mg twice on Day-2 and 300 mg thrice on Day-3 | The dose can be subsequently be titrated up as needed for pain relief to a daily dose of 1800 mg (divided TID) |
| Epilepsy | Patients over 12 years of age: the effective dose of Gabapen 100 mg is 900 to 1800 mg/day given in three divided doses | The starting dose is 300 mg three times a day |
| Paediatric patients age 3-12 year | the starting dose should range from 10-15 mg/kg/day in 3 divided doses, and the effective dose reached by upward titration over a period of approximately three days |
Administration of Gabapen 100 mg
Gabapen 100 mg can be taken orally with or without food.
Interaction of Gabapen 100 mg
Antacids may reduce the bioavailability of Gabapen 100 mg by up to 20 %. Cimetidine may alter its reanal excretion. Gabapen 100 mg does not interact with other anti-epileptic drug or with oral contraceptive preparations.
Contraindications
Gabapen 100 mg is contraindicated in patients who have known hypersensitivity to the drug.
Side Effects of Gabapen 100 mg
Fatigue, Dizziness, ataxia, weight gain, peripheral edema, dry mouth and somnolence may occur.
Pregnancy & Lactation
Pregnancy category C. it should be used during pregnancy only if potential benefits justifies the potential risk to the fetus. Gabapen 100 mg may be secreted through the breast milk. So it should be used during lactation only if potential benefits justifies the potential risk to the baby.
Precautions & Warnings
Patients should be instructed to take Gabapen 100 mg only as prescribed. While using Gabapen 100 mg patients should be instructed either not to drive a car or to operate other complex machinery until they have gained sufficient experiences about Gabapen 100 mg whether or not it affects their mental and/or motor performance adversely.
Storage Conditions
Store below 25°C temperature. Protect from light and moisture. Keep all the medicines out of the reach of the children.
Use In Special Populations
In case of renal impaired patients Gabapen 100 mg doses must be reduced.
Drug Classes
Adjunct anti-epileptic drugs
Mode Of Action
Gabapen 100 mg is an anti-convulsant. It is a structural analog of gamma-amino-butyric-acid (GABA). All pharmacological actions following administration of Gabapen 100 mg are due to the activity of parent compound. Gabapen 100 mg binds with the alpha-2-delta subunit of voltage gated L-type Calcium channel, and inhibits branched chain amino acid transferase & probably inhibits neurotransmitter release of excitatory amino acid.
Pregnancy
Pregnancy category C. it should be used during pregnancy only if potential benefits justifies the potential risk to the fetus. Gabapen 100 mg may be secreted through the breast milk. So it should be used during lactation only if potential benefits justifies the potential risk to the baby.
Pediatric Uses
In case of renal impaired patients Gabapen 100 mg doses must be reduced.
Frequently Asked Questions
What is Gabapen 100 mg used for?
Gabapentin is indicated for- Neuropathic Pain. Adjunctive therapy in partial seizure and secondary generalized seizure.
What is the dosage of Gabapen 100 mg?
Neuropathic Pain: The treatment may be initiated as a single 300 mg dose on Day-1, than 300 mg twice on Day-2 and 300 mg thrice on Day-3. The dose can be subsequently be titrated up as needed for pain relief to a daily dose of 1800 mg (divided TID).Epilepsy: Patients over 12 years of age: the effective dose of Gabapentin is 900 to 1800 mg/day given in three divided doses. The starting dose is 300 …
What are the side effects of Gabapen 100 mg?
Fatigue, Dizziness, ataxia, weight gain, peripheral edema, dry mouth and somnolence may occur.
Who should not take Gabapen 100 mg?
Gabapentin is contraindicated in patients who have known hypersensitivity to the drug.
What precautions should be taken with Gabapen 100 mg?
Patients should be instructed to take Gabapentin only as prescribed. While using Gabapentin patients should be instructed either not to drive a car or to operate other complex machinery until they have gained sufficient experiences about Gabapentin whether or not it affects their mental and/or motor performance adversely.
Is Gabapen 100 mg safe during pregnancy and breastfeeding?
Pregnancy category C. it should be used during pregnancy only if potential benefits justifies the potential risk to the fetus. Gabapentin may be secreted through the breast milk. So it should be used during lactation only if potential benefits justifies the potential risk to the baby.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.