Spirocard

Spirocard25 mg

Tablet

Spironolactone

Popular Pharmaceuticals Ltd.

Product Code : 16191
MRP 5.50
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Medicine overview

Indications of Spirocard 25 mg

Spirocard 25 mg is indicated in Congestive heart failure, Hepatic cirrhosis with ascites and oedema, Nephrotic syndrome, Primary hyperaldosteronism, Essential hypertension, For the treatment of patients with hypokalemia

Theropeutic Class

Potassium-sparing diuretics, Potassium-sparing diuretics & Aldosterone antagonists

Pharmacology

Spirocard 25 mg is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Spirocard 25 mg causes increased amounts of sodium and water to be excreted, while potassium is retained. Spirocard 25 mg acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule. Aldosterone interacts with a cytoplasmic mineralocorticoid receptor to enhance the expression of the Na+ K+ ATPase and the Na+ channel involved in a Na+ K+ transport in the distal tubule . Spirocard 25 mg bind to this mineralcorticoid receptor, blocking the actions of aldosterone on gene expression. Aldosterone is a hormone; its primary function is to retain sodium and excrete potassium in the kidneys.

Dosage & Administration of Spirocard 25 mg

Edema in adults (congestive heart failure, hepatic cirrhosis, or nephrotic syndrome): An initial daily dosage of 100 mg of Spirocard 25 mg administered in either single or divided doses is recommended, but may range from 25 to 200 mg daily. Combined therapy with other diuretics is indicated when more rapid diuresis is desired.Primary hyperaldosteronism: After the diagnosis of hyperaldosteronism has been established, Spirocard 25 mg may be administered in doses of 100 to 400 mg daily in preparation for surgery. For patients who are considered unsuitable for surgery, Spirocard 25 mg may be employed for long-term maintenance therapy at the lowest effective dosage determined for the individual patient.Essential hypertension: For adults, an initial daily dosage of 50 to 100 mg of Spirocard 25 mg administered in either single or divided doses is recommended.Hypokalemia: Spirocard 25 mg in a dosage ranging from 25 mg to 100 mg daily is useful in treating a diuretic-induced hypokalemia.

Dosage of Spirocard 25 mg

Edema in adults (congestive heart failure, hepatic cirrhosis, or nephrotic syndrome): An initial daily dosage of 100 mg of Spirocard 25 mg administered in either single or divided doses is recommended, but may range from 25 to 200 mg daily. Combined therapy with other diuretics is indicated when more rapid diuresis is desired.Primary hyperaldosteronism: After the diagnosis of hyperaldosteronism has been established, Spirocard 25 mg may be administered in doses of 100 to 400 mg daily in preparation for surgery. For patients who are considered unsuitable for surgery, Spirocard 25 mg may be employed for long-term maintenance therapy at the lowest effective dosage determined for the individual patient.Essential hypertension: For adults, an initial daily dosage of 50 to 100 mg of Spirocard 25 mg administered in either single or divided doses is recommended.Hypokalemia: Spirocard 25 mg in a dosage ranging from 25 mg to 100 mg daily is useful in treating a diuretic-induced hypokalemia.

Interaction of Spirocard 25 mg

ACE inhibitors: Concomitant administration of ACE inhibitors with potassium-sparing diuretics has been associated with severe hyperkalemia.Alcohol, barbiturates, or narcotics: Potentiation of orthostatic hypotension may occur.Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia, may occur. Lithium: Lithium generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.Digoxin: Spirocard 25 mg has been shown to increase the half-life of digoxin.

Contraindications

Spirocard 25 mg is contraindicated in patients with acute renal insufficiency, significant impairment of renal function, anuria, hyperkalaemia or sensitivity to Spirocard 25 mg.

Side Effects of Spirocard 25 mg

Gynaecomastia may develop in association with the use of Spirocard 25 mg. Other adverse reactions are: GI symptoms including cramping and diarrhoea, drowsiness, lethargy, headache, urticaria, mental confusion, impotence, irregular menses or amenorrhoea and post-menopausal bleeding.

Pregnancy & Lactation

Pregnancy: Spirocard 25 mg should not be used during pregnancyLactation: Canrenone, an active metabolite of Spirocard 25 mg, appears in breast milk. If use of the drug is deemed essential an alternative method of infant feeding should be instituted.

Precautions & Warnings

All patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance. Hyperkalemia may occur in patients with impaired renal function or excessive potassium intake and can cause cardiac irregularities, which may be fatal.

Overdose Effects of Spirocard 25 mg

Symptoms of overdosage include drowsiness, mental confusion, dizziness, diarrhea and vomiting etc. Patients should induce vomiting or evacuate the stomach by lavage during Spirocard 25 mg overdoasge.

Storage Conditions

Store in a cool and dry place protected from light. Keep out of reach of children.

Drug Classes

Potassium-sparing diuretics, Potassium-sparing diuretics & Aldosterone antagonists

Mode Of Action

Spirocard 25 mg is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Spirocard 25 mg causes increased amounts of sodium and water to be excreted, while potassium is retained. Spirocard 25 mg acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule. Aldosterone interacts with a cytoplasmic mineralocorticoid receptor to enhance the expression of the Na+ K+ ATPase and the Na+ channel involved in a Na+ K+ transport in the distal tubule . Spirocard 25 mg bind to this mineralcorticoid receptor, blocking the actions of aldosterone on gene expression. Aldosterone is a hormone; its primary function is to retain sodium and excrete potassium in the kidneys.

Pregnancy

Pregnancy: Spirocard 25 mg should not be used during pregnancyLactation: Canrenone, an active metabolite of Spirocard 25 mg, appears in breast milk. If use of the drug is deemed essential an alternative method of infant feeding should be instituted.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.