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Travagen Z0.004%
Ophthalmic Solution
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Medicine overview
Indications of Travagen Z 0.004%
Travagen Z 0.004% Eye Drops is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are intolerant of or insufficiently responsive to another intraocular pressure lowering medication, as monotherapy or as adjunctive therapy.
Theropeutic Class
Drugs for miotics and glaucoma
Pharmacology
Travagen Z 0.004%, an isopropyl ester prodrug, is a synthetic prostaglandin F2 alpha analogue that is rapidly hydrolyzed by esterases in the cornea to its biologically active free acid.
Absorption
The travoporst free acid is potent and highly selective for the FP prostanoid receptor.
Distribution
Travagen Z 0.004% free acid is a selective FP prostanoid receptor agonist and is believed to reduce intraocular pressure by increasing the drainage of aqueous humor, which is done primarily through increased uveoscleral outflow and to a lesser extent, trabecular outflow facility.
Dosage & Administration of Travagen Z 0.004%
Use in adults
Dosage:The recommended dose is one drops of Travagen Z 0.004% in the conjunctival sac of the affected eye (s) once daily in the evening, If more than one topical ophthalmic product is being used, the medicines must be administered at least 5 minutes apart
Notes:When substituting another ophthalmic antiglaucoma agent with Travagen Z 0.004%, discontinue the other agent and start the following day with Travagen Z 0.004%
Pediatric patients
Dosage:The efficacy and safety of Travagen Z 0.004% eye drops in patients below the age of 18 years have not been established
| Condition | Dosage | Notes |
|---|---|---|
| Use in adults | The recommended dose is one drops of Travagen Z 0.004% in the conjunctival sac of the affected eye (s) once daily in the evening, If more than one topical ophthalmic product is being used, the medicines must be administered at least 5 minutes apart | When substituting another ophthalmic antiglaucoma agent with Travagen Z 0.004%, discontinue the other agent and start the following day with Travagen Z 0.004% |
| Pediatric patients | The efficacy and safety of Travagen Z 0.004% eye drops in patients below the age of 18 years have not been established |
Dosage of Travagen Z 0.004%
Use in adults
Dosage:The recommended dose is one drops of Travagen Z 0.004% in the conjunctival sac of the affected eye (s) once daily in the evening, If more than one topical ophthalmic product is being used, the medicines must be administered at least 5 minutes apart
Notes:When substituting another ophthalmic antiglaucoma agent with Travagen Z 0.004%, discontinue the other agent and start the following day with Travagen Z 0.004%
Pediatric patients
Dosage:The efficacy and safety of Travagen Z 0.004% eye drops in patients below the age of 18 years have not been established
| Condition | Dosage | Notes |
|---|---|---|
| Use in adults | The recommended dose is one drops of Travagen Z 0.004% in the conjunctival sac of the affected eye (s) once daily in the evening, If more than one topical ophthalmic product is being used, the medicines must be administered at least 5 minutes apart | When substituting another ophthalmic antiglaucoma agent with Travagen Z 0.004%, discontinue the other agent and start the following day with Travagen Z 0.004% |
| Pediatric patients | The efficacy and safety of Travagen Z 0.004% eye drops in patients below the age of 18 years have not been established |
Interaction of Travagen Z 0.004%
Reduced therapeutic effect with NSAIDs.
Contraindications
Travagen Z 0.004% eye drops is contraindicated in patients with hypersensitive to Travagen Z 0.004% or any excipients of this preparation.
Side Effects of Travagen Z 0.004%
The most frequently reported treatment-related side-effect is ocular hyperaemia.
Pregnancy & Lactation
There are no adequate and well-controlled clinical study En pregnant women. Travagen Z 0.004% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.It is not known whether the drug or its metabolites are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Travagen Z 0.004% is administered to a lactating woman.
Precautions & Warnings
Travagen Z 0.004% should be used with caution in patients with active intraocular inflammation (iritis/uveitis). Travagen Z 0.004% should not be administered while wearing contact lenses. Contact lenses should be removed prior to the administration of the solution. Lenses may be reinserted 15 minutes following administration of Travagen Z 0.004%.
Storage Conditions
Store in a cool, dry place and protected from light. Keep out of reach of children. Discard the container 4 weeks after opening.
Drug Classes
Drugs for miotics and glaucoma
Mode Of Action
Travagen Z 0.004%, an isopropyl ester prodrug, is a synthetic prostaglandin F2 alpha analogue that is rapidly hydrolyzed by esterases in the cornea to its biologically active free acid. The travoporst free acid is potent and highly selective for the FP prostanoid receptor.Travagen Z 0.004% free acid is a selective FP prostanoid receptor agonist and is believed to reduce intraocular pressure by increasing the drainage of aqueous humor, which is done primarily through increased uveoscleral outflow and to a lesser extent, trabecular outflow facility.
Pregnancy
There are no adequate and well-controlled clinical study En pregnant women. Travagen Z 0.004% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.It is not known whether the drug or its metabolites are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Travagen Z 0.004% is administered to a lactating woman.
Frequently Asked Questions
What is Travagen Z 0.004% used for?
Travoprost Eye Drops is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are intolerant of or insufficiently responsive to another intraocular pressure lowering medication, as monotherapy or as adjunctive therapy.
What is the dosage of Travagen Z 0.004%?
Use in adults: The recommended dose is one drops of Travoprost in the conjunctival sac of the affected eye (s) once daily in the evening, If more than one topical ophthalmic product is being used, the medicines must be administered at least 5 minutes apart. When substituting another ophthalmic antiglaucoma agent with Travoprost, discontinue the other agent and start the following day with Travopro…
What are the side effects of Travagen Z 0.004%?
The most frequently reported treatment-related side-effect is ocular hyperaemia.
Who should not take Travagen Z 0.004%?
Travoprost eye drops is contraindicated in patients with hypersensitive to travoprost or any excipients of this preparation.
What precautions should be taken with Travagen Z 0.004%?
Travoprost should be used with caution in patients with active intraocular inflammation (iritis/uveitis). Travoprost should not be administered while wearing contact lenses. Contact lenses should be removed prior to the administration of the solution. Lenses may be reinserted 15 minutes following administration of Travoprost.
Is Travagen Z 0.004% safe during pregnancy and breastfeeding?
There are no adequate and well-controlled clinical study En pregnant women. Travoprost should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.It is not known whether the drug or its metabolites are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when travoprost is administered to a lactating woman.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.