Bilicir

Bilicir300 mg

Tablet

Ursodeoxycholic Acid

ACI Limited

Product Code : 2249
MRP 20.00
10% Off
Best PriceTk
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Section

Medicine overview

Indications of Bilicir 300 mg

Bilicir 300 mg is indicated for the treatment of Cholestasis (Jaundice), Viral Hepatitis, Alcoholic Fatty Liver, Primary Billiary Cirrhosis (PBC), Primary Sclerosing Cholangitis (PSC), Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis (NASH).

Theropeutic Class

Anti-gallstones drugs: Bile Acids

Pharmacology

Bilicir 300 mg is a naturally occurring bile acid used to treat different hepatobilliary disorders. The activity of Bilicir 300 mg is achieved through a decrease in secretion of cholesterol in bile. Bilicir 300 mg achieves this through a few mechanisms: it reduces cholesterol absorption, suppresses liver cholesterol synthesis and it does not inhibit bile acid synthesis.Therefore, alters bile composition from supersaturated to unsaturated. Bilicir 300 mg also promotes the formation of liquid cholesterol crystal complexes which enhance removal of the cholesterol from the gallbladder into the intestine to be expelled. Bilicir 300 mg improves cholestatic liver diseases by- Protecting cholangiocytes against cytotoxicity of hydrophobic bile acids Stimulating hepatobilliary secretion Protecting hepatocytes against bile acid-induced apoptosis Bilicir 300 mg is completely absorbed in the upper intestine. Time to peak serum concentration varies from 30 to 150 minutes. The rate of absorption ranges from 60-80%. After absorption Bilicir 300 mg enters the portal vein and undergoes extraction from portal blood by liver where it is conjugated with amino acid & that may be either glycine or taurine and then secreted into the hepatic bile ducts. Small quantities of Bilicir 300 mg appear in the circulation and very small amounts are excreted into urine. The biologic half life of Bilicir 300 mg ranges from 3.5-5.8 days.

Dosage & Administration of Bilicir 300 mg

Dissolution of Gall stones: 8-12 mg/kg/day either as single night time dose or in divided dosesPBC: 10-15 mg/kg/day in 2-4 divided dosesAcute Viral Hepatitis: 600 mg/dayAlcoholic Fatty Liver: 300 mg/dayPSC: 25-30 mg/kg/dayNASH: 13-15 mg/kg/day

Interaction of Bilicir 300 mg

Bilicir 300 mg should not be used with drugs, such as oestrogenic hormones, that increase bile cholesterol. Concomitant administration with bile-acid binding drugs including antacids, charcoal and cholestyramine should be avoided, since this may reduce the effectiveness of therapy with Ursodeoxycholic acid.

Contraindications

Non-functioning gall-bladder calcified and pigmented gallstones, inflammatory bowel disease.

Side Effects of Bilicir 300 mg

Commonly reported side effects are nausea, vomiting, diarrhoea, gallstone opacilication, pruritus.

Pregnancy & Lactation

Pregnancy category B. No evidence of harm has been reported in pregnancy. It has been effectively used for the treatment of cholestasis of pregnancy during the last trimester without any side effects. Problems have not been documented in humans regarding breast feeding.

Precautions & Warnings

It should be used cautiously in those with liver disease.

Storage Conditions

Store below 25° C. Protected from light and moisture. Keep the medicine out of the reach of children.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.